Human papillomavirus is more frequently detected in the pelvic than non-pelvic area in patients with squamous cell carcinoma in situ (Bowen’s disease)
Background The detection rate of human papillomavirus (HPV) in Bowen’s disease (BD) varies greatly. Objectives To detect HPV DNA in BD samples using next-generation sequencing (NGS) and compare HPV detection rates between pelvic and non-pelvic BD. Materials and Methods We evaluated 99 patients with...
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| Veröffentlicht in: | EJD. European journal of dermatology 2020-04, Vol.30 (2), p.111-118 |
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| creator | Baek, Yoo Sang Jeon, Jiehyun Kim, Aeree Song, Hae Jun Kim, Chungyeul |
| description | Background
The detection rate of human papillomavirus (HPV) in Bowen’s disease (BD) varies greatly.
Objectives
To detect HPV DNA in BD samples using next-generation sequencing (NGS) and compare HPV detection rates between pelvic and non-pelvic BD.
Materials and Methods
We evaluated 99 patients with BD in our institution. DNA was extracted from formalin-fixed and paraffin embedded (FFPE) tissue blocks. The presence of HPV DNA material was detected using special kit-based NGS technology. Clinical characteristics and HPV detection rates were then compared between pelvic and non-pelvic BD samples.
Results
HPV was detected in 26 (26.3%) BD samples. A total of 10 types of α-HPV was detected: HPV 16, 53, 31, 58, 66, 26, 27, 57, 45, and 72. The most common HPV type was 16 (12.1%). Only two types (27 and 57) were frequently classified as cutaneous type, and the rest were mucosal types. The HPV detection rate was significantly higher in pelvic BD (45.2%) compared to non-pelvic BD (17.6%).
Conclusion
The present study suggests that sexually transmitted mucosal α-HPV plays a significant role in the pathogenesis of BD, especially in the pelvic region. |
| doi_str_mv | 10.1684/ejd.2020.3700 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2413997149</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2413997149</sourcerecordid><originalsourceid>FETCH-LOGICAL-c332t-e2a8883d6f4eee6d9e8701d62877b8fe30f5d5ea5c96033eb24a0f323058622c3</originalsourceid><addsrcrecordid>eNp1kblOxDAQhi0E4i5pkUsosvjI4ZSAuCQkGqgtrz0BrxIn2A4rOh4DXo8nwdEudFQzI3_zz4x_hI4omdFS5GewMDNGGJnxipANtEvrgmU5oXwz5bSsMkoZ20F7ISxIwmouttEOZwUXvCh20eft2CmHBzXYtu079Wb9GLANuOs94MbD6wgutu_YQAQdwWDrcHwBPED7ZnVKU7frXbaulQc1IYOKNjUGvLTxBYfXUXV9EtbQtlgrr61LwyYw2Djik4t-Ce774ytgYwOoAKcHaKtRbYDDddxHT9dXj5e32f3Dzd3l-X2mOWcxA6aEENyUTQ4ApalBVISakomqmosGOGkKU4AqdF0SzmHOckUazjgpRMmY5vvoZKU7-D7dGqLsbJjWVA7SxpLllNd1RfM6odkK1b4PwUMjB2875d8lJXIyQyYz5GSGnMxI_PFaepx3YP7o399PwGwFhPTknsHLRT96l879R_EHl2-XzA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2413997149</pqid></control><display><type>article</type><title>Human papillomavirus is more frequently detected in the pelvic than non-pelvic area in patients with squamous cell carcinoma in situ (Bowen’s disease)</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Baek, Yoo Sang ; Jeon, Jiehyun ; Kim, Aeree ; Song, Hae Jun ; Kim, Chungyeul</creator><creatorcontrib>Baek, Yoo Sang ; Jeon, Jiehyun ; Kim, Aeree ; Song, Hae Jun ; Kim, Chungyeul</creatorcontrib><description>Background
The detection rate of human papillomavirus (HPV) in Bowen’s disease (BD) varies greatly.
Objectives
To detect HPV DNA in BD samples using next-generation sequencing (NGS) and compare HPV detection rates between pelvic and non-pelvic BD.
Materials and Methods
We evaluated 99 patients with BD in our institution. DNA was extracted from formalin-fixed and paraffin embedded (FFPE) tissue blocks. The presence of HPV DNA material was detected using special kit-based NGS technology. Clinical characteristics and HPV detection rates were then compared between pelvic and non-pelvic BD samples.
Results
HPV was detected in 26 (26.3%) BD samples. A total of 10 types of α-HPV was detected: HPV 16, 53, 31, 58, 66, 26, 27, 57, 45, and 72. The most common HPV type was 16 (12.1%). Only two types (27 and 57) were frequently classified as cutaneous type, and the rest were mucosal types. The HPV detection rate was significantly higher in pelvic BD (45.2%) compared to non-pelvic BD (17.6%).
Conclusion
The present study suggests that sexually transmitted mucosal α-HPV plays a significant role in the pathogenesis of BD, especially in the pelvic region.</description><identifier>ISSN: 1167-1122</identifier><identifier>EISSN: 1952-4013</identifier><identifier>DOI: 10.1684/ejd.2020.3700</identifier><identifier>PMID: 32538355</identifier><language>eng</language><publisher>Paris: John Libbey Eurotext</publisher><subject>Abdominal Wall - pathology ; Abdominal Wall - virology ; Aged ; Aged, 80 and over ; Alphapapillomavirus - genetics ; Alphapapillomavirus - isolation & purification ; Biopsy ; Bowen's Disease - etiology ; Bowen's Disease - virology ; Buttocks ; Dermatology ; DNA, Viral - genetics ; DNA, Viral - isolation & purification ; Female ; Genotype ; Genotyping Techniques ; Groin - pathology ; Groin - virology ; High-Throughput Nucleotide Sequencing ; Human papillomavirus 16 - genetics ; Human papillomavirus 16 - isolation & purification ; Humans ; Investigative Report ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Mucous Membrane - pathology ; Mucous Membrane - virology ; Papillomavirus Infections - complications ; Papillomavirus Infections - genetics ; Papillomavirus Infections - virology ; Retrospective Studies ; Sexually Transmitted Diseases, Viral - complications ; Sexually Transmitted Diseases, Viral - virology ; Skin - pathology ; Skin - virology ; Thigh - pathology ; Thigh - virology</subject><ispartof>EJD. European journal of dermatology, 2020-04, Vol.30 (2), p.111-118</ispartof><rights>JLE/Springer 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-e2a8883d6f4eee6d9e8701d62877b8fe30f5d5ea5c96033eb24a0f323058622c3</citedby><cites>FETCH-LOGICAL-c332t-e2a8883d6f4eee6d9e8701d62877b8fe30f5d5ea5c96033eb24a0f323058622c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1684/ejd.2020.3700$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1684/ejd.2020.3700$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32538355$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baek, Yoo Sang</creatorcontrib><creatorcontrib>Jeon, Jiehyun</creatorcontrib><creatorcontrib>Kim, Aeree</creatorcontrib><creatorcontrib>Song, Hae Jun</creatorcontrib><creatorcontrib>Kim, Chungyeul</creatorcontrib><title>Human papillomavirus is more frequently detected in the pelvic than non-pelvic area in patients with squamous cell carcinoma in situ (Bowen’s disease)</title><title>EJD. European journal of dermatology</title><addtitle>Eur J Dermatol</addtitle><addtitle>Eur J Dermatol</addtitle><description>Background
The detection rate of human papillomavirus (HPV) in Bowen’s disease (BD) varies greatly.
Objectives
To detect HPV DNA in BD samples using next-generation sequencing (NGS) and compare HPV detection rates between pelvic and non-pelvic BD.
Materials and Methods
We evaluated 99 patients with BD in our institution. DNA was extracted from formalin-fixed and paraffin embedded (FFPE) tissue blocks. The presence of HPV DNA material was detected using special kit-based NGS technology. Clinical characteristics and HPV detection rates were then compared between pelvic and non-pelvic BD samples.
Results
HPV was detected in 26 (26.3%) BD samples. A total of 10 types of α-HPV was detected: HPV 16, 53, 31, 58, 66, 26, 27, 57, 45, and 72. The most common HPV type was 16 (12.1%). Only two types (27 and 57) were frequently classified as cutaneous type, and the rest were mucosal types. The HPV detection rate was significantly higher in pelvic BD (45.2%) compared to non-pelvic BD (17.6%).
Conclusion
The present study suggests that sexually transmitted mucosal α-HPV plays a significant role in the pathogenesis of BD, especially in the pelvic region.</description><subject>Abdominal Wall - pathology</subject><subject>Abdominal Wall - virology</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alphapapillomavirus - genetics</subject><subject>Alphapapillomavirus - isolation & purification</subject><subject>Biopsy</subject><subject>Bowen's Disease - etiology</subject><subject>Bowen's Disease - virology</subject><subject>Buttocks</subject><subject>Dermatology</subject><subject>DNA, Viral - genetics</subject><subject>DNA, Viral - isolation & purification</subject><subject>Female</subject><subject>Genotype</subject><subject>Genotyping Techniques</subject><subject>Groin - pathology</subject><subject>Groin - virology</subject><subject>High-Throughput Nucleotide Sequencing</subject><subject>Human papillomavirus 16 - genetics</subject><subject>Human papillomavirus 16 - isolation & purification</subject><subject>Humans</subject><subject>Investigative Report</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mucous Membrane - pathology</subject><subject>Mucous Membrane - virology</subject><subject>Papillomavirus Infections - complications</subject><subject>Papillomavirus Infections - genetics</subject><subject>Papillomavirus Infections - virology</subject><subject>Retrospective Studies</subject><subject>Sexually Transmitted Diseases, Viral - complications</subject><subject>Sexually Transmitted Diseases, Viral - virology</subject><subject>Skin - pathology</subject><subject>Skin - virology</subject><subject>Thigh - pathology</subject><subject>Thigh - virology</subject><issn>1167-1122</issn><issn>1952-4013</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kblOxDAQhi0E4i5pkUsosvjI4ZSAuCQkGqgtrz0BrxIn2A4rOh4DXo8nwdEudFQzI3_zz4x_hI4omdFS5GewMDNGGJnxipANtEvrgmU5oXwz5bSsMkoZ20F7ISxIwmouttEOZwUXvCh20eft2CmHBzXYtu079Wb9GLANuOs94MbD6wgutu_YQAQdwWDrcHwBPED7ZnVKU7frXbaulQc1IYOKNjUGvLTxBYfXUXV9EtbQtlgrr61LwyYw2Djik4t-Ce774ytgYwOoAKcHaKtRbYDDddxHT9dXj5e32f3Dzd3l-X2mOWcxA6aEENyUTQ4ApalBVISakomqmosGOGkKU4AqdF0SzmHOckUazjgpRMmY5vvoZKU7-D7dGqLsbJjWVA7SxpLllNd1RfM6odkK1b4PwUMjB2875d8lJXIyQyYz5GSGnMxI_PFaepx3YP7o399PwGwFhPTknsHLRT96l879R_EHl2-XzA</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Baek, Yoo Sang</creator><creator>Jeon, Jiehyun</creator><creator>Kim, Aeree</creator><creator>Song, Hae Jun</creator><creator>Kim, Chungyeul</creator><general>John Libbey Eurotext</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200401</creationdate><title>Human papillomavirus is more frequently detected in the pelvic than non-pelvic area in patients with squamous cell carcinoma in situ (Bowen’s disease)</title><author>Baek, Yoo Sang ; Jeon, Jiehyun ; Kim, Aeree ; Song, Hae Jun ; Kim, Chungyeul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-e2a8883d6f4eee6d9e8701d62877b8fe30f5d5ea5c96033eb24a0f323058622c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abdominal Wall - pathology</topic><topic>Abdominal Wall - virology</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alphapapillomavirus - genetics</topic><topic>Alphapapillomavirus - isolation & purification</topic><topic>Biopsy</topic><topic>Bowen's Disease - etiology</topic><topic>Bowen's Disease - virology</topic><topic>Buttocks</topic><topic>Dermatology</topic><topic>DNA, Viral - genetics</topic><topic>DNA, Viral - isolation & purification</topic><topic>Female</topic><topic>Genotype</topic><topic>Genotyping Techniques</topic><topic>Groin - pathology</topic><topic>Groin - virology</topic><topic>High-Throughput Nucleotide Sequencing</topic><topic>Human papillomavirus 16 - genetics</topic><topic>Human papillomavirus 16 - isolation & purification</topic><topic>Humans</topic><topic>Investigative Report</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mucous Membrane - pathology</topic><topic>Mucous Membrane - virology</topic><topic>Papillomavirus Infections - complications</topic><topic>Papillomavirus Infections - genetics</topic><topic>Papillomavirus Infections - virology</topic><topic>Retrospective Studies</topic><topic>Sexually Transmitted Diseases, Viral - complications</topic><topic>Sexually Transmitted Diseases, Viral - virology</topic><topic>Skin - pathology</topic><topic>Skin - virology</topic><topic>Thigh - pathology</topic><topic>Thigh - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baek, Yoo Sang</creatorcontrib><creatorcontrib>Jeon, Jiehyun</creatorcontrib><creatorcontrib>Kim, Aeree</creatorcontrib><creatorcontrib>Song, Hae Jun</creatorcontrib><creatorcontrib>Kim, Chungyeul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>EJD. European journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baek, Yoo Sang</au><au>Jeon, Jiehyun</au><au>Kim, Aeree</au><au>Song, Hae Jun</au><au>Kim, Chungyeul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human papillomavirus is more frequently detected in the pelvic than non-pelvic area in patients with squamous cell carcinoma in situ (Bowen’s disease)</atitle><jtitle>EJD. European journal of dermatology</jtitle><stitle>Eur J Dermatol</stitle><addtitle>Eur J Dermatol</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>30</volume><issue>2</issue><spage>111</spage><epage>118</epage><pages>111-118</pages><issn>1167-1122</issn><eissn>1952-4013</eissn><abstract>Background
The detection rate of human papillomavirus (HPV) in Bowen’s disease (BD) varies greatly.
Objectives
To detect HPV DNA in BD samples using next-generation sequencing (NGS) and compare HPV detection rates between pelvic and non-pelvic BD.
Materials and Methods
We evaluated 99 patients with BD in our institution. DNA was extracted from formalin-fixed and paraffin embedded (FFPE) tissue blocks. The presence of HPV DNA material was detected using special kit-based NGS technology. Clinical characteristics and HPV detection rates were then compared between pelvic and non-pelvic BD samples.
Results
HPV was detected in 26 (26.3%) BD samples. A total of 10 types of α-HPV was detected: HPV 16, 53, 31, 58, 66, 26, 27, 57, 45, and 72. The most common HPV type was 16 (12.1%). Only two types (27 and 57) were frequently classified as cutaneous type, and the rest were mucosal types. The HPV detection rate was significantly higher in pelvic BD (45.2%) compared to non-pelvic BD (17.6%).
Conclusion
The present study suggests that sexually transmitted mucosal α-HPV plays a significant role in the pathogenesis of BD, especially in the pelvic region.</abstract><cop>Paris</cop><pub>John Libbey Eurotext</pub><pmid>32538355</pmid><doi>10.1684/ejd.2020.3700</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 1167-1122 |
| ispartof | EJD. European journal of dermatology, 2020-04, Vol.30 (2), p.111-118 |
| issn | 1167-1122 1952-4013 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Abdominal Wall - pathology Abdominal Wall - virology Aged Aged, 80 and over Alphapapillomavirus - genetics Alphapapillomavirus - isolation & purification Biopsy Bowen's Disease - etiology Bowen's Disease - virology Buttocks Dermatology DNA, Viral - genetics DNA, Viral - isolation & purification Female Genotype Genotyping Techniques Groin - pathology Groin - virology High-Throughput Nucleotide Sequencing Human papillomavirus 16 - genetics Human papillomavirus 16 - isolation & purification Humans Investigative Report Male Medicine Medicine & Public Health Middle Aged Mucous Membrane - pathology Mucous Membrane - virology Papillomavirus Infections - complications Papillomavirus Infections - genetics Papillomavirus Infections - virology Retrospective Studies Sexually Transmitted Diseases, Viral - complications Sexually Transmitted Diseases, Viral - virology Skin - pathology Skin - virology Thigh - pathology Thigh - virology |
| title | Human papillomavirus is more frequently detected in the pelvic than non-pelvic area in patients with squamous cell carcinoma in situ (Bowen’s disease) |
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