Abstinent patients with alcohol use disorders show an altered plasma cytokine profile: Identification of both interleukin 6 and interleukin 17A as potential biomarkers of consumption and comorbid liver and pancreatic diseases
Background: Recent studies have demonstrated that alcohol consumption can modulate the immune system by directly activating natural immunity and triggering inflammatory processes in the central nervous system and in peripheral organs, such as the liver and pancreas. Patients with alcohol use disorde...
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| Veröffentlicht in: | Journal of psychopharmacology (Oxford) 2020-11, Vol.34 (11), p.1250-1260 |
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| container_title | Journal of psychopharmacology (Oxford) |
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| creator | García-Marchena, Nuria Maza-Quiroga, Rosa Serrano, Antonia Barrios, Vicente Requena-Ocaña, Nerea Suárez, Juan Chowen, Julie Ann Argente, Jesús Rubio, Gabriel Torrens, Marta López-Gallardo, Meritxell Marco, Eva María Castilla-Ortega, Estela Santín, Luis Javier Rodríguez de Fonseca, Fernando Pavón, Francisco Javier Araos, Pedro |
| description | Background:
Recent studies have demonstrated that alcohol consumption can modulate the immune system by directly activating natural immunity and triggering inflammatory processes in the central nervous system and in peripheral organs, such as the liver and pancreas. Patients with alcohol use disorders have an elevated frequency of comorbid mental disorders and gut diseases (i.e. fatty liver and pancreatitis) that complicate diagnosis, treatment and prognosis.
Aims:
The present study aims to explore possible associations in circulating plasma cytokine concentrations in abstinent patients diagnosed with alcohol use disorders.
Methods:
To this end, 85 abstinent subjects with alcohol use disorders from an outpatient setting and 55 healthy subjects were evaluated for both substance and mental disorders. The plasma levels of cytokines interleukin 1 beta, interleukin 4, interleukin 6, interleukin 17A, interferon gamma and tumour necrosis alpha were determined and their association with (a) history of alcohol consumption, (b) psychiatric comorbidity and (c) liver/pancreas comorbidities was explored.
Results:
We found that plasma concentrations of interleukin 1 beta, interleukin 6 and tumour necrosis alpha were increased, whereas plasma concentrations of interleukin 4, interleukin 17A and interferon gamma were decreased in abstinent alcohol use disorder patients as compared with control subjects. Moreover, we found that changes in interleukin 6 and interleukin 17A plasma concentrations in alcohol use disorder patients were associated with the presence of liver and pancreatic diseases.
Conclusion:
The present results suggest alcohol use disorder is associated with alterations of plasma cytokines, being interleukin 6 and interleukin 17A potential biomarkers of the presence of comorbidities of digestive organs. The clinical relevance of these findings is discussed in the context of alcohol-induced inflammatory processes. |
| doi_str_mv | 10.1177/0269881120928176 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2413999198</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0269881120928176</sage_id><sourcerecordid>2455477647</sourcerecordid><originalsourceid>FETCH-LOGICAL-c365t-5fa13bd245a9c38dc5b52a0fc7cf775bbe9ba1b30d481d07b4762e4e4931876a3</originalsourceid><addsrcrecordid>eNp1kUtv1TAQRi0EopfCnhWyxIZNwE78SNhdVTwqVWID68iPCdetEwdP0qo_l3-C01tAVGJjS57znRl5CHnJ2VvOtX7HatW1Lec16-qWa_WI7LhQvNJ1Kx-T3VautvoJeYZ4yRhXQsmn5KSpZaPKsSM_9xaXMMG00NksodxIb8JyoCa6dEiRrgjUB0zZQ0aKh3RDzVSqC2TwdI4GR0Pd7ZKuioXOOQ0hwnt67osqDMEVaZpoGqhNxRqmkouwFpiqIvL_vHC9pwbpnJYtbCK1IY0mX22di8GlCddxvhNuUZfGlG3wNIZryHdPs5lchtLTbUODQcDn5MlgIsKL-_uUfPv44evZ5-riy6fzs_1F5Roll0oOhjfW10KazjWtd9LK2rDBaTdoLa2FzhpuG-ZFyz3TVmhVgwDRNbzVyjSn5M3RW_7gxwq49GNABzGaCdKKfS1403Ud79qCvn6AXqY1T2W6QkkptFZCF4odKZcTYoahn3Mo33Hbc9Zv6-8frr9EXt2LVzuC_xP4ve8CVEcAzXf42_W_wl-cuL0I</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2455477647</pqid></control><display><type>article</type><title>Abstinent patients with alcohol use disorders show an altered plasma cytokine profile: Identification of both interleukin 6 and interleukin 17A as potential biomarkers of consumption and comorbid liver and pancreatic diseases</title><source>SAGE Complete</source><creator>García-Marchena, Nuria ; Maza-Quiroga, Rosa ; Serrano, Antonia ; Barrios, Vicente ; Requena-Ocaña, Nerea ; Suárez, Juan ; Chowen, Julie Ann ; Argente, Jesús ; Rubio, Gabriel ; Torrens, Marta ; López-Gallardo, Meritxell ; Marco, Eva María ; Castilla-Ortega, Estela ; Santín, Luis Javier ; Rodríguez de Fonseca, Fernando ; Pavón, Francisco Javier ; Araos, Pedro</creator><creatorcontrib>García-Marchena, Nuria ; Maza-Quiroga, Rosa ; Serrano, Antonia ; Barrios, Vicente ; Requena-Ocaña, Nerea ; Suárez, Juan ; Chowen, Julie Ann ; Argente, Jesús ; Rubio, Gabriel ; Torrens, Marta ; López-Gallardo, Meritxell ; Marco, Eva María ; Castilla-Ortega, Estela ; Santín, Luis Javier ; Rodríguez de Fonseca, Fernando ; Pavón, Francisco Javier ; Araos, Pedro</creatorcontrib><description>Background:
Recent studies have demonstrated that alcohol consumption can modulate the immune system by directly activating natural immunity and triggering inflammatory processes in the central nervous system and in peripheral organs, such as the liver and pancreas. Patients with alcohol use disorders have an elevated frequency of comorbid mental disorders and gut diseases (i.e. fatty liver and pancreatitis) that complicate diagnosis, treatment and prognosis.
Aims:
The present study aims to explore possible associations in circulating plasma cytokine concentrations in abstinent patients diagnosed with alcohol use disorders.
Methods:
To this end, 85 abstinent subjects with alcohol use disorders from an outpatient setting and 55 healthy subjects were evaluated for both substance and mental disorders. The plasma levels of cytokines interleukin 1 beta, interleukin 4, interleukin 6, interleukin 17A, interferon gamma and tumour necrosis alpha were determined and their association with (a) history of alcohol consumption, (b) psychiatric comorbidity and (c) liver/pancreas comorbidities was explored.
Results:
We found that plasma concentrations of interleukin 1 beta, interleukin 6 and tumour necrosis alpha were increased, whereas plasma concentrations of interleukin 4, interleukin 17A and interferon gamma were decreased in abstinent alcohol use disorder patients as compared with control subjects. Moreover, we found that changes in interleukin 6 and interleukin 17A plasma concentrations in alcohol use disorder patients were associated with the presence of liver and pancreatic diseases.
Conclusion:
The present results suggest alcohol use disorder is associated with alterations of plasma cytokines, being interleukin 6 and interleukin 17A potential biomarkers of the presence of comorbidities of digestive organs. The clinical relevance of these findings is discussed in the context of alcohol-induced inflammatory processes.</description><identifier>ISSN: 0269-8811</identifier><identifier>EISSN: 1461-7285</identifier><identifier>DOI: 10.1177/0269881120928176</identifier><identifier>PMID: 32536325</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Alcohol use ; Biomarkers ; Central nervous system ; Comorbidity ; Cytokines ; Fatty liver ; Immune system ; Inflammation ; Interferon ; Interleukin 1 ; Interleukin 4 ; Interleukin 6 ; Liver ; Liver diseases ; Mental disorders ; Necrosis ; Pancreas ; Pancreatic diseases ; Pancreatitis ; Patients ; Plasma ; Plasma levels ; Tumors</subject><ispartof>Journal of psychopharmacology (Oxford), 2020-11, Vol.34 (11), p.1250-1260</ispartof><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-5fa13bd245a9c38dc5b52a0fc7cf775bbe9ba1b30d481d07b4762e4e4931876a3</citedby><cites>FETCH-LOGICAL-c365t-5fa13bd245a9c38dc5b52a0fc7cf775bbe9ba1b30d481d07b4762e4e4931876a3</cites><orcidid>0000-0001-5172-8796</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0269881120928176$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0269881120928176$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32536325$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>García-Marchena, Nuria</creatorcontrib><creatorcontrib>Maza-Quiroga, Rosa</creatorcontrib><creatorcontrib>Serrano, Antonia</creatorcontrib><creatorcontrib>Barrios, Vicente</creatorcontrib><creatorcontrib>Requena-Ocaña, Nerea</creatorcontrib><creatorcontrib>Suárez, Juan</creatorcontrib><creatorcontrib>Chowen, Julie Ann</creatorcontrib><creatorcontrib>Argente, Jesús</creatorcontrib><creatorcontrib>Rubio, Gabriel</creatorcontrib><creatorcontrib>Torrens, Marta</creatorcontrib><creatorcontrib>López-Gallardo, Meritxell</creatorcontrib><creatorcontrib>Marco, Eva María</creatorcontrib><creatorcontrib>Castilla-Ortega, Estela</creatorcontrib><creatorcontrib>Santín, Luis Javier</creatorcontrib><creatorcontrib>Rodríguez de Fonseca, Fernando</creatorcontrib><creatorcontrib>Pavón, Francisco Javier</creatorcontrib><creatorcontrib>Araos, Pedro</creatorcontrib><title>Abstinent patients with alcohol use disorders show an altered plasma cytokine profile: Identification of both interleukin 6 and interleukin 17A as potential biomarkers of consumption and comorbid liver and pancreatic diseases</title><title>Journal of psychopharmacology (Oxford)</title><addtitle>J Psychopharmacol</addtitle><description>Background:
Recent studies have demonstrated that alcohol consumption can modulate the immune system by directly activating natural immunity and triggering inflammatory processes in the central nervous system and in peripheral organs, such as the liver and pancreas. Patients with alcohol use disorders have an elevated frequency of comorbid mental disorders and gut diseases (i.e. fatty liver and pancreatitis) that complicate diagnosis, treatment and prognosis.
Aims:
The present study aims to explore possible associations in circulating plasma cytokine concentrations in abstinent patients diagnosed with alcohol use disorders.
Methods:
To this end, 85 abstinent subjects with alcohol use disorders from an outpatient setting and 55 healthy subjects were evaluated for both substance and mental disorders. The plasma levels of cytokines interleukin 1 beta, interleukin 4, interleukin 6, interleukin 17A, interferon gamma and tumour necrosis alpha were determined and their association with (a) history of alcohol consumption, (b) psychiatric comorbidity and (c) liver/pancreas comorbidities was explored.
Results:
We found that plasma concentrations of interleukin 1 beta, interleukin 6 and tumour necrosis alpha were increased, whereas plasma concentrations of interleukin 4, interleukin 17A and interferon gamma were decreased in abstinent alcohol use disorder patients as compared with control subjects. Moreover, we found that changes in interleukin 6 and interleukin 17A plasma concentrations in alcohol use disorder patients were associated with the presence of liver and pancreatic diseases.
Conclusion:
The present results suggest alcohol use disorder is associated with alterations of plasma cytokines, being interleukin 6 and interleukin 17A potential biomarkers of the presence of comorbidities of digestive organs. The clinical relevance of these findings is discussed in the context of alcohol-induced inflammatory processes.</description><subject>Alcohol use</subject><subject>Biomarkers</subject><subject>Central nervous system</subject><subject>Comorbidity</subject><subject>Cytokines</subject><subject>Fatty liver</subject><subject>Immune system</subject><subject>Inflammation</subject><subject>Interferon</subject><subject>Interleukin 1</subject><subject>Interleukin 4</subject><subject>Interleukin 6</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>Mental disorders</subject><subject>Necrosis</subject><subject>Pancreas</subject><subject>Pancreatic diseases</subject><subject>Pancreatitis</subject><subject>Patients</subject><subject>Plasma</subject><subject>Plasma levels</subject><subject>Tumors</subject><issn>0269-8811</issn><issn>1461-7285</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kUtv1TAQRi0EopfCnhWyxIZNwE78SNhdVTwqVWID68iPCdetEwdP0qo_l3-C01tAVGJjS57znRl5CHnJ2VvOtX7HatW1Lec16-qWa_WI7LhQvNJ1Kx-T3VautvoJeYZ4yRhXQsmn5KSpZaPKsSM_9xaXMMG00NksodxIb8JyoCa6dEiRrgjUB0zZQ0aKh3RDzVSqC2TwdI4GR0Pd7ZKuioXOOQ0hwnt67osqDMEVaZpoGqhNxRqmkouwFpiqIvL_vHC9pwbpnJYtbCK1IY0mX22di8GlCddxvhNuUZfGlG3wNIZryHdPs5lchtLTbUODQcDn5MlgIsKL-_uUfPv44evZ5-riy6fzs_1F5Roll0oOhjfW10KazjWtd9LK2rDBaTdoLa2FzhpuG-ZFyz3TVmhVgwDRNbzVyjSn5M3RW_7gxwq49GNABzGaCdKKfS1403Ud79qCvn6AXqY1T2W6QkkptFZCF4odKZcTYoahn3Mo33Hbc9Zv6-8frr9EXt2LVzuC_xP4ve8CVEcAzXf42_W_wl-cuL0I</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>García-Marchena, Nuria</creator><creator>Maza-Quiroga, Rosa</creator><creator>Serrano, Antonia</creator><creator>Barrios, Vicente</creator><creator>Requena-Ocaña, Nerea</creator><creator>Suárez, Juan</creator><creator>Chowen, Julie Ann</creator><creator>Argente, Jesús</creator><creator>Rubio, Gabriel</creator><creator>Torrens, Marta</creator><creator>López-Gallardo, Meritxell</creator><creator>Marco, Eva María</creator><creator>Castilla-Ortega, Estela</creator><creator>Santín, Luis Javier</creator><creator>Rodríguez de Fonseca, Fernando</creator><creator>Pavón, Francisco Javier</creator><creator>Araos, Pedro</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5172-8796</orcidid></search><sort><creationdate>202011</creationdate><title>Abstinent patients with alcohol use disorders show an altered plasma cytokine profile: Identification of both interleukin 6 and interleukin 17A as potential biomarkers of consumption and comorbid liver and pancreatic diseases</title><author>García-Marchena, Nuria ; Maza-Quiroga, Rosa ; Serrano, Antonia ; Barrios, Vicente ; Requena-Ocaña, Nerea ; Suárez, Juan ; Chowen, Julie Ann ; Argente, Jesús ; Rubio, Gabriel ; Torrens, Marta ; López-Gallardo, Meritxell ; Marco, Eva María ; Castilla-Ortega, Estela ; Santín, Luis Javier ; Rodríguez de Fonseca, Fernando ; Pavón, Francisco Javier ; Araos, Pedro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-5fa13bd245a9c38dc5b52a0fc7cf775bbe9ba1b30d481d07b4762e4e4931876a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Alcohol use</topic><topic>Biomarkers</topic><topic>Central nervous system</topic><topic>Comorbidity</topic><topic>Cytokines</topic><topic>Fatty liver</topic><topic>Immune system</topic><topic>Inflammation</topic><topic>Interferon</topic><topic>Interleukin 1</topic><topic>Interleukin 4</topic><topic>Interleukin 6</topic><topic>Liver</topic><topic>Liver diseases</topic><topic>Mental disorders</topic><topic>Necrosis</topic><topic>Pancreas</topic><topic>Pancreatic diseases</topic><topic>Pancreatitis</topic><topic>Patients</topic><topic>Plasma</topic><topic>Plasma levels</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>García-Marchena, Nuria</creatorcontrib><creatorcontrib>Maza-Quiroga, Rosa</creatorcontrib><creatorcontrib>Serrano, Antonia</creatorcontrib><creatorcontrib>Barrios, Vicente</creatorcontrib><creatorcontrib>Requena-Ocaña, Nerea</creatorcontrib><creatorcontrib>Suárez, Juan</creatorcontrib><creatorcontrib>Chowen, Julie Ann</creatorcontrib><creatorcontrib>Argente, Jesús</creatorcontrib><creatorcontrib>Rubio, Gabriel</creatorcontrib><creatorcontrib>Torrens, Marta</creatorcontrib><creatorcontrib>López-Gallardo, Meritxell</creatorcontrib><creatorcontrib>Marco, Eva María</creatorcontrib><creatorcontrib>Castilla-Ortega, Estela</creatorcontrib><creatorcontrib>Santín, Luis Javier</creatorcontrib><creatorcontrib>Rodríguez de Fonseca, Fernando</creatorcontrib><creatorcontrib>Pavón, Francisco Javier</creatorcontrib><creatorcontrib>Araos, Pedro</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of psychopharmacology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>García-Marchena, Nuria</au><au>Maza-Quiroga, Rosa</au><au>Serrano, Antonia</au><au>Barrios, Vicente</au><au>Requena-Ocaña, Nerea</au><au>Suárez, Juan</au><au>Chowen, Julie Ann</au><au>Argente, Jesús</au><au>Rubio, Gabriel</au><au>Torrens, Marta</au><au>López-Gallardo, Meritxell</au><au>Marco, Eva María</au><au>Castilla-Ortega, Estela</au><au>Santín, Luis Javier</au><au>Rodríguez de Fonseca, Fernando</au><au>Pavón, Francisco Javier</au><au>Araos, Pedro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abstinent patients with alcohol use disorders show an altered plasma cytokine profile: Identification of both interleukin 6 and interleukin 17A as potential biomarkers of consumption and comorbid liver and pancreatic diseases</atitle><jtitle>Journal of psychopharmacology (Oxford)</jtitle><addtitle>J Psychopharmacol</addtitle><date>2020-11</date><risdate>2020</risdate><volume>34</volume><issue>11</issue><spage>1250</spage><epage>1260</epage><pages>1250-1260</pages><issn>0269-8811</issn><eissn>1461-7285</eissn><abstract>Background:
Recent studies have demonstrated that alcohol consumption can modulate the immune system by directly activating natural immunity and triggering inflammatory processes in the central nervous system and in peripheral organs, such as the liver and pancreas. Patients with alcohol use disorders have an elevated frequency of comorbid mental disorders and gut diseases (i.e. fatty liver and pancreatitis) that complicate diagnosis, treatment and prognosis.
Aims:
The present study aims to explore possible associations in circulating plasma cytokine concentrations in abstinent patients diagnosed with alcohol use disorders.
Methods:
To this end, 85 abstinent subjects with alcohol use disorders from an outpatient setting and 55 healthy subjects were evaluated for both substance and mental disorders. The plasma levels of cytokines interleukin 1 beta, interleukin 4, interleukin 6, interleukin 17A, interferon gamma and tumour necrosis alpha were determined and their association with (a) history of alcohol consumption, (b) psychiatric comorbidity and (c) liver/pancreas comorbidities was explored.
Results:
We found that plasma concentrations of interleukin 1 beta, interleukin 6 and tumour necrosis alpha were increased, whereas plasma concentrations of interleukin 4, interleukin 17A and interferon gamma were decreased in abstinent alcohol use disorder patients as compared with control subjects. Moreover, we found that changes in interleukin 6 and interleukin 17A plasma concentrations in alcohol use disorder patients were associated with the presence of liver and pancreatic diseases.
Conclusion:
The present results suggest alcohol use disorder is associated with alterations of plasma cytokines, being interleukin 6 and interleukin 17A potential biomarkers of the presence of comorbidities of digestive organs. The clinical relevance of these findings is discussed in the context of alcohol-induced inflammatory processes.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>32536325</pmid><doi>10.1177/0269881120928176</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-5172-8796</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0269-8811 |
| ispartof | Journal of psychopharmacology (Oxford), 2020-11, Vol.34 (11), p.1250-1260 |
| issn | 0269-8811 1461-7285 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2413999198 |
| source | SAGE Complete |
| subjects | Alcohol use Biomarkers Central nervous system Comorbidity Cytokines Fatty liver Immune system Inflammation Interferon Interleukin 1 Interleukin 4 Interleukin 6 Liver Liver diseases Mental disorders Necrosis Pancreas Pancreatic diseases Pancreatitis Patients Plasma Plasma levels Tumors |
| title | Abstinent patients with alcohol use disorders show an altered plasma cytokine profile: Identification of both interleukin 6 and interleukin 17A as potential biomarkers of consumption and comorbid liver and pancreatic diseases |
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