In utero exposure to phenanthrene induces hepatic steatosis in F1 adult female mice

Environmental pollutants are thought to be a risk factor for the prevalence of hepatic steatosis. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous, and human exposure is inevitable. In the present study, phenanthrene (Phe) was used as a representative PAH to investigate the effects of in utero...

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Veröffentlicht in:	Chemosphere (Oxford) 2020-11, Vol.258, p.127360, Article 127360
Hauptverfasser:	Guo, Jiaojiao, Zhang, Shenli, Fang, Lu, Huang, Jie, Wang, Qian, Wang, Chonggang, Chen, Meng
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged, 80 and over Animals Environmental Pollutants - toxicity Epigenesis, Genetic - drug effects Fatty Liver - embryology Fatty Liver - metabolism Fatty Liver - virology Female Hepatic steatosis Humans In utero exposure Lipid Metabolism - drug effects Lipid Metabolism - genetics Lipogenesis - drug effects Lipogenesis - genetics Lipolysis - drug effects Lipolysis - genetics Liver - drug effects Liver - growth & development Liver - metabolism Mice Mice, Inbred C57BL Phenanthrene Phenanthrenes - toxicity Polycyclic aromatic hydrocarbon (PAH) Pregnancy Prenatal Exposure Delayed Effects - virology Promoter methylation Transcription, Genetic - genetics
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