The role of immune and oxidative pathways in menstrual cycle associated depressive, physio-somatic, breast and anxiety symptoms: Modulation by sex hormones
To examine whether 1) immune and nitro-oxidative stress (IO&NS) biomarkers are associated with premenstrual syndrome (PMS); and 2) changes in IO&NS biomarkers during the menstrual cycle (MC) are associated with PMS symptoms and plasma estradiol and progesterone. This longitudinal study exami...
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| Veröffentlicht in: | Journal of psychosomatic research 2020-08, Vol.135, p.110158-110158, Article 110158 |
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| creator | Roomruangwong, Chutima Matsumoto, Andressa Keiko Michelin, Ana Paula de Oliveira Semeão, Laura de Lima Pedrão, João Victor Moreira, Estefania G. Sirivichayakul, Sunee Carvalho, Andre Barbosa, Decio S. Maes, Michael |
| description | To examine whether 1) immune and nitro-oxidative stress (IO&NS) biomarkers are associated with premenstrual syndrome (PMS); and 2) changes in IO&NS biomarkers during the menstrual cycle (MC) are associated with PMS symptoms and plasma estradiol and progesterone.
This longitudinal study examined 41 women who completed the Daily Record of Severity of Problems (DRSP) rating scale during 28 consecutive days and assayed plasma levels of complement C3 and C4, highly sensitive C-reactive protein (hsCRP), haptoglobin (Hp), advanced oxidation protein products (AOPP), lipid hydroperoxides (LOOH), nitric oxide metabolites (NOx), total radical-trapping antioxidant parameter (TRAP), sulfhydryl (-SH) groups and the activity of paraoxonase (PON)1 at days 7 (D7), 14 (D14), 21 (D21) and 28 (D28) of the MC. MC Associated Syndrome (MCAS) was diagnosed when the summed DRSP score during the MC is >0.666 percentile.
All biomarkers, except hsCRP, showed significant alterations during the MC. Arylesterase (AREase) was lowered at D28, while LOOH increased at D14 and C4 at D21 in MCAS. Total DRSP scores were predicted by the combined effects of C4 (positively) and AREase and malondialdehyde (MDA) (both inversely associated). Progesterone lowered levels of LOOH, AOPP and C3 and estradiol lowered levels of Hp while both sex hormones increased 4-(chloromethyl)phenyl acetate (CMPA)ase and AREase activities and levels of -SH groups.
PMS/MCAS is not accompanied by a peripheral inflammatory response. Lowered MDA and antioxidant defenses and increased C4 may play a role in MC symptoms while sex hormones may have a protective effect against oxidative stress toxicity.
•The menstrual cycle is accompanied by changes in nitro-oxidative biomarkers.•Menstrual cycle associated symptoms (MCAS) are associated with oxidative biomarkers.•Malondialdehyde and paraoxonase 1 are inversely associated with MCAS.•MCAS symptoms are positively associated with complement C4.•Sex hormones have a protective effect against oxidative stress toxicity. |
| doi_str_mv | 10.1016/j.jpsychores.2020.110158 |
| format | Article |
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This longitudinal study examined 41 women who completed the Daily Record of Severity of Problems (DRSP) rating scale during 28 consecutive days and assayed plasma levels of complement C3 and C4, highly sensitive C-reactive protein (hsCRP), haptoglobin (Hp), advanced oxidation protein products (AOPP), lipid hydroperoxides (LOOH), nitric oxide metabolites (NOx), total radical-trapping antioxidant parameter (TRAP), sulfhydryl (-SH) groups and the activity of paraoxonase (PON)1 at days 7 (D7), 14 (D14), 21 (D21) and 28 (D28) of the MC. MC Associated Syndrome (MCAS) was diagnosed when the summed DRSP score during the MC is >0.666 percentile.
All biomarkers, except hsCRP, showed significant alterations during the MC. Arylesterase (AREase) was lowered at D28, while LOOH increased at D14 and C4 at D21 in MCAS. Total DRSP scores were predicted by the combined effects of C4 (positively) and AREase and malondialdehyde (MDA) (both inversely associated). Progesterone lowered levels of LOOH, AOPP and C3 and estradiol lowered levels of Hp while both sex hormones increased 4-(chloromethyl)phenyl acetate (CMPA)ase and AREase activities and levels of -SH groups.
PMS/MCAS is not accompanied by a peripheral inflammatory response. Lowered MDA and antioxidant defenses and increased C4 may play a role in MC symptoms while sex hormones may have a protective effect against oxidative stress toxicity.
•The menstrual cycle is accompanied by changes in nitro-oxidative biomarkers.•Menstrual cycle associated symptoms (MCAS) are associated with oxidative biomarkers.•Malondialdehyde and paraoxonase 1 are inversely associated with MCAS.•MCAS symptoms are positively associated with complement C4.•Sex hormones have a protective effect against oxidative stress toxicity.</description><identifier>ISSN: 0022-3999</identifier><identifier>EISSN: 1879-1360</identifier><identifier>DOI: 10.1016/j.jpsychores.2020.110158</identifier><identifier>PMID: 32526539</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>17β-Estradiol ; Acetic acid ; Adult ; Antioxidants ; Anxiety ; Anxiety - complications ; Anxiety - metabolism ; Anxiety - physiopathology ; Arylesterase ; Biological markers ; Biomarkers ; Biomarkers - blood ; Breast ; Breast - pathology ; C-reactive protein ; C-Reactive Protein - metabolism ; Complement component C3 ; Complement component C4 ; Depression ; Female ; Gonadal Steroid Hormones - metabolism ; Haptoglobin ; Hormones ; Humans ; Inflammation ; Lipid peroxidation ; Longitudinal Studies ; Malondialdehyde ; Menstrual cycle ; Menstrual Cycle - metabolism ; Menstrual Cycle - physiology ; Menstrual Cycle - psychology ; Menstruation ; Mental depression ; Metabolites ; Middle Aged ; Neuro-immune ; Nitric oxide ; Nitric Oxide - blood ; Oxidative Stress ; Paraoxonase ; Plasma levels ; PMS ; Premenstrual syndrome ; Progesterone ; Sex hormones ; Somatic symptoms ; Toxicity ; Women</subject><ispartof>Journal of psychosomatic research, 2020-08, Vol.135, p.110158-110158, Article 110158</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Aug 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-7fc81424aac19378d4ad861e2927764fa92dcd7df9de4d1193c1aacd3432ca703</citedby><cites>FETCH-LOGICAL-c402t-7fc81424aac19378d4ad861e2927764fa92dcd7df9de4d1193c1aacd3432ca703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022399920301690$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,30976,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32526539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roomruangwong, Chutima</creatorcontrib><creatorcontrib>Matsumoto, Andressa Keiko</creatorcontrib><creatorcontrib>Michelin, Ana Paula</creatorcontrib><creatorcontrib>de Oliveira Semeão, Laura</creatorcontrib><creatorcontrib>de Lima Pedrão, João Victor</creatorcontrib><creatorcontrib>Moreira, Estefania G.</creatorcontrib><creatorcontrib>Sirivichayakul, Sunee</creatorcontrib><creatorcontrib>Carvalho, Andre</creatorcontrib><creatorcontrib>Barbosa, Decio S.</creatorcontrib><creatorcontrib>Maes, Michael</creatorcontrib><title>The role of immune and oxidative pathways in menstrual cycle associated depressive, physio-somatic, breast and anxiety symptoms: Modulation by sex hormones</title><title>Journal of psychosomatic research</title><addtitle>J Psychosom Res</addtitle><description>To examine whether 1) immune and nitro-oxidative stress (IO&NS) biomarkers are associated with premenstrual syndrome (PMS); and 2) changes in IO&NS biomarkers during the menstrual cycle (MC) are associated with PMS symptoms and plasma estradiol and progesterone.
This longitudinal study examined 41 women who completed the Daily Record of Severity of Problems (DRSP) rating scale during 28 consecutive days and assayed plasma levels of complement C3 and C4, highly sensitive C-reactive protein (hsCRP), haptoglobin (Hp), advanced oxidation protein products (AOPP), lipid hydroperoxides (LOOH), nitric oxide metabolites (NOx), total radical-trapping antioxidant parameter (TRAP), sulfhydryl (-SH) groups and the activity of paraoxonase (PON)1 at days 7 (D7), 14 (D14), 21 (D21) and 28 (D28) of the MC. MC Associated Syndrome (MCAS) was diagnosed when the summed DRSP score during the MC is >0.666 percentile.
All biomarkers, except hsCRP, showed significant alterations during the MC. Arylesterase (AREase) was lowered at D28, while LOOH increased at D14 and C4 at D21 in MCAS. Total DRSP scores were predicted by the combined effects of C4 (positively) and AREase and malondialdehyde (MDA) (both inversely associated). Progesterone lowered levels of LOOH, AOPP and C3 and estradiol lowered levels of Hp while both sex hormones increased 4-(chloromethyl)phenyl acetate (CMPA)ase and AREase activities and levels of -SH groups.
PMS/MCAS is not accompanied by a peripheral inflammatory response. Lowered MDA and antioxidant defenses and increased C4 may play a role in MC symptoms while sex hormones may have a protective effect against oxidative stress toxicity.
•The menstrual cycle is accompanied by changes in nitro-oxidative biomarkers.•Menstrual cycle associated symptoms (MCAS) are associated with oxidative biomarkers.•Malondialdehyde and paraoxonase 1 are inversely associated with MCAS.•MCAS symptoms are positively associated with complement C4.•Sex hormones have a protective effect against oxidative stress toxicity.</description><subject>17β-Estradiol</subject><subject>Acetic acid</subject><subject>Adult</subject><subject>Antioxidants</subject><subject>Anxiety</subject><subject>Anxiety - complications</subject><subject>Anxiety - metabolism</subject><subject>Anxiety - physiopathology</subject><subject>Arylesterase</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Breast</subject><subject>Breast - pathology</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Complement component C3</subject><subject>Complement component C4</subject><subject>Depression</subject><subject>Female</subject><subject>Gonadal Steroid Hormones - metabolism</subject><subject>Haptoglobin</subject><subject>Hormones</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Lipid peroxidation</subject><subject>Longitudinal Studies</subject><subject>Malondialdehyde</subject><subject>Menstrual cycle</subject><subject>Menstrual Cycle - metabolism</subject><subject>Menstrual Cycle - physiology</subject><subject>Menstrual Cycle - psychology</subject><subject>Menstruation</subject><subject>Mental depression</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Neuro-immune</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - blood</subject><subject>Oxidative Stress</subject><subject>Paraoxonase</subject><subject>Plasma levels</subject><subject>PMS</subject><subject>Premenstrual syndrome</subject><subject>Progesterone</subject><subject>Sex hormones</subject><subject>Somatic symptoms</subject><subject>Toxicity</subject><subject>Women</subject><issn>0022-3999</issn><issn>1879-1360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqFkc2O1DAQhCMEYoeFV0CWuHDYDLbjSWJusOJPWsRlOVseu6NxFNvB7SyTZ-Fl8TALSFw4WSp9Vd3tqirC6JZR1r4at-OMqznEBLjllBe56Lv-QbVhfSdr1rT0YbWhlPO6kVJeVE8QR0ppK_nucXXR8B1vd43cVD9uD0BSnIDEgTjvlwBEB0vi0Vmd3R2QWefDd70icYF4CJjToidiVlM8GjEapzNYYmEuy2BxXJH5sKKLNUZfIswV2SfQmH_l6nB0kFeCq59z9PiafI52mQoXA9kXHY6knOVjAHxaPRr0hPDs_r2svr5_d3v9sb758uHT9Zub2gjKc90NpmeCC60Nk03XW6Ft3zLgknddKwYtuTW2s4O0ICwrjGGFtY1ouNEdbS6rl-fcOcVvC2BW3qGBadIB4oKKC8alZIL2BX3xDzrGJYWyXaGEkJLz9hTYnymTImKCQc3JeZ1Wxag6FahG9bdAdSpQnQss1uf3A5a9B_vH-LuxArw9A1B-5M5BUmgcBAPWJTBZ2ej-P-UnDy-1KA</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>Roomruangwong, Chutima</creator><creator>Matsumoto, Andressa Keiko</creator><creator>Michelin, Ana Paula</creator><creator>de Oliveira Semeão, Laura</creator><creator>de Lima Pedrão, João Victor</creator><creator>Moreira, Estefania G.</creator><creator>Sirivichayakul, Sunee</creator><creator>Carvalho, Andre</creator><creator>Barbosa, Decio S.</creator><creator>Maes, Michael</creator><general>Elsevier Inc</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>202008</creationdate><title>The role of immune and oxidative pathways in menstrual cycle associated depressive, physio-somatic, breast and anxiety symptoms: Modulation by sex hormones</title><author>Roomruangwong, Chutima ; Matsumoto, Andressa Keiko ; Michelin, Ana Paula ; de Oliveira Semeão, Laura ; de Lima Pedrão, João Victor ; Moreira, Estefania G. ; Sirivichayakul, Sunee ; Carvalho, Andre ; Barbosa, Decio S. ; Maes, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-7fc81424aac19378d4ad861e2927764fa92dcd7df9de4d1193c1aacd3432ca703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>17β-Estradiol</topic><topic>Acetic acid</topic><topic>Adult</topic><topic>Antioxidants</topic><topic>Anxiety</topic><topic>Anxiety - complications</topic><topic>Anxiety - metabolism</topic><topic>Anxiety - physiopathology</topic><topic>Arylesterase</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Breast</topic><topic>Breast - pathology</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Complement component C3</topic><topic>Complement component C4</topic><topic>Depression</topic><topic>Female</topic><topic>Gonadal Steroid Hormones - metabolism</topic><topic>Haptoglobin</topic><topic>Hormones</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Lipid peroxidation</topic><topic>Longitudinal Studies</topic><topic>Malondialdehyde</topic><topic>Menstrual cycle</topic><topic>Menstrual Cycle - metabolism</topic><topic>Menstrual Cycle - physiology</topic><topic>Menstrual Cycle - psychology</topic><topic>Menstruation</topic><topic>Mental depression</topic><topic>Metabolites</topic><topic>Middle Aged</topic><topic>Neuro-immune</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - blood</topic><topic>Oxidative Stress</topic><topic>Paraoxonase</topic><topic>Plasma levels</topic><topic>PMS</topic><topic>Premenstrual syndrome</topic><topic>Progesterone</topic><topic>Sex hormones</topic><topic>Somatic symptoms</topic><topic>Toxicity</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roomruangwong, Chutima</creatorcontrib><creatorcontrib>Matsumoto, Andressa Keiko</creatorcontrib><creatorcontrib>Michelin, Ana Paula</creatorcontrib><creatorcontrib>de Oliveira Semeão, Laura</creatorcontrib><creatorcontrib>de Lima Pedrão, João Victor</creatorcontrib><creatorcontrib>Moreira, Estefania G.</creatorcontrib><creatorcontrib>Sirivichayakul, Sunee</creatorcontrib><creatorcontrib>Carvalho, Andre</creatorcontrib><creatorcontrib>Barbosa, Decio S.</creatorcontrib><creatorcontrib>Maes, Michael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of psychosomatic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roomruangwong, Chutima</au><au>Matsumoto, Andressa Keiko</au><au>Michelin, Ana Paula</au><au>de Oliveira Semeão, Laura</au><au>de Lima Pedrão, João Victor</au><au>Moreira, Estefania G.</au><au>Sirivichayakul, Sunee</au><au>Carvalho, Andre</au><au>Barbosa, Decio S.</au><au>Maes, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of immune and oxidative pathways in menstrual cycle associated depressive, physio-somatic, breast and anxiety symptoms: Modulation by sex hormones</atitle><jtitle>Journal of psychosomatic research</jtitle><addtitle>J Psychosom Res</addtitle><date>2020-08</date><risdate>2020</risdate><volume>135</volume><spage>110158</spage><epage>110158</epage><pages>110158-110158</pages><artnum>110158</artnum><issn>0022-3999</issn><eissn>1879-1360</eissn><abstract>To examine whether 1) immune and nitro-oxidative stress (IO&NS) biomarkers are associated with premenstrual syndrome (PMS); and 2) changes in IO&NS biomarkers during the menstrual cycle (MC) are associated with PMS symptoms and plasma estradiol and progesterone.
This longitudinal study examined 41 women who completed the Daily Record of Severity of Problems (DRSP) rating scale during 28 consecutive days and assayed plasma levels of complement C3 and C4, highly sensitive C-reactive protein (hsCRP), haptoglobin (Hp), advanced oxidation protein products (AOPP), lipid hydroperoxides (LOOH), nitric oxide metabolites (NOx), total radical-trapping antioxidant parameter (TRAP), sulfhydryl (-SH) groups and the activity of paraoxonase (PON)1 at days 7 (D7), 14 (D14), 21 (D21) and 28 (D28) of the MC. MC Associated Syndrome (MCAS) was diagnosed when the summed DRSP score during the MC is >0.666 percentile.
All biomarkers, except hsCRP, showed significant alterations during the MC. Arylesterase (AREase) was lowered at D28, while LOOH increased at D14 and C4 at D21 in MCAS. Total DRSP scores were predicted by the combined effects of C4 (positively) and AREase and malondialdehyde (MDA) (both inversely associated). Progesterone lowered levels of LOOH, AOPP and C3 and estradiol lowered levels of Hp while both sex hormones increased 4-(chloromethyl)phenyl acetate (CMPA)ase and AREase activities and levels of -SH groups.
PMS/MCAS is not accompanied by a peripheral inflammatory response. Lowered MDA and antioxidant defenses and increased C4 may play a role in MC symptoms while sex hormones may have a protective effect against oxidative stress toxicity.
•The menstrual cycle is accompanied by changes in nitro-oxidative biomarkers.•Menstrual cycle associated symptoms (MCAS) are associated with oxidative biomarkers.•Malondialdehyde and paraoxonase 1 are inversely associated with MCAS.•MCAS symptoms are positively associated with complement C4.•Sex hormones have a protective effect against oxidative stress toxicity.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>32526539</pmid><doi>10.1016/j.jpsychores.2020.110158</doi><tpages>1</tpages></addata></record> |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 17β-Estradiol Acetic acid Adult Antioxidants Anxiety Anxiety - complications Anxiety - metabolism Anxiety - physiopathology Arylesterase Biological markers Biomarkers Biomarkers - blood Breast Breast - pathology C-reactive protein C-Reactive Protein - metabolism Complement component C3 Complement component C4 Depression Female Gonadal Steroid Hormones - metabolism Haptoglobin Hormones Humans Inflammation Lipid peroxidation Longitudinal Studies Malondialdehyde Menstrual cycle Menstrual Cycle - metabolism Menstrual Cycle - physiology Menstrual Cycle - psychology Menstruation Mental depression Metabolites Middle Aged Neuro-immune Nitric oxide Nitric Oxide - blood Oxidative Stress Paraoxonase Plasma levels PMS Premenstrual syndrome Progesterone Sex hormones Somatic symptoms Toxicity Women |
| title | The role of immune and oxidative pathways in menstrual cycle associated depressive, physio-somatic, breast and anxiety symptoms: Modulation by sex hormones |
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