The risk of pregnancy‐associated hypertension in women with nonalcoholic fatty liver disease
Background & Aims Nonalcoholic fatty liver disease (NAFLD) is an independent predictor of cardiovascular disease (CVD) in non‐pregnant adults. Although the biological mechanisms underlying this association are not completely understood, metabolic factors, inflammation, and endothelial dysfunctio...
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| Veröffentlicht in: | Liver international 2020-10, Vol.40 (10), p.2417-2426 |
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| creator | Jung, Young Mi Lee, Seung Mi Hong, Subeen Koo, Ja Nam Oh, Ig Hwan Kim, Byoung Jae Kim, Sun Min Kim, Sang Youn Kim, Gyoung Min Kyung Joo, Sae Shin, Sue Norwitz, Errol R. Park, Chan‐Wook Jun, Jong Kwan Kim, Won Park, Joong Shin |
| description | Background & Aims
Nonalcoholic fatty liver disease (NAFLD) is an independent predictor of cardiovascular disease (CVD) in non‐pregnant adults. Although the biological mechanisms underlying this association are not completely understood, metabolic factors, inflammation, and endothelial dysfunction are likely all involved. The association between NAFLD and pregnancy‐associated hypertension (HTN) has not been systematically examined. The aim of this study is to assess the risk of pregnancy‐associated HTN in pregnant women with NAFLD.
Methods
This is secondary analysis of a prospective study of healthy pregnant women. Liver ultrasonography was performed at 10‐14 weeks of gestation and maternal blood was taken for the measurement of selenoprotein P (SeP), a hepatokine independently associated with both NAFLD and CVD. Pregnancy‐associated HTN was defined as the development of gestational HTN, preeclampsia, or eclampsia.
Results
Among 877 pregnant women, the risk of developing pregnancy‐associated HTN was significantly increased in women with NAFLD compared to those without NAFLD. Grade 2‐3 steatosis was a significant predictor of pregnancy‐associated HTN, even after adjustment for metabolic risk factors. Circulating levels of SeP were significantly higher in women with versus those without NAFLD (P = .001) and was significantly higher also in women who subsequently developed pregnancy‐associated HTN compared with those who did not (P |
| doi_str_mv | 10.1111/liv.14563 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2415284235</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2445001283</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4233-b3e66f286c7851b3803f739eb5db409ef9d2eb84c6a2fe6f1635c85231fc4a523</originalsourceid><addsrcrecordid>eNp1kL9OwzAQxi0EoqUw8ALIEgsMaWM7Tp0RVfypVIkFGIkc50xd0rjYKVU2HoFn5ElwaemAxA13N_z03X0fQqck7pNQg8q890nCU7aHuiQZiohRRvZ3O2UddOT9LI5JlnFyiDqMci6IyLro-WEK2Bn_iq3GCwcvtaxV-_XxKb23ysgGSjxtF-AaqL2xNTY1Xtk5hG6aKa5tLStlp7YyCmvZNC0Oz4DDpfEgPRyjAy0rDyfb2UOPN9cPo7tocn87Hl1NIpVQxqKCQZpqKlI1FJwUTMRMD1kGBS-LJM5AZyWFQiQqlVRDqknKuBI8uNQqkWH20MVGd-Hs2xJ8k8-NV1BVsga79DlNCKci3OIBPf-DzuzSBRtrKuEhJCpYoC43lHLWewc6Xzgzl67NSZyvQ8-Dz_wn9MCebRWXxRzKHfmbcgAGG2BlKmj_V8on46eN5DcLrIzH</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2445001283</pqid></control><display><type>article</type><title>The risk of pregnancy‐associated hypertension in women with nonalcoholic fatty liver disease</title><source>Wiley Online Library All Journals</source><creator>Jung, Young Mi ; Lee, Seung Mi ; Hong, Subeen ; Koo, Ja Nam ; Oh, Ig Hwan ; Kim, Byoung Jae ; Kim, Sun Min ; Kim, Sang Youn ; Kim, Gyoung Min ; Kyung Joo, Sae ; Shin, Sue ; Norwitz, Errol R. ; Park, Chan‐Wook ; Jun, Jong Kwan ; Kim, Won ; Park, Joong Shin</creator><creatorcontrib>Jung, Young Mi ; Lee, Seung Mi ; Hong, Subeen ; Koo, Ja Nam ; Oh, Ig Hwan ; Kim, Byoung Jae ; Kim, Sun Min ; Kim, Sang Youn ; Kim, Gyoung Min ; Kyung Joo, Sae ; Shin, Sue ; Norwitz, Errol R. ; Park, Chan‐Wook ; Jun, Jong Kwan ; Kim, Won ; Park, Joong Shin</creatorcontrib><description>Background & Aims
Nonalcoholic fatty liver disease (NAFLD) is an independent predictor of cardiovascular disease (CVD) in non‐pregnant adults. Although the biological mechanisms underlying this association are not completely understood, metabolic factors, inflammation, and endothelial dysfunction are likely all involved. The association between NAFLD and pregnancy‐associated hypertension (HTN) has not been systematically examined. The aim of this study is to assess the risk of pregnancy‐associated HTN in pregnant women with NAFLD.
Methods
This is secondary analysis of a prospective study of healthy pregnant women. Liver ultrasonography was performed at 10‐14 weeks of gestation and maternal blood was taken for the measurement of selenoprotein P (SeP), a hepatokine independently associated with both NAFLD and CVD. Pregnancy‐associated HTN was defined as the development of gestational HTN, preeclampsia, or eclampsia.
Results
Among 877 pregnant women, the risk of developing pregnancy‐associated HTN was significantly increased in women with NAFLD compared to those without NAFLD. Grade 2‐3 steatosis was a significant predictor of pregnancy‐associated HTN, even after adjustment for metabolic risk factors. Circulating levels of SeP were significantly higher in women with versus those without NAFLD (P = .001) and was significantly higher also in women who subsequently developed pregnancy‐associated HTN compared with those who did not (P < .005).
Conclusions
Sonographic evidence of NAFLD at 10‐14 weeks is an independent predictor of pregnancy‐associated HTN. Circulating levels of SeP at that same gestational age are significantly increased in pregnant women with NAFLD who subsequently develop pregnancy‐associated HTN.</description><identifier>ISSN: 1478-3223</identifier><identifier>EISSN: 1478-3231</identifier><identifier>DOI: 10.1111/liv.14563</identifier><identifier>PMID: 32558189</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Cardiovascular diseases ; Fatty liver ; Gestation ; Gestational age ; Heart diseases ; Hypertension ; Liver ; Liver diseases ; Metabolism ; nonalcoholic fatty liver disease ; Pre-eclampsia ; Pregnancy ; pregnancy‐associated hypertension ; Risk analysis ; Risk factors ; Secondary analysis ; selenoprotein P ; Steatosis ; Womens health</subject><ispartof>Liver international, 2020-10, Vol.40 (10), p.2417-2426</ispartof><rights>2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>2020 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4233-b3e66f286c7851b3803f739eb5db409ef9d2eb84c6a2fe6f1635c85231fc4a523</citedby><cites>FETCH-LOGICAL-c4233-b3e66f286c7851b3803f739eb5db409ef9d2eb84c6a2fe6f1635c85231fc4a523</cites><orcidid>0000-0002-2926-1007</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fliv.14563$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fliv.14563$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32558189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jung, Young Mi</creatorcontrib><creatorcontrib>Lee, Seung Mi</creatorcontrib><creatorcontrib>Hong, Subeen</creatorcontrib><creatorcontrib>Koo, Ja Nam</creatorcontrib><creatorcontrib>Oh, Ig Hwan</creatorcontrib><creatorcontrib>Kim, Byoung Jae</creatorcontrib><creatorcontrib>Kim, Sun Min</creatorcontrib><creatorcontrib>Kim, Sang Youn</creatorcontrib><creatorcontrib>Kim, Gyoung Min</creatorcontrib><creatorcontrib>Kyung Joo, Sae</creatorcontrib><creatorcontrib>Shin, Sue</creatorcontrib><creatorcontrib>Norwitz, Errol R.</creatorcontrib><creatorcontrib>Park, Chan‐Wook</creatorcontrib><creatorcontrib>Jun, Jong Kwan</creatorcontrib><creatorcontrib>Kim, Won</creatorcontrib><creatorcontrib>Park, Joong Shin</creatorcontrib><title>The risk of pregnancy‐associated hypertension in women with nonalcoholic fatty liver disease</title><title>Liver international</title><addtitle>Liver Int</addtitle><description>Background & Aims
Nonalcoholic fatty liver disease (NAFLD) is an independent predictor of cardiovascular disease (CVD) in non‐pregnant adults. Although the biological mechanisms underlying this association are not completely understood, metabolic factors, inflammation, and endothelial dysfunction are likely all involved. The association between NAFLD and pregnancy‐associated hypertension (HTN) has not been systematically examined. The aim of this study is to assess the risk of pregnancy‐associated HTN in pregnant women with NAFLD.
Methods
This is secondary analysis of a prospective study of healthy pregnant women. Liver ultrasonography was performed at 10‐14 weeks of gestation and maternal blood was taken for the measurement of selenoprotein P (SeP), a hepatokine independently associated with both NAFLD and CVD. Pregnancy‐associated HTN was defined as the development of gestational HTN, preeclampsia, or eclampsia.
Results
Among 877 pregnant women, the risk of developing pregnancy‐associated HTN was significantly increased in women with NAFLD compared to those without NAFLD. Grade 2‐3 steatosis was a significant predictor of pregnancy‐associated HTN, even after adjustment for metabolic risk factors. Circulating levels of SeP were significantly higher in women with versus those without NAFLD (P = .001) and was significantly higher also in women who subsequently developed pregnancy‐associated HTN compared with those who did not (P < .005).
Conclusions
Sonographic evidence of NAFLD at 10‐14 weeks is an independent predictor of pregnancy‐associated HTN. Circulating levels of SeP at that same gestational age are significantly increased in pregnant women with NAFLD who subsequently develop pregnancy‐associated HTN.</description><subject>Cardiovascular diseases</subject><subject>Fatty liver</subject><subject>Gestation</subject><subject>Gestational age</subject><subject>Heart diseases</subject><subject>Hypertension</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>Metabolism</subject><subject>nonalcoholic fatty liver disease</subject><subject>Pre-eclampsia</subject><subject>Pregnancy</subject><subject>pregnancy‐associated hypertension</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Secondary analysis</subject><subject>selenoprotein P</subject><subject>Steatosis</subject><subject>Womens health</subject><issn>1478-3223</issn><issn>1478-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kL9OwzAQxi0EoqUw8ALIEgsMaWM7Tp0RVfypVIkFGIkc50xd0rjYKVU2HoFn5ElwaemAxA13N_z03X0fQqck7pNQg8q890nCU7aHuiQZiohRRvZ3O2UddOT9LI5JlnFyiDqMci6IyLro-WEK2Bn_iq3GCwcvtaxV-_XxKb23ysgGSjxtF-AaqL2xNTY1Xtk5hG6aKa5tLStlp7YyCmvZNC0Oz4DDpfEgPRyjAy0rDyfb2UOPN9cPo7tocn87Hl1NIpVQxqKCQZpqKlI1FJwUTMRMD1kGBS-LJM5AZyWFQiQqlVRDqknKuBI8uNQqkWH20MVGd-Hs2xJ8k8-NV1BVsga79DlNCKci3OIBPf-DzuzSBRtrKuEhJCpYoC43lHLWewc6Xzgzl67NSZyvQ8-Dz_wn9MCebRWXxRzKHfmbcgAGG2BlKmj_V8on46eN5DcLrIzH</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Jung, Young Mi</creator><creator>Lee, Seung Mi</creator><creator>Hong, Subeen</creator><creator>Koo, Ja Nam</creator><creator>Oh, Ig Hwan</creator><creator>Kim, Byoung Jae</creator><creator>Kim, Sun Min</creator><creator>Kim, Sang Youn</creator><creator>Kim, Gyoung Min</creator><creator>Kyung Joo, Sae</creator><creator>Shin, Sue</creator><creator>Norwitz, Errol R.</creator><creator>Park, Chan‐Wook</creator><creator>Jun, Jong Kwan</creator><creator>Kim, Won</creator><creator>Park, Joong Shin</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2926-1007</orcidid></search><sort><creationdate>202010</creationdate><title>The risk of pregnancy‐associated hypertension in women with nonalcoholic fatty liver disease</title><author>Jung, Young Mi ; Lee, Seung Mi ; Hong, Subeen ; Koo, Ja Nam ; Oh, Ig Hwan ; Kim, Byoung Jae ; Kim, Sun Min ; Kim, Sang Youn ; Kim, Gyoung Min ; Kyung Joo, Sae ; Shin, Sue ; Norwitz, Errol R. ; Park, Chan‐Wook ; Jun, Jong Kwan ; Kim, Won ; Park, Joong Shin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4233-b3e66f286c7851b3803f739eb5db409ef9d2eb84c6a2fe6f1635c85231fc4a523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cardiovascular diseases</topic><topic>Fatty liver</topic><topic>Gestation</topic><topic>Gestational age</topic><topic>Heart diseases</topic><topic>Hypertension</topic><topic>Liver</topic><topic>Liver diseases</topic><topic>Metabolism</topic><topic>nonalcoholic fatty liver disease</topic><topic>Pre-eclampsia</topic><topic>Pregnancy</topic><topic>pregnancy‐associated hypertension</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Secondary analysis</topic><topic>selenoprotein P</topic><topic>Steatosis</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jung, Young Mi</creatorcontrib><creatorcontrib>Lee, Seung Mi</creatorcontrib><creatorcontrib>Hong, Subeen</creatorcontrib><creatorcontrib>Koo, Ja Nam</creatorcontrib><creatorcontrib>Oh, Ig Hwan</creatorcontrib><creatorcontrib>Kim, Byoung Jae</creatorcontrib><creatorcontrib>Kim, Sun Min</creatorcontrib><creatorcontrib>Kim, Sang Youn</creatorcontrib><creatorcontrib>Kim, Gyoung Min</creatorcontrib><creatorcontrib>Kyung Joo, Sae</creatorcontrib><creatorcontrib>Shin, Sue</creatorcontrib><creatorcontrib>Norwitz, Errol R.</creatorcontrib><creatorcontrib>Park, Chan‐Wook</creatorcontrib><creatorcontrib>Jun, Jong Kwan</creatorcontrib><creatorcontrib>Kim, Won</creatorcontrib><creatorcontrib>Park, Joong Shin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Liver international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jung, Young Mi</au><au>Lee, Seung Mi</au><au>Hong, Subeen</au><au>Koo, Ja Nam</au><au>Oh, Ig Hwan</au><au>Kim, Byoung Jae</au><au>Kim, Sun Min</au><au>Kim, Sang Youn</au><au>Kim, Gyoung Min</au><au>Kyung Joo, Sae</au><au>Shin, Sue</au><au>Norwitz, Errol R.</au><au>Park, Chan‐Wook</au><au>Jun, Jong Kwan</au><au>Kim, Won</au><au>Park, Joong Shin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The risk of pregnancy‐associated hypertension in women with nonalcoholic fatty liver disease</atitle><jtitle>Liver international</jtitle><addtitle>Liver Int</addtitle><date>2020-10</date><risdate>2020</risdate><volume>40</volume><issue>10</issue><spage>2417</spage><epage>2426</epage><pages>2417-2426</pages><issn>1478-3223</issn><eissn>1478-3231</eissn><abstract>Background & Aims
Nonalcoholic fatty liver disease (NAFLD) is an independent predictor of cardiovascular disease (CVD) in non‐pregnant adults. Although the biological mechanisms underlying this association are not completely understood, metabolic factors, inflammation, and endothelial dysfunction are likely all involved. The association between NAFLD and pregnancy‐associated hypertension (HTN) has not been systematically examined. The aim of this study is to assess the risk of pregnancy‐associated HTN in pregnant women with NAFLD.
Methods
This is secondary analysis of a prospective study of healthy pregnant women. Liver ultrasonography was performed at 10‐14 weeks of gestation and maternal blood was taken for the measurement of selenoprotein P (SeP), a hepatokine independently associated with both NAFLD and CVD. Pregnancy‐associated HTN was defined as the development of gestational HTN, preeclampsia, or eclampsia.
Results
Among 877 pregnant women, the risk of developing pregnancy‐associated HTN was significantly increased in women with NAFLD compared to those without NAFLD. Grade 2‐3 steatosis was a significant predictor of pregnancy‐associated HTN, even after adjustment for metabolic risk factors. Circulating levels of SeP were significantly higher in women with versus those without NAFLD (P = .001) and was significantly higher also in women who subsequently developed pregnancy‐associated HTN compared with those who did not (P < .005).
Conclusions
Sonographic evidence of NAFLD at 10‐14 weeks is an independent predictor of pregnancy‐associated HTN. Circulating levels of SeP at that same gestational age are significantly increased in pregnant women with NAFLD who subsequently develop pregnancy‐associated HTN.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32558189</pmid><doi>10.1111/liv.14563</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-2926-1007</orcidid></addata></record> |
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| ispartof | Liver international, 2020-10, Vol.40 (10), p.2417-2426 |
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| source | Wiley Online Library All Journals |
| subjects | Cardiovascular diseases Fatty liver Gestation Gestational age Heart diseases Hypertension Liver Liver diseases Metabolism nonalcoholic fatty liver disease Pre-eclampsia Pregnancy pregnancy‐associated hypertension Risk analysis Risk factors Secondary analysis selenoprotein P Steatosis Womens health |
| title | The risk of pregnancy‐associated hypertension in women with nonalcoholic fatty liver disease |
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