Engraftment kinetics after transplantation of double unit cord blood grafts combined with haplo-identical CD34+ cells without antithymocyte globulin

Double unit cord blood (dCB) transplantation (dCBT) is associated with high engraftment rates but delayed myeloid recovery. We investigated adding haplo-identical CD34+ cells to dCB grafts to facilitate early haplo-identical donor-derived neutrophil recovery (optimal bridging) prior to CB engraftmen...

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Veröffentlicht in:	Leukemia 2021-03, Vol.35 (3), p.850-862
Hauptverfasser:	Politikos, Ioannis, Devlin, Sean M., Arcila, Maria E., Barone, Jonathan C., Maloy, Molly A., Naputo, Kristine A., Ruiz, Josel D., Mazis, Christopher M., Scaradavou, Andromachi, Avecilla, Scott T., Dahi, Parastoo B., Giralt, Sergio A., Hsu, Katherine C., Jakubowski, Ann A., Papadopoulos, Esperanza B., Perales, Miguel A., Sauter, Craig S., Tamari, Roni, Ponce, Doris M., O’Reilly, Richard J., Barker, Juliet N.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1854/2812 631/250/1904 692/700/565/2319 Adult Aged Antigens Antigens, CD34 - metabolism Antilymphocyte Serum Blood Cancer Cancer Research Care and treatment CD34 antigen Clinical Trials, Phase II as Topic Cord blood Critical Care Medicine Cyclosporins Donor Selection Engraftment Female Fetal blood Fetal Blood - transplantation Follow-Up Studies Globulins Graft rejection Graft vs Host Disease - prevention & control Grafting Grafts Haplotypes Hematologic Neoplasms - pathology Hematologic Neoplasms - therapy Hematology Hematopoietic Stem Cell Transplantation - methods Histocompatibility antigen HLA HLA Antigens - immunology Humans Immune response Immunoprophylaxis Intensive Internal Medicine Leukocytes Leukocytes (neutrophilic) Lymphocytes Lymphocytes T Male Medicine Medicine & Public Health Middle Aged Mycophenolate mofetil Mycophenolic acid Neutrophils Observations Oncology Oncology, Experimental Optimization Prognosis Recovery Thymocytes Transplantation Transplantation Conditioning Young Adult
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