Stable HEV IgG seroprevalence in Belgium between 2006 and 2014
Recent European studies suggest an emergence of hepatitis E virus (HEV) infection. We evaluated trends in birth cohort‐specific HEV seroprevalence and regional differences in Belgium. HEV IgG seroprevalence was analysed on national serum banks (1579 and 2087 samples for 2006 and 2014, respectively....
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| Veröffentlicht in: | Journal of viral hepatitis 2020-11, Vol.27 (11), p.1253-1260 |
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| container_title | Journal of viral hepatitis |
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| creator | Ho, Erwin Schenk, Julie Hutse, Veronik Suin, Vanessa Litzroth, Amber Blaizot, Stéphanie Herzog, Sereina A. Verburgh, Vera Jacques, Marjorie Rahman, Abbas Michielsen, Peter Van Damme, Pierre Van Gucht, Steven Theeten, Heidi Hens, Niel Vanwolleghem, Thomas |
| description | Recent European studies suggest an emergence of hepatitis E virus (HEV) infection. We evaluated trends in birth cohort‐specific HEV seroprevalence and regional differences in Belgium. HEV IgG seroprevalence was analysed on national serum banks (1579 and 2087 samples for 2006 and 2014, respectively. Hepatitis E virus antigen was tested on positive samples. Observed data were modelled using a generalized additive model with a complementary log‐log link. No significant differences between birth cohorts or sexes were found. Modelling identified the individual's age and province as relevant factors. The probability of HEV seropositivity increases significantly with age. An estimated total of 434 819 (yearly rate of 54,352) (sero‐)infections were found between 2006 and 2014. Overall, HEV IgG seroprevalences were 4.1% (64/1579, 95% CI 3.1‐5.1) and 5.8% (121/2087, CI 4.8‐6.9) in 2006 and 2014, respectively. Observed HEV antigen seroprevalence was 0.027% (1/3666) for the entire cohort. These results show stable HEV IgG seroprevalence in Belgium. |
| doi_str_mv | 10.1111/jvh.13347 |
| format | Article |
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We evaluated trends in birth cohort‐specific HEV seroprevalence and regional differences in Belgium. HEV IgG seroprevalence was analysed on national serum banks (1579 and 2087 samples for 2006 and 2014, respectively. Hepatitis E virus antigen was tested on positive samples. Observed data were modelled using a generalized additive model with a complementary log‐log link. No significant differences between birth cohorts or sexes were found. Modelling identified the individual's age and province as relevant factors. The probability of HEV seropositivity increases significantly with age. An estimated total of 434 819 (yearly rate of 54,352) (sero‐)infections were found between 2006 and 2014. Overall, HEV IgG seroprevalences were 4.1% (64/1579, 95% CI 3.1‐5.1) and 5.8% (121/2087, CI 4.8‐6.9) in 2006 and 2014, respectively. Observed HEV antigen seroprevalence was 0.027% (1/3666) for the entire cohort. These results show stable HEV IgG seroprevalence in Belgium.</description><identifier>ISSN: 1352-0504</identifier><identifier>EISSN: 1365-2893</identifier><identifier>DOI: 10.1111/jvh.13347</identifier><identifier>PMID: 32564516</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Antigens ; Belgium ; epidemiology ; Europe ; Hepatitis ; hepatitis E ; Immunoglobulin G ; Serology</subject><ispartof>Journal of viral hepatitis, 2020-11, Vol.27 (11), p.1253-1260</ispartof><rights>2020 John Wiley & Sons Ltd</rights><rights>2020 John Wiley & Sons Ltd.</rights><rights>Copyright © 2020 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4587-7475f15e9ed2664cb606f4e3eaa8c944c8c6fee753e451b92364d90a96120ce83</citedby><cites>FETCH-LOGICAL-c4587-7475f15e9ed2664cb606f4e3eaa8c944c8c6fee753e451b92364d90a96120ce83</cites><orcidid>0000-0002-0572-8741 ; 0000-0001-7232-8927 ; 0000-0001-5642-5006 ; 0000-0002-5373-5866</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjvh.13347$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjvh.13347$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32564516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ho, Erwin</creatorcontrib><creatorcontrib>Schenk, Julie</creatorcontrib><creatorcontrib>Hutse, Veronik</creatorcontrib><creatorcontrib>Suin, Vanessa</creatorcontrib><creatorcontrib>Litzroth, Amber</creatorcontrib><creatorcontrib>Blaizot, Stéphanie</creatorcontrib><creatorcontrib>Herzog, Sereina A.</creatorcontrib><creatorcontrib>Verburgh, Vera</creatorcontrib><creatorcontrib>Jacques, Marjorie</creatorcontrib><creatorcontrib>Rahman, Abbas</creatorcontrib><creatorcontrib>Michielsen, Peter</creatorcontrib><creatorcontrib>Van Damme, Pierre</creatorcontrib><creatorcontrib>Van Gucht, Steven</creatorcontrib><creatorcontrib>Theeten, Heidi</creatorcontrib><creatorcontrib>Hens, Niel</creatorcontrib><creatorcontrib>Vanwolleghem, Thomas</creatorcontrib><title>Stable HEV IgG seroprevalence in Belgium between 2006 and 2014</title><title>Journal of viral hepatitis</title><addtitle>J Viral Hepat</addtitle><description>Recent European studies suggest an emergence of hepatitis E virus (HEV) infection. We evaluated trends in birth cohort‐specific HEV seroprevalence and regional differences in Belgium. HEV IgG seroprevalence was analysed on national serum banks (1579 and 2087 samples for 2006 and 2014, respectively. Hepatitis E virus antigen was tested on positive samples. Observed data were modelled using a generalized additive model with a complementary log‐log link. No significant differences between birth cohorts or sexes were found. Modelling identified the individual's age and province as relevant factors. The probability of HEV seropositivity increases significantly with age. An estimated total of 434 819 (yearly rate of 54,352) (sero‐)infections were found between 2006 and 2014. Overall, HEV IgG seroprevalences were 4.1% (64/1579, 95% CI 3.1‐5.1) and 5.8% (121/2087, CI 4.8‐6.9) in 2006 and 2014, respectively. Observed HEV antigen seroprevalence was 0.027% (1/3666) for the entire cohort. These results show stable HEV IgG seroprevalence in Belgium.</description><subject>Antigens</subject><subject>Belgium</subject><subject>epidemiology</subject><subject>Europe</subject><subject>Hepatitis</subject><subject>hepatitis E</subject><subject>Immunoglobulin G</subject><subject>Serology</subject><issn>1352-0504</issn><issn>1365-2893</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp10E1PwkAQBuCN0QiiB_-AaeJFD8X9bnsxUYKAIfGgct1st1MsKS3uUgj_3sWiBxPnMnN48mbyInRJcJ_4uVtsPvqEMR4doS5hUoQ0Ttjx_hY0xALzDjpzboExYVSQU9TxS3JBZBfdv651WkIwHs6CyXwUOLD1ysJGl1AZCIoqeIRyXjTLIIX1FqAKKMYy0FXmD8LP0UmuSwcXh91D70_Dt8E4nL6MJoOHaWi4iKMw4pHIiYAEMiolN6nEMufAQOvYJJyb2MgcIBIM_FtpQpnkWYJ1IgnFBmLWQzdt7srWnw24tVoWzkBZ6grqxinKiYhpHAni6fUfuqgbW_nvvOJxRCVJhFe3rTK2ds5Crla2WGq7UwSrfanKl6q-S_X26pDYpEvIfuVPix7ctWBblLD7P0k9z8Zt5BfMEXwF</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Ho, Erwin</creator><creator>Schenk, Julie</creator><creator>Hutse, Veronik</creator><creator>Suin, Vanessa</creator><creator>Litzroth, Amber</creator><creator>Blaizot, Stéphanie</creator><creator>Herzog, Sereina A.</creator><creator>Verburgh, Vera</creator><creator>Jacques, Marjorie</creator><creator>Rahman, Abbas</creator><creator>Michielsen, Peter</creator><creator>Van Damme, Pierre</creator><creator>Van Gucht, Steven</creator><creator>Theeten, Heidi</creator><creator>Hens, Niel</creator><creator>Vanwolleghem, Thomas</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0572-8741</orcidid><orcidid>https://orcid.org/0000-0001-7232-8927</orcidid><orcidid>https://orcid.org/0000-0001-5642-5006</orcidid><orcidid>https://orcid.org/0000-0002-5373-5866</orcidid></search><sort><creationdate>202011</creationdate><title>Stable HEV IgG seroprevalence in Belgium between 2006 and 2014</title><author>Ho, Erwin ; Schenk, Julie ; Hutse, Veronik ; Suin, Vanessa ; Litzroth, Amber ; Blaizot, Stéphanie ; Herzog, Sereina A. ; Verburgh, Vera ; Jacques, Marjorie ; Rahman, Abbas ; Michielsen, Peter ; Van Damme, Pierre ; Van Gucht, Steven ; Theeten, Heidi ; Hens, Niel ; Vanwolleghem, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4587-7475f15e9ed2664cb606f4e3eaa8c944c8c6fee753e451b92364d90a96120ce83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antigens</topic><topic>Belgium</topic><topic>epidemiology</topic><topic>Europe</topic><topic>Hepatitis</topic><topic>hepatitis E</topic><topic>Immunoglobulin G</topic><topic>Serology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ho, Erwin</creatorcontrib><creatorcontrib>Schenk, Julie</creatorcontrib><creatorcontrib>Hutse, Veronik</creatorcontrib><creatorcontrib>Suin, Vanessa</creatorcontrib><creatorcontrib>Litzroth, Amber</creatorcontrib><creatorcontrib>Blaizot, Stéphanie</creatorcontrib><creatorcontrib>Herzog, Sereina A.</creatorcontrib><creatorcontrib>Verburgh, Vera</creatorcontrib><creatorcontrib>Jacques, Marjorie</creatorcontrib><creatorcontrib>Rahman, Abbas</creatorcontrib><creatorcontrib>Michielsen, Peter</creatorcontrib><creatorcontrib>Van Damme, Pierre</creatorcontrib><creatorcontrib>Van Gucht, Steven</creatorcontrib><creatorcontrib>Theeten, Heidi</creatorcontrib><creatorcontrib>Hens, Niel</creatorcontrib><creatorcontrib>Vanwolleghem, Thomas</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of viral hepatitis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ho, Erwin</au><au>Schenk, Julie</au><au>Hutse, Veronik</au><au>Suin, Vanessa</au><au>Litzroth, Amber</au><au>Blaizot, Stéphanie</au><au>Herzog, Sereina A.</au><au>Verburgh, Vera</au><au>Jacques, Marjorie</au><au>Rahman, Abbas</au><au>Michielsen, Peter</au><au>Van Damme, Pierre</au><au>Van Gucht, Steven</au><au>Theeten, Heidi</au><au>Hens, Niel</au><au>Vanwolleghem, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stable HEV IgG seroprevalence in Belgium between 2006 and 2014</atitle><jtitle>Journal of viral hepatitis</jtitle><addtitle>J Viral Hepat</addtitle><date>2020-11</date><risdate>2020</risdate><volume>27</volume><issue>11</issue><spage>1253</spage><epage>1260</epage><pages>1253-1260</pages><issn>1352-0504</issn><eissn>1365-2893</eissn><abstract>Recent European studies suggest an emergence of hepatitis E virus (HEV) infection. We evaluated trends in birth cohort‐specific HEV seroprevalence and regional differences in Belgium. HEV IgG seroprevalence was analysed on national serum banks (1579 and 2087 samples for 2006 and 2014, respectively. Hepatitis E virus antigen was tested on positive samples. Observed data were modelled using a generalized additive model with a complementary log‐log link. No significant differences between birth cohorts or sexes were found. Modelling identified the individual's age and province as relevant factors. The probability of HEV seropositivity increases significantly with age. An estimated total of 434 819 (yearly rate of 54,352) (sero‐)infections were found between 2006 and 2014. Overall, HEV IgG seroprevalences were 4.1% (64/1579, 95% CI 3.1‐5.1) and 5.8% (121/2087, CI 4.8‐6.9) in 2006 and 2014, respectively. Observed HEV antigen seroprevalence was 0.027% (1/3666) for the entire cohort. 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| subjects | Antigens Belgium epidemiology Europe Hepatitis hepatitis E Immunoglobulin G Serology |
| title | Stable HEV IgG seroprevalence in Belgium between 2006 and 2014 |
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