The Clinical impact of PTPN11 mutations in adults with acute myeloid leukemia

While germline and somatic mutations in the gene PTPN11 , encoding a phosphatase which regulates the RAS signaling pathway, are well characterized in children with Noonan syndrome and juvenile myelomonocytic leukemia, less is known about their clinical impact in adults with acute myeloid leukemia (A...

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Veröffentlicht in:	Leukemia 2021-03, Vol.35 (3), p.691-700
Hauptverfasser:	Alfayez, Mansour, Issa, Ghayas C., Patel, Keyur P., Wang, Feng, Wang, Xuemei, Short, Nicholas J., Cortes, Jorge E., Kadia, Tapan, Ravandi, Farhad, Pierce, Sherry, Assi, Rita, Garcia-Manero, Guillermo, DiNardo, Courtney D., Daver, Naval, Pemmaraju, Naveen, Kantarjian, Hagop, Borthakur, Gautam
Format:	Artikel
Sprache:	eng
Schlagworte:	45/23 631/67/1990/283/1897 631/67/69 692/699/67/1990/283/1897 Acute myeloid leukemia Adolescent Adult Adults Aged Aged, 80 and over Biomarkers, Tumor - genetics Cancer Research Cohort Studies Critical Care Medicine Esterases Female Follow-Up Studies Gene mutations Health aspects Hematology Humans Intensive Internal Medicine Juveniles Karyotypes Leukemia Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - mortality Leukemia, Myeloid, Acute - pathology Male Medical prognosis Medicine Medicine & Public Health Middle Aged Monocytes Monocytic leukemia Multivariate analysis Mutation Myeloid leukemia Myelomonocytic leukemia Next-generation sequencing Noonan's syndrome Nucleophosmin Oncology Phenotypes Prognosis Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics Signal transduction Survival Rate Young Adult
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