Role of JAK-STAT signaling in the pathogenic behavior of fibroblast-like synoviocytes in rheumatoid arthritis: Effect of the novel JAK inhibitor peficitinib

Rheumatoid arthritis (RA) fibroblast-like synoviocytes (RA-FLS) play a crucial role in the pathogenesis of RA. RA-FLS display passive pro-inflammatory responses and self-directed aggressive responses, such as pro-inflammatory mediator production, reduced apoptosis and formation of a thickened synovi...

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Veröffentlicht in:	European journal of pharmacology 2020-09, Vol.882, p.173238-173238, Article 173238
Hauptverfasser:	Emori, Takashi, Kasahara, Michiko, Sugahara, Shingo, Hashimoto, Motomu, Ito, Hiromu, Narumiya, Shuh, Higashi, Yasuyuki, Fujii, Yasutomo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adamantane - analogs & derivatives Adamantane - pharmacology Apoptosis - drug effects Arthritis, Rheumatoid - metabolism Azetidines - pharmacology Cells, Cultured Cytokines - metabolism Fibroblast-like synoviocytes Humans Janus kinase Janus Kinase Inhibitors - pharmacology Janus Kinases - antagonists & inhibitors Janus Kinases - metabolism Niacinamide - analogs & derivatives Niacinamide - pharmacology Peficitinib Phosphorylation - drug effects Piperidines - pharmacology Purines - pharmacology Pyrazoles - pharmacology Pyrimidines - pharmacology Rheumatoid arthritis Signal transducer and activator of transcription Signal Transduction - drug effects STAT3 Transcription Factor - metabolism Sulfonamides - pharmacology Synoviocytes - drug effects Synoviocytes - metabolism
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