Micro‐needling versus fractional carbon dioxide laser for delivery of tranexamic acid in the treatment of melasma: A split‐face study
Background Tranexamic acid (TXA) in oral, topical, and intra‐dermal injection routes showed efficacy in melasma treatment. Micro‐needling and fractional carbon dioxide (CO2) laser were reported to enhance the drug delivery of TXA. Aims This study aimed at comparing the use of micro‐needling and frac...
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| Veröffentlicht in: | Journal of cosmetic dermatology 2021-02, Vol.20 (2), p.460-465 |
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| container_title | Journal of cosmetic dermatology |
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| creator | Mekawy, Khaled M. M. Sadek, Ahmed Seddeik Abdel‐Hameed, Ahmad K. |
| description | Background
Tranexamic acid (TXA) in oral, topical, and intra‐dermal injection routes showed efficacy in melasma treatment. Micro‐needling and fractional carbon dioxide (CO2) laser were reported to enhance the drug delivery of TXA.
Aims
This study aimed at comparing the use of micro‐needling and fractional CO2 laser for drug delivery of TXA in the treatment of facial melasma.
Patients/Methods
Thirty female patients with bilateral symmetrical facial melasma were subjected to micro‐needling, for one side of the face, and fractional CO2 laser, for the other, followed by an immediate topical application of TXA solution 4 mg/mL. Patients received six biweekly sessions.
Results
Two weeks after the last session, a significant reduction in baseline modified melasma area and severity index (mMASI) score was observed on both sides. The mean ± SD baseline mMASI dropped from 3.43 ± 1.84 to 1.59 ± 1.51 (mean reduction 57.73%, P |
| doi_str_mv | 10.1111/jocd.13537 |
| format | Article |
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Tranexamic acid (TXA) in oral, topical, and intra‐dermal injection routes showed efficacy in melasma treatment. Micro‐needling and fractional carbon dioxide (CO2) laser were reported to enhance the drug delivery of TXA.
Aims
This study aimed at comparing the use of micro‐needling and fractional CO2 laser for drug delivery of TXA in the treatment of facial melasma.
Patients/Methods
Thirty female patients with bilateral symmetrical facial melasma were subjected to micro‐needling, for one side of the face, and fractional CO2 laser, for the other, followed by an immediate topical application of TXA solution 4 mg/mL. Patients received six biweekly sessions.
Results
Two weeks after the last session, a significant reduction in baseline modified melasma area and severity index (mMASI) score was observed on both sides. The mean ± SD baseline mMASI dropped from 3.43 ± 1.84 to 1.59 ± 1.51 (mean reduction 57.73%, P < .001) and from 3.51 ± 1.84 to 1.78 ± 1.51 (mean reduction 55.82%, P < .001) in the micro‐needling–treated side and in the fractional CO2 laser–treated side, respectively. However, no statistically significant differences were found between the two sides (P = .81).
Conclusions
Micro‐needling and fractional CO2 laser are equally safe and effective for the delivery of TXA in the treatment of facial melasma.</description><identifier>ISSN: 1473-2130</identifier><identifier>EISSN: 1473-2165</identifier><identifier>DOI: 10.1111/jocd.13537</identifier><identifier>PMID: 32562337</identifier><language>eng</language><publisher>England</publisher><subject>Combined Modality Therapy ; Female ; fractional CO2 laser ; Humans ; Lasers, Gas - adverse effects ; Low-Level Light Therapy ; Melanosis - drug therapy ; melasma ; micro‐needling ; Tranexamic Acid</subject><ispartof>Journal of cosmetic dermatology, 2021-02, Vol.20 (2), p.460-465</ispartof><rights>2020 Wiley Periodicals, LLC</rights><rights>2020 Wiley Periodicals, LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3997-d32732458be904dbce455d0a3d2b57732ad47281158968247c998dd34dfe61c63</citedby><cites>FETCH-LOGICAL-c3997-d32732458be904dbce455d0a3d2b57732ad47281158968247c998dd34dfe61c63</cites><orcidid>0000-0002-5138-9883</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjocd.13537$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjocd.13537$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32562337$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mekawy, Khaled M. M.</creatorcontrib><creatorcontrib>Sadek, Ahmed</creatorcontrib><creatorcontrib>Seddeik Abdel‐Hameed, Ahmad K.</creatorcontrib><title>Micro‐needling versus fractional carbon dioxide laser for delivery of tranexamic acid in the treatment of melasma: A split‐face study</title><title>Journal of cosmetic dermatology</title><addtitle>J Cosmet Dermatol</addtitle><description>Background
Tranexamic acid (TXA) in oral, topical, and intra‐dermal injection routes showed efficacy in melasma treatment. Micro‐needling and fractional carbon dioxide (CO2) laser were reported to enhance the drug delivery of TXA.
Aims
This study aimed at comparing the use of micro‐needling and fractional CO2 laser for drug delivery of TXA in the treatment of facial melasma.
Patients/Methods
Thirty female patients with bilateral symmetrical facial melasma were subjected to micro‐needling, for one side of the face, and fractional CO2 laser, for the other, followed by an immediate topical application of TXA solution 4 mg/mL. Patients received six biweekly sessions.
Results
Two weeks after the last session, a significant reduction in baseline modified melasma area and severity index (mMASI) score was observed on both sides. The mean ± SD baseline mMASI dropped from 3.43 ± 1.84 to 1.59 ± 1.51 (mean reduction 57.73%, P < .001) and from 3.51 ± 1.84 to 1.78 ± 1.51 (mean reduction 55.82%, P < .001) in the micro‐needling–treated side and in the fractional CO2 laser–treated side, respectively. However, no statistically significant differences were found between the two sides (P = .81).
Conclusions
Micro‐needling and fractional CO2 laser are equally safe and effective for the delivery of TXA in the treatment of facial melasma.</description><subject>Combined Modality Therapy</subject><subject>Female</subject><subject>fractional CO2 laser</subject><subject>Humans</subject><subject>Lasers, Gas - adverse effects</subject><subject>Low-Level Light Therapy</subject><subject>Melanosis - drug therapy</subject><subject>melasma</subject><subject>micro‐needling</subject><subject>Tranexamic Acid</subject><issn>1473-2130</issn><issn>1473-2165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOxCAUhonReN_4AIalMRktUEpxZ8Z7NG503VA4VQwtI7Q6s3Przmf0SWQcdenZcHLOxw_5ENoh2QFJdfjktTkgjDOxhNZJLtiIkoIv__UsW0MbMT5lGRGS8FW0xigvKGNiHb3fWB3859tHB2Cc7R7wC4Q4RNwEpXvrO-WwVqH2HTbWT60B7FSEgBsfsAFnEz7DvsF9UB1MVWs1VtoabDvcP0Iag-pb6Po500K626ojfIzjxNk-PdsoDTj2g5ltoZVGuQjbP-cmuj87vRtfjK5vzy_Hx9cjzaQUI8OoYDTnZQ0yy02tIefcZIoZWnORVsrkgpaE8FIWJc2FlrI0huWmgYLogm2ivUXuJPjnAWJftTZqcC793w-xojnhVIqMyYTuL9CkKMYATTUJtlVhVpGsmquv5uqrb_UJ3v3JHeoWzB_66zoBZAG8Wgezf6Kqq9vxySL0C6Z1kcE</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Mekawy, Khaled M. M.</creator><creator>Sadek, Ahmed</creator><creator>Seddeik Abdel‐Hameed, Ahmad K.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5138-9883</orcidid></search><sort><creationdate>202102</creationdate><title>Micro‐needling versus fractional carbon dioxide laser for delivery of tranexamic acid in the treatment of melasma: A split‐face study</title><author>Mekawy, Khaled M. M. ; Sadek, Ahmed ; Seddeik Abdel‐Hameed, Ahmad K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3997-d32732458be904dbce455d0a3d2b57732ad47281158968247c998dd34dfe61c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Combined Modality Therapy</topic><topic>Female</topic><topic>fractional CO2 laser</topic><topic>Humans</topic><topic>Lasers, Gas - adverse effects</topic><topic>Low-Level Light Therapy</topic><topic>Melanosis - drug therapy</topic><topic>melasma</topic><topic>micro‐needling</topic><topic>Tranexamic Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mekawy, Khaled M. M.</creatorcontrib><creatorcontrib>Sadek, Ahmed</creatorcontrib><creatorcontrib>Seddeik Abdel‐Hameed, Ahmad K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cosmetic dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mekawy, Khaled M. M.</au><au>Sadek, Ahmed</au><au>Seddeik Abdel‐Hameed, Ahmad K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Micro‐needling versus fractional carbon dioxide laser for delivery of tranexamic acid in the treatment of melasma: A split‐face study</atitle><jtitle>Journal of cosmetic dermatology</jtitle><addtitle>J Cosmet Dermatol</addtitle><date>2021-02</date><risdate>2021</risdate><volume>20</volume><issue>2</issue><spage>460</spage><epage>465</epage><pages>460-465</pages><issn>1473-2130</issn><eissn>1473-2165</eissn><abstract>Background
Tranexamic acid (TXA) in oral, topical, and intra‐dermal injection routes showed efficacy in melasma treatment. Micro‐needling and fractional carbon dioxide (CO2) laser were reported to enhance the drug delivery of TXA.
Aims
This study aimed at comparing the use of micro‐needling and fractional CO2 laser for drug delivery of TXA in the treatment of facial melasma.
Patients/Methods
Thirty female patients with bilateral symmetrical facial melasma were subjected to micro‐needling, for one side of the face, and fractional CO2 laser, for the other, followed by an immediate topical application of TXA solution 4 mg/mL. Patients received six biweekly sessions.
Results
Two weeks after the last session, a significant reduction in baseline modified melasma area and severity index (mMASI) score was observed on both sides. The mean ± SD baseline mMASI dropped from 3.43 ± 1.84 to 1.59 ± 1.51 (mean reduction 57.73%, P < .001) and from 3.51 ± 1.84 to 1.78 ± 1.51 (mean reduction 55.82%, P < .001) in the micro‐needling–treated side and in the fractional CO2 laser–treated side, respectively. However, no statistically significant differences were found between the two sides (P = .81).
Conclusions
Micro‐needling and fractional CO2 laser are equally safe and effective for the delivery of TXA in the treatment of facial melasma.</abstract><cop>England</cop><pmid>32562337</pmid><doi>10.1111/jocd.13537</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5138-9883</orcidid></addata></record> |
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| ispartof | Journal of cosmetic dermatology, 2021-02, Vol.20 (2), p.460-465 |
| issn | 1473-2130 1473-2165 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Combined Modality Therapy Female fractional CO2 laser Humans Lasers, Gas - adverse effects Low-Level Light Therapy Melanosis - drug therapy melasma micro‐needling Tranexamic Acid |
| title | Micro‐needling versus fractional carbon dioxide laser for delivery of tranexamic acid in the treatment of melasma: A split‐face study |
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