Evolution of a splice variant that acts as an endogenous antagonist of the original INSL3 in primates

•Human Alu-INSL3 might be on its way to functionality and has potential to antagonize LGR8-INSL3 function.•Provide an example of the evolutionary trajectory of a variant peptide hormone antagonist that caused by the insertion of an Alu element in primates.•A new exon in the INSL3 gene, which evolved...

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Veröffentlicht in:	Gene 2020-09, Vol.754, p.144861-144861, Article 144861
Hauptverfasser:	Yang, Na, Chen, Haidi, Hu, Minghui, Zhang, Geyu, Amanullah, Deng, Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Alu element Antagonist Exonization Peptide hormone Primate
Online-Zugang:	Volltext
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