Initial surgical resection and long time to occurrence from initial diagnosis are independent prognostic factors in resected recurrent IDH wild-type glioblastoma
•Aim of the study: analyzed the clinical benefits of second surgery at recurrence and the prognostic factors of IDH wild-type glioblastoma patients.•We enrolled 229 new IDH wild-type glioblastoma patients who met the inclusion criteria; 25% of patients were reoperated.•Reoperated patients had longer...
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| Veröffentlicht in: | Clinical neurology and neurosurgery 2020-09, Vol.196, p.106006-106006, Article 106006 |
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| creator | Seyve, Antoine Lozano-Sanchez, Fernando Thomas, Alice Mathon, Bertrand Tran, Suzanne Mokhtari, Karima Giry, Marine Marie, Yannick Capelle, Laurent Peyre, Matthieu Carpentier, Alexandre Feuvret, Loic Sanson, Marc Hoang-Xuan, Khê Honnorat, Jérome Delattre, Jean-Yves Ducray, François Idbaih, Ahmed |
| description | •Aim of the study: analyzed the clinical benefits of second surgery at recurrence and the prognostic factors of IDH wild-type glioblastoma patients.•We enrolled 229 new IDH wild-type glioblastoma patients who met the inclusion criteria; 25% of patients were reoperated.•Reoperated patients had longer post-progression median overall survival compared to their non-reoperated counterparts (14 vs 9 months, p < .05).•Initial surgical resection and a long time to the first recurrence after the initial diagnosis were independent prognostic factors of a good outcome.•Prospective studies are warranted in a more extensive format to validate our findings.
IDH wild-type glioblastoma is the most common and aggressive primary brain cancer in adults. At tumor recurrence, treatment decision-making is not standardized; several options include second surgery, reirradiation, and a second line of chemotherapy. In this retrospective monocentric study conducted at the era of WHO 2016 classification, we investigated IDH wild-type glioblastoma patients below the age of 70 to see (i) the clinical benefit of second surgery at recurrence and (ii) the prognostic factors in resected recurrent glioblastoma patients.
229 newly diagnosed IDH wild-type glioblastoma patients below the age of 70 treated with the standard of care (SOC) were enrolled in the current study and stratified into two subgroups according to treatment at recurrence: re-resection and no re-resection.
All experienced tumor recurrence with a median progression-free survival of 11 months. 25 % of patients were reoperated. Patients reoperated at recurrence had longer post-progression median overall survival compared to their non-reoperated counterparts (14 versus 9 months, p < .05). Initial surgical resection and a long time from the initial diagnosis to the first recurrence were independent prognostic factors for good outcomes in resected recurrent IDH-wild-type glioblastoma patients; however, tumor size before and after surgery did not impact post-surgical survival.
Our study supports surgical resection at recurrence as therapeutic in IDH wild-type glioblastoma patients aged below 70 and in good clinical condition regardless of preoperative tumor size, particularly in patients who experienced a longer time before first recurrence and surgery at initial diagnosis. Further prospective and larger studies are warranted to validate our findings. |
| doi_str_mv | 10.1016/j.clineuro.2020.106006 |
| format | Article |
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IDH wild-type glioblastoma is the most common and aggressive primary brain cancer in adults. At tumor recurrence, treatment decision-making is not standardized; several options include second surgery, reirradiation, and a second line of chemotherapy. In this retrospective monocentric study conducted at the era of WHO 2016 classification, we investigated IDH wild-type glioblastoma patients below the age of 70 to see (i) the clinical benefit of second surgery at recurrence and (ii) the prognostic factors in resected recurrent glioblastoma patients.
229 newly diagnosed IDH wild-type glioblastoma patients below the age of 70 treated with the standard of care (SOC) were enrolled in the current study and stratified into two subgroups according to treatment at recurrence: re-resection and no re-resection.
All experienced tumor recurrence with a median progression-free survival of 11 months. 25 % of patients were reoperated. Patients reoperated at recurrence had longer post-progression median overall survival compared to their non-reoperated counterparts (14 versus 9 months, p < .05). Initial surgical resection and a long time from the initial diagnosis to the first recurrence were independent prognostic factors for good outcomes in resected recurrent IDH-wild-type glioblastoma patients; however, tumor size before and after surgery did not impact post-surgical survival.
Our study supports surgical resection at recurrence as therapeutic in IDH wild-type glioblastoma patients aged below 70 and in good clinical condition regardless of preoperative tumor size, particularly in patients who experienced a longer time before first recurrence and surgery at initial diagnosis. Further prospective and larger studies are warranted to validate our findings.</description><identifier>ISSN: 0303-8467</identifier><identifier>EISSN: 1872-6968</identifier><identifier>DOI: 10.1016/j.clineuro.2020.106006</identifier><identifier>PMID: 32554237</identifier><language>eng</language><publisher>AMSTERDAM: Elsevier B.V</publisher><subject>Age ; Biopsy ; Brain cancer ; Cancer ; Chemotherapy ; Clinical Neurology ; Decision making ; Diagnosis ; Gender ; Glioblastoma ; Human health and pathology ; IDH wild-type ; Life Sciences ; Life Sciences & Biomedicine ; Medical prognosis ; Multivariate analysis ; Neurobiology ; Neurology ; Neurons and Cognition ; Neuropathology ; Neurosciences & Neurology ; Overall survival ; Patients ; Progression-free survival ; Recurrent glioblastoma ; Reoperation ; Science & Technology ; Surgery ; Survival ; Tumors</subject><ispartof>Clinical neurology and neurosurgery, 2020-09, Vol.196, p.106006-106006, Article 106006</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><rights>2020. Elsevier B.V.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>9</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000571448600014</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c548t-7ec50d3561f7b5825390abee0827d86c69f9fb78e78342f47b1db4c08be83c8a3</citedby><cites>FETCH-LOGICAL-c548t-7ec50d3561f7b5825390abee0827d86c69f9fb78e78342f47b1db4c08be83c8a3</cites><orcidid>0000-0002-8533-3976 ; 0000-0002-9182-5846 ; 0000-0001-8470-9516 ; 0000-0002-8150-5785 ; 0000-0002-1813-8476 ; 0000-0002-4013-2660 ; 0000-0002-4721-5952 ; 0000-0001-5290-1204</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2441553395?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,315,782,786,887,3552,27931,27932,28255,46002,64392,64394,64396,72476</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32554237$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.sorbonne-universite.fr/hal-02962217$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Seyve, Antoine</creatorcontrib><creatorcontrib>Lozano-Sanchez, Fernando</creatorcontrib><creatorcontrib>Thomas, Alice</creatorcontrib><creatorcontrib>Mathon, Bertrand</creatorcontrib><creatorcontrib>Tran, Suzanne</creatorcontrib><creatorcontrib>Mokhtari, Karima</creatorcontrib><creatorcontrib>Giry, Marine</creatorcontrib><creatorcontrib>Marie, Yannick</creatorcontrib><creatorcontrib>Capelle, Laurent</creatorcontrib><creatorcontrib>Peyre, Matthieu</creatorcontrib><creatorcontrib>Carpentier, Alexandre</creatorcontrib><creatorcontrib>Feuvret, Loic</creatorcontrib><creatorcontrib>Sanson, Marc</creatorcontrib><creatorcontrib>Hoang-Xuan, Khê</creatorcontrib><creatorcontrib>Honnorat, Jérome</creatorcontrib><creatorcontrib>Delattre, Jean-Yves</creatorcontrib><creatorcontrib>Ducray, François</creatorcontrib><creatorcontrib>Idbaih, Ahmed</creatorcontrib><title>Initial surgical resection and long time to occurrence from initial diagnosis are independent prognostic factors in resected recurrent IDH wild-type glioblastoma</title><title>Clinical neurology and neurosurgery</title><addtitle>CLIN NEUROL NEUROSUR</addtitle><addtitle>Clin Neurol Neurosurg</addtitle><description>•Aim of the study: analyzed the clinical benefits of second surgery at recurrence and the prognostic factors of IDH wild-type glioblastoma patients.•We enrolled 229 new IDH wild-type glioblastoma patients who met the inclusion criteria; 25% of patients were reoperated.•Reoperated patients had longer post-progression median overall survival compared to their non-reoperated counterparts (14 vs 9 months, p < .05).•Initial surgical resection and a long time to the first recurrence after the initial diagnosis were independent prognostic factors of a good outcome.•Prospective studies are warranted in a more extensive format to validate our findings.
IDH wild-type glioblastoma is the most common and aggressive primary brain cancer in adults. At tumor recurrence, treatment decision-making is not standardized; several options include second surgery, reirradiation, and a second line of chemotherapy. In this retrospective monocentric study conducted at the era of WHO 2016 classification, we investigated IDH wild-type glioblastoma patients below the age of 70 to see (i) the clinical benefit of second surgery at recurrence and (ii) the prognostic factors in resected recurrent glioblastoma patients.
229 newly diagnosed IDH wild-type glioblastoma patients below the age of 70 treated with the standard of care (SOC) were enrolled in the current study and stratified into two subgroups according to treatment at recurrence: re-resection and no re-resection.
All experienced tumor recurrence with a median progression-free survival of 11 months. 25 % of patients were reoperated. Patients reoperated at recurrence had longer post-progression median overall survival compared to their non-reoperated counterparts (14 versus 9 months, p < .05). Initial surgical resection and a long time from the initial diagnosis to the first recurrence were independent prognostic factors for good outcomes in resected recurrent IDH-wild-type glioblastoma patients; however, tumor size before and after surgery did not impact post-surgical survival.
Our study supports surgical resection at recurrence as therapeutic in IDH wild-type glioblastoma patients aged below 70 and in good clinical condition regardless of preoperative tumor size, particularly in patients who experienced a longer time before first recurrence and surgery at initial diagnosis. Further prospective and larger studies are warranted to validate our findings.</description><subject>Age</subject><subject>Biopsy</subject><subject>Brain cancer</subject><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Clinical Neurology</subject><subject>Decision making</subject><subject>Diagnosis</subject><subject>Gender</subject><subject>Glioblastoma</subject><subject>Human health and pathology</subject><subject>IDH wild-type</subject><subject>Life Sciences</subject><subject>Life Sciences & Biomedicine</subject><subject>Medical prognosis</subject><subject>Multivariate analysis</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neurons and Cognition</subject><subject>Neuropathology</subject><subject>Neurosciences & Neurology</subject><subject>Overall survival</subject><subject>Patients</subject><subject>Progression-free survival</subject><subject>Recurrent glioblastoma</subject><subject>Reoperation</subject><subject>Science & 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surgical resection and long time to occurrence from initial diagnosis are independent prognostic factors in resected recurrent IDH wild-type glioblastoma</title><author>Seyve, Antoine ; Lozano-Sanchez, Fernando ; Thomas, Alice ; Mathon, Bertrand ; Tran, Suzanne ; Mokhtari, Karima ; Giry, Marine ; Marie, Yannick ; Capelle, Laurent ; Peyre, Matthieu ; Carpentier, Alexandre ; Feuvret, Loic ; Sanson, Marc ; Hoang-Xuan, Khê ; Honnorat, Jérome ; Delattre, Jean-Yves ; Ducray, François ; Idbaih, Ahmed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c548t-7ec50d3561f7b5825390abee0827d86c69f9fb78e78342f47b1db4c08be83c8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Biopsy</topic><topic>Brain cancer</topic><topic>Cancer</topic><topic>Chemotherapy</topic><topic>Clinical Neurology</topic><topic>Decision making</topic><topic>Diagnosis</topic><topic>Gender</topic><topic>Glioblastoma</topic><topic>Human health and pathology</topic><topic>IDH wild-type</topic><topic>Life Sciences</topic><topic>Life Sciences & Biomedicine</topic><topic>Medical prognosis</topic><topic>Multivariate analysis</topic><topic>Neurobiology</topic><topic>Neurology</topic><topic>Neurons and Cognition</topic><topic>Neuropathology</topic><topic>Neurosciences & Neurology</topic><topic>Overall survival</topic><topic>Patients</topic><topic>Progression-free survival</topic><topic>Recurrent glioblastoma</topic><topic>Reoperation</topic><topic>Science & Technology</topic><topic>Surgery</topic><topic>Survival</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seyve, Antoine</creatorcontrib><creatorcontrib>Lozano-Sanchez, Fernando</creatorcontrib><creatorcontrib>Thomas, Alice</creatorcontrib><creatorcontrib>Mathon, Bertrand</creatorcontrib><creatorcontrib>Tran, 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seyve, Antoine</au><au>Lozano-Sanchez, Fernando</au><au>Thomas, Alice</au><au>Mathon, Bertrand</au><au>Tran, Suzanne</au><au>Mokhtari, Karima</au><au>Giry, Marine</au><au>Marie, Yannick</au><au>Capelle, Laurent</au><au>Peyre, Matthieu</au><au>Carpentier, Alexandre</au><au>Feuvret, Loic</au><au>Sanson, Marc</au><au>Hoang-Xuan, Khê</au><au>Honnorat, Jérome</au><au>Delattre, Jean-Yves</au><au>Ducray, François</au><au>Idbaih, Ahmed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Initial surgical resection and long time to occurrence from initial diagnosis are independent prognostic factors in resected recurrent IDH wild-type glioblastoma</atitle><jtitle>Clinical neurology and neurosurgery</jtitle><stitle>CLIN NEUROL NEUROSUR</stitle><addtitle>Clin Neurol Neurosurg</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>196</volume><spage>106006</spage><epage>106006</epage><pages>106006-106006</pages><artnum>106006</artnum><issn>0303-8467</issn><eissn>1872-6968</eissn><abstract>•Aim of the study: analyzed the clinical benefits of second surgery at recurrence and the prognostic factors of IDH wild-type glioblastoma patients.•We enrolled 229 new IDH wild-type glioblastoma patients who met the inclusion criteria; 25% of patients were reoperated.•Reoperated patients had longer post-progression median overall survival compared to their non-reoperated counterparts (14 vs 9 months, p < .05).•Initial surgical resection and a long time to the first recurrence after the initial diagnosis were independent prognostic factors of a good outcome.•Prospective studies are warranted in a more extensive format to validate our findings.
IDH wild-type glioblastoma is the most common and aggressive primary brain cancer in adults. At tumor recurrence, treatment decision-making is not standardized; several options include second surgery, reirradiation, and a second line of chemotherapy. In this retrospective monocentric study conducted at the era of WHO 2016 classification, we investigated IDH wild-type glioblastoma patients below the age of 70 to see (i) the clinical benefit of second surgery at recurrence and (ii) the prognostic factors in resected recurrent glioblastoma patients.
229 newly diagnosed IDH wild-type glioblastoma patients below the age of 70 treated with the standard of care (SOC) were enrolled in the current study and stratified into two subgroups according to treatment at recurrence: re-resection and no re-resection.
All experienced tumor recurrence with a median progression-free survival of 11 months. 25 % of patients were reoperated. Patients reoperated at recurrence had longer post-progression median overall survival compared to their non-reoperated counterparts (14 versus 9 months, p < .05). Initial surgical resection and a long time from the initial diagnosis to the first recurrence were independent prognostic factors for good outcomes in resected recurrent IDH-wild-type glioblastoma patients; however, tumor size before and after surgery did not impact post-surgical survival.
Our study supports surgical resection at recurrence as therapeutic in IDH wild-type glioblastoma patients aged below 70 and in good clinical condition regardless of preoperative tumor size, particularly in patients who experienced a longer time before first recurrence and surgery at initial diagnosis. Further prospective and larger studies are warranted to validate our findings.</abstract><cop>AMSTERDAM</cop><pub>Elsevier B.V</pub><pmid>32554237</pmid><doi>10.1016/j.clineuro.2020.106006</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-8533-3976</orcidid><orcidid>https://orcid.org/0000-0002-9182-5846</orcidid><orcidid>https://orcid.org/0000-0001-8470-9516</orcidid><orcidid>https://orcid.org/0000-0002-8150-5785</orcidid><orcidid>https://orcid.org/0000-0002-1813-8476</orcidid><orcidid>https://orcid.org/0000-0002-4013-2660</orcidid><orcidid>https://orcid.org/0000-0002-4721-5952</orcidid><orcidid>https://orcid.org/0000-0001-5290-1204</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0303-8467 |
| ispartof | Clinical neurology and neurosurgery, 2020-09, Vol.196, p.106006-106006, Article 106006 |
| issn | 0303-8467 1872-6968 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2415297438 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; ProQuest Central UK/Ireland |
| subjects | Age Biopsy Brain cancer Cancer Chemotherapy Clinical Neurology Decision making Diagnosis Gender Glioblastoma Human health and pathology IDH wild-type Life Sciences Life Sciences & Biomedicine Medical prognosis Multivariate analysis Neurobiology Neurology Neurons and Cognition Neuropathology Neurosciences & Neurology Overall survival Patients Progression-free survival Recurrent glioblastoma Reoperation Science & Technology Surgery Survival Tumors |
| title | Initial surgical resection and long time to occurrence from initial diagnosis are independent prognostic factors in resected recurrent IDH wild-type glioblastoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-05T05%3A39%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_webof&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Initial%20surgical%20resection%20and%20long%20time%20to%20occurrence%20from%20initial%20diagnosis%20are%20independent%20prognostic%20factors%20in%20resected%20recurrent%20IDH%20wild-type%20glioblastoma&rft.jtitle=Clinical%20neurology%20and%20neurosurgery&rft.au=Seyve,%20Antoine&rft.date=2020-09-01&rft.volume=196&rft.spage=106006&rft.epage=106006&rft.pages=106006-106006&rft.artnum=106006&rft.issn=0303-8467&rft.eissn=1872-6968&rft_id=info:doi/10.1016/j.clineuro.2020.106006&rft_dat=%3Cproquest_webof%3E2415297438%3C/proquest_webof%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2441553395&rft_id=info:pmid/32554237&rft_els_id=S0303846720303498&rfr_iscdi=true |