Serum and Saliva Levels of Cancer Antigen 15-3, Carcinoembryonic Antigen, Estradiol, Vaspin, and Obestatin as Biomarkers for the Diagnosis of Breast Cancer in Postmenopausal Women
Abstract Objective To find suitable biomarkers for diagnosis of Breast cancer in serum and saliva; also, to examine the correlation between salivary and serum concentrations of suitable biomarkers. Methods This case-control study included 30 women with breast cancer as a case group and 30 healthy wo...
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| Veröffentlicht in: | Laboratory medicine 2020-11, Vol.51 (6), p.620-627 |
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| creator | Farahani, Hyder Amri, Jamal Alaee, Mona Mohaghegh, Fathollah Rafiee, Mohammad |
| description | Abstract
Objective
To find suitable biomarkers for diagnosis of Breast cancer in serum and saliva; also, to examine the correlation between salivary and serum concentrations of suitable biomarkers.
Methods
This case-control study included 30 women with breast cancer as a case group and 30 healthy women as a matched control group. Blood and saliva specimens were collected from all participants. We evaluated serum and salivary cancer antigen 15-3 (CA15-3), carcinoembryonic antigen (CEA), estradiol, vaspin, and obestatin concentrations. Mann-Whitney U testing and Spearman correlation coefficients were used for statistical analysis.
Results
Serum and salivary concentrations of estradiol were significantly higher in patients with breast cancer (BC) than in healthy women (P < .05). Also, serum CEA and salivary obestatin concentrations were significantly higher in BC patients than in the control group (P < .05). However, there was no significant difference between other parameters in patients with BC and controls. We observed a positive correlation between serum and salivary concentrations of CA15-3, as well as a negative correlation between serum and salivary concentrations of vaspin and obestatin.
Conclusion
The results of this study demonstrated that concentrations of CEA and estradiol in serum, obestatin in serum and saliva, and estradiol in saliva were significantly different between the 2 groups. |
| doi_str_mv | 10.1093/labmed/lmaa013 |
| format | Article |
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Objective
To find suitable biomarkers for diagnosis of Breast cancer in serum and saliva; also, to examine the correlation between salivary and serum concentrations of suitable biomarkers.
Methods
This case-control study included 30 women with breast cancer as a case group and 30 healthy women as a matched control group. Blood and saliva specimens were collected from all participants. We evaluated serum and salivary cancer antigen 15-3 (CA15-3), carcinoembryonic antigen (CEA), estradiol, vaspin, and obestatin concentrations. Mann-Whitney U testing and Spearman correlation coefficients were used for statistical analysis.
Results
Serum and salivary concentrations of estradiol were significantly higher in patients with breast cancer (BC) than in healthy women (P < .05). Also, serum CEA and salivary obestatin concentrations were significantly higher in BC patients than in the control group (P < .05). However, there was no significant difference between other parameters in patients with BC and controls. We observed a positive correlation between serum and salivary concentrations of CA15-3, as well as a negative correlation between serum and salivary concentrations of vaspin and obestatin.
Conclusion
The results of this study demonstrated that concentrations of CEA and estradiol in serum, obestatin in serum and saliva, and estradiol in saliva were significantly different between the 2 groups.</description><identifier>ISSN: 0007-5027</identifier><identifier>EISSN: 1943-7730</identifier><identifier>DOI: 10.1093/labmed/lmaa013</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Analysis ; Antigens ; Biological markers ; Biomarkers ; Breast cancer ; Cancer ; CEA (Oncology) ; Diagnosis ; Estradiol ; Health aspects ; Medical diagnosis ; Phenols ; Postmenopausal women ; Women</subject><ispartof>Laboratory medicine, 2020-11, Vol.51 (6), p.620-627</ispartof><rights>American Society for Clinical Pathology 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2020</rights><rights>COPYRIGHT 2020 Oxford University Press</rights><rights>American Society for Clinical Pathology 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c331t-cfddef120cb8f90acbfda10ecd93eed3eb72af39bcfddc4ae56229d90358d5433</citedby><cites>FETCH-LOGICAL-c331t-cfddef120cb8f90acbfda10ecd93eed3eb72af39bcfddc4ae56229d90358d5433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1579,27905,27906</link.rule.ids></links><search><creatorcontrib>Farahani, Hyder</creatorcontrib><creatorcontrib>Amri, Jamal</creatorcontrib><creatorcontrib>Alaee, Mona</creatorcontrib><creatorcontrib>Mohaghegh, Fathollah</creatorcontrib><creatorcontrib>Rafiee, Mohammad</creatorcontrib><title>Serum and Saliva Levels of Cancer Antigen 15-3, Carcinoembryonic Antigen, Estradiol, Vaspin, and Obestatin as Biomarkers for the Diagnosis of Breast Cancer in Postmenopausal Women</title><title>Laboratory medicine</title><description>Abstract
Objective
To find suitable biomarkers for diagnosis of Breast cancer in serum and saliva; also, to examine the correlation between salivary and serum concentrations of suitable biomarkers.
Methods
This case-control study included 30 women with breast cancer as a case group and 30 healthy women as a matched control group. Blood and saliva specimens were collected from all participants. We evaluated serum and salivary cancer antigen 15-3 (CA15-3), carcinoembryonic antigen (CEA), estradiol, vaspin, and obestatin concentrations. Mann-Whitney U testing and Spearman correlation coefficients were used for statistical analysis.
Results
Serum and salivary concentrations of estradiol were significantly higher in patients with breast cancer (BC) than in healthy women (P < .05). Also, serum CEA and salivary obestatin concentrations were significantly higher in BC patients than in the control group (P < .05). However, there was no significant difference between other parameters in patients with BC and controls. We observed a positive correlation between serum and salivary concentrations of CA15-3, as well as a negative correlation between serum and salivary concentrations of vaspin and obestatin.
Conclusion
The results of this study demonstrated that concentrations of CEA and estradiol in serum, obestatin in serum and saliva, and estradiol in saliva were significantly different between the 2 groups.</description><subject>Analysis</subject><subject>Antigens</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>CEA (Oncology)</subject><subject>Diagnosis</subject><subject>Estradiol</subject><subject>Health aspects</subject><subject>Medical diagnosis</subject><subject>Phenols</subject><subject>Postmenopausal women</subject><subject>Women</subject><issn>0007-5027</issn><issn>1943-7730</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkl1rFDEUhoMouK7eeh3wRmGnTSbzsbncrrUKCxXqx-VwJjlZUzPJmMwU-rv8g826LYIUJIFw3jzvOcnhEPKasxPOpDh10A-oT90AwLh4QhZcVqJoW8GekgVjrC1qVrbPyYuUrnNYyaZckN9XGOeBgtf0Cpy9AbrDG3SJBkO34BVGuvGT3aOnvC7EKotRWR9w6ONt8FY9XK_oeZoiaBvcin6DNNosHdJe9pgmmKynkOiZDQPEnxgTNSHS6QfS9xb2PiT7p-RZREjTQ-Xs-RzSNKAPI8wJHP0ecvCSPDPgEr66P5fk64fzL9uPxe7y4tN2syuUEHwqlNEaDS-Z6tdGMlC90cAZKi0FohbYtyUYIfsDqCrAuilLqSUT9VrXlRBL8vaYd4zh15x_0Q02KXQOPIY5dWXFhZStyHtJ3vyDXoc5-vy6TLUNb-p2vf5L7cFhZ70JuWPqkLTbNDJjFa9Ypk4eofLSOFgVPBqb9ccMKoaUIppujDa3-bbjrDuMRnccje5-NLLh3dEQ5vF_7B05Jr3u</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Farahani, Hyder</creator><creator>Amri, Jamal</creator><creator>Alaee, Mona</creator><creator>Mohaghegh, Fathollah</creator><creator>Rafiee, Mohammad</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20201101</creationdate><title>Serum and Saliva Levels of Cancer Antigen 15-3, Carcinoembryonic Antigen, Estradiol, Vaspin, and Obestatin as Biomarkers for the Diagnosis of Breast Cancer in Postmenopausal Women</title><author>Farahani, Hyder ; Amri, Jamal ; Alaee, Mona ; Mohaghegh, Fathollah ; Rafiee, Mohammad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-cfddef120cb8f90acbfda10ecd93eed3eb72af39bcfddc4ae56229d90358d5433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Analysis</topic><topic>Antigens</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>CEA (Oncology)</topic><topic>Diagnosis</topic><topic>Estradiol</topic><topic>Health aspects</topic><topic>Medical diagnosis</topic><topic>Phenols</topic><topic>Postmenopausal women</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farahani, Hyder</creatorcontrib><creatorcontrib>Amri, Jamal</creatorcontrib><creatorcontrib>Alaee, Mona</creatorcontrib><creatorcontrib>Mohaghegh, Fathollah</creatorcontrib><creatorcontrib>Rafiee, Mohammad</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farahani, Hyder</au><au>Amri, Jamal</au><au>Alaee, Mona</au><au>Mohaghegh, Fathollah</au><au>Rafiee, Mohammad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum and Saliva Levels of Cancer Antigen 15-3, Carcinoembryonic Antigen, Estradiol, Vaspin, and Obestatin as Biomarkers for the Diagnosis of Breast Cancer in Postmenopausal Women</atitle><jtitle>Laboratory medicine</jtitle><date>2020-11-01</date><risdate>2020</risdate><volume>51</volume><issue>6</issue><spage>620</spage><epage>627</epage><pages>620-627</pages><issn>0007-5027</issn><eissn>1943-7730</eissn><abstract>Abstract
Objective
To find suitable biomarkers for diagnosis of Breast cancer in serum and saliva; also, to examine the correlation between salivary and serum concentrations of suitable biomarkers.
Methods
This case-control study included 30 women with breast cancer as a case group and 30 healthy women as a matched control group. Blood and saliva specimens were collected from all participants. We evaluated serum and salivary cancer antigen 15-3 (CA15-3), carcinoembryonic antigen (CEA), estradiol, vaspin, and obestatin concentrations. Mann-Whitney U testing and Spearman correlation coefficients were used for statistical analysis.
Results
Serum and salivary concentrations of estradiol were significantly higher in patients with breast cancer (BC) than in healthy women (P < .05). Also, serum CEA and salivary obestatin concentrations were significantly higher in BC patients than in the control group (P < .05). However, there was no significant difference between other parameters in patients with BC and controls. We observed a positive correlation between serum and salivary concentrations of CA15-3, as well as a negative correlation between serum and salivary concentrations of vaspin and obestatin.
Conclusion
The results of this study demonstrated that concentrations of CEA and estradiol in serum, obestatin in serum and saliva, and estradiol in saliva were significantly different between the 2 groups.</abstract><cop>US</cop><pub>Oxford University Press</pub><doi>10.1093/labmed/lmaa013</doi><tpages>8</tpages></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Analysis Antigens Biological markers Biomarkers Breast cancer Cancer CEA (Oncology) Diagnosis Estradiol Health aspects Medical diagnosis Phenols Postmenopausal women Women |
| title | Serum and Saliva Levels of Cancer Antigen 15-3, Carcinoembryonic Antigen, Estradiol, Vaspin, and Obestatin as Biomarkers for the Diagnosis of Breast Cancer in Postmenopausal Women |
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