Protein arginine methyltransferase-1 stimulates dopaminergic neuronal cell death in a Parkinson’s disease model

Recent studies have revealed that protein arginine methyltransferases (PRMTs) are responsible for diverse neurodegenerative diseases. However, their pathophysiological role in dopaminergic neuronal death in Parkinson’s disease (PD) has not been evaluated. In this study, we demonstrated that 1-Methyl...

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Veröffentlicht in:	Biochemical and biophysical research communications 2020-09, Vol.530 (2), p.389-395
Hauptverfasser:	Nho, Jong-Hyun, Park, Min-Jung, Park, Hyung Joon, Lee, Jin Ho, Choi, Joo-Hee, Oh, Sang-Jin, Lee, Young-Jin, Yu, Young-Beob, Kim, Hyung-Seok, Kim, Dong-il, Choi, Won-Seok
Format:	Artikel
Sprache:	eng
Schlagworte:	AIF Animals Cell Death Disease Models, Animal Dopaminergic neuronal death Dopaminergic Neurons - metabolism Dopaminergic Neurons - pathology Humans Male Mice Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson’s disease PARP1 Parthanatos PRMT1 Protein-Arginine N-Methyltransferases - analysis Protein-Arginine N-Methyltransferases - metabolism
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