Antidepressant-Like Effects of CX717, a Positive Allosteric Modulator of AMPA Receptors

Conventional antidepressant drugs elevate the availability of monoamine neurotransmitters. However, these pharmacological therapies have limited efficacy and a slow onset of action as main limitations. New glutamatergic drugs such as ketamine have shown promise as a rapid-acting antidepressant drugs...

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Veröffentlicht in:	Molecular neurobiology 2020-08, Vol.57 (8), p.3498-3507
Hauptverfasser:	Gordillo-Salas, Marta, Pascual-Antón, Raquel, Ren, Jun, Greer, John, Adell, Albert
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric properties Antidepressants Biomedical and Life Sciences Biomedicine Brain-derived neurotrophic factor Cell Biology Dopamine Drugs Glutamatergic transmission Ketamine Monoamines Neurobiology Neurology Neuromodulation Neurosciences Neurotransmitters Norepinephrine Original Article Pyramidal cells Serotonin α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
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