Idebenone Protects against Atherosclerosis in Apolipoprotein E-Deficient Mice Via Activation of the SIRT3-SOD2-mtROS Pathway

Purpose Atherosclerosis, a chronic disease of the arteries, results from pathological processes including the accumulation and aggregation of oxidized low-density lipoprotein (oxLDL) in the vessel walls, development of neointima, formation of a fibrous cap, and migration of immune cells to damaged v...

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Veröffentlicht in:	Cardiovascular drugs and therapy 2021-12, Vol.35 (6), p.1129-1145
Hauptverfasser:	Jiang, Wei, Geng, Hongzhi, Lv, Xiaoqing, Ma, Jing, Liu, Fuchen, Lin, Pengfei, Yan, Chuanzhu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Apolipoprotein E Apolipoproteins Apolipoproteins E Apoptosis - drug effects Arteries Arteriosclerosis Atherosclerosis Atherosclerosis - physiopathology Benzoquinone Cardiology Cell migration Cell Survival - drug effects Cholesterol Chronic illnesses Coenzyme Q10 Damage Endothelial cells Endothelium Free radicals High fat diet Human performance Human Umbilical Vein Endothelial Cells Humans Immune system Male Medicine Medicine & Public Health Mice Mice, Transgenic Mitochondria Mitochondria - drug effects Original Article Oxidative stress Oxidative Stress - drug effects Plaques Proteomics Random Allocation Reactive oxygen species Reactive Oxygen Species - metabolism Sirtuin 3 - drug effects Staining Superoxide dismutase Superoxide Dismutase - drug effects Ubiquinone - analogs & derivatives Ubiquinone - pharmacology Umbilical vein Voltage-Sensitive Dye Imaging
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