Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity

Transcription factors (TFs) that bind common DNA motifs in vitro occupy distinct sets of promoters in vivo, raising the question of how binding specificity is achieved. TFs are enriched with intrinsically disordered regions (IDRs). Such regions commonly form promiscuous interactions, yet their uniqu...

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Veröffentlicht in:	Molecular cell 2020-08, Vol.79 (3), p.459-471.e4
Hauptverfasser:	Brodsky, Sagie, Jana, Tamar, Mittelman, Karin, Chapal, Michal, Kumar, Divya Krishna, Carmi, Miri, Barkai, Naama
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA binding intrinsically disordered proteins intrinsically disordered regions transcription factors
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