RETRACTED: Optimized Conjugation of Fluvastatin to HIV-1 TAT Displays Enhanced Pro-Apoptotic Activity in HepG2 Cells

Accumulating evidence indicates that statins reduce the risk of different cancers and inhibit the proliferation of liver cancer cells. This study aims to explore whether the electrostatic conjugation of optimized fluvastatin (FLV) to human immunodeficiency virus type 1 (HIV-1) trans-activator transc...

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Veröffentlicht in:	International journal of molecular sciences 2020-06, Vol.21 (11), p.4138
Hauptverfasser:	Al-Wahaibi, Lamya H, Al-Saleem, Muneera S M, Ahmed, Osama A A, Fahmy, Usama A, Alhakamy, Nabil A, Eid, Basma G, Abdel-Naim, Ashraf B, Abdel-Mageed, Wael M, AlRasheed, Maha M, Shazly, Gamal A
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Annexin V Apoptosis Apoptosis - drug effects Caspase 3 - metabolism Caspase-3 Cell cycle Cell death Cell proliferation Cell Proliferation - drug effects Cholesterol Conjugation Cytotoxicity Design factors Drug Compounding Factorial design Flow Cytometry Fluvastatin Fluvastatin - chemistry Fluvastatin - pharmacology G phase Hep G2 Cells Hepatocytes Humans Investigations Liver cancer Metabolism Particle Size Peptides Spectroscopy, Fourier Transform Infrared Statins tat Gene Products, Human Immunodeficiency Virus - chemistry Tat protein Transcription Variance analysis Zeta potential
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