Ultra-stable Biomembrane Force Probe for Accurately Determining Slow Dissociation Kinetics of PD‑1 Blockade Antibodies on Single Living Cells

Immune checkpoint blockade with monoclonal antibodies (mAbs) that target programmed cell death protein-1 (PD-1) has remarkably revolutionized cancer therapy. Their binding kinetics measured by surface plasmon resonance does not always correlate well with their immunotherapeutic efficacies, mainly du...

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Veröffentlicht in:	Nano letters 2020-07, Vol.20 (7), p.5133-5140
Hauptverfasser:	An, Chenyi, Hu, Wei, Gao, Jie, Ju, Bing-Feng, Obeidy, Peyman, Zhao, Yunduo Charles, Tu, Xiaoxuan, Fang, Weijia, Ju, Lining Arnold, Chen, Wei
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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