Urinary values of NT-proBNP in children with congenital heart disease – Is it feasible?
•NT-ProBNP can be determined in urine of children with congenital heart disease.•Spot-urine corrected to urine-creatinine can be used as an alternative to plasma samples.•Blood sampling can be reduced in traumatized children with congenital heart disease. Plasma NT-proBNP (N-terminal prohormone of b...
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| Veröffentlicht in: | Clinica chimica acta 2020-10, Vol.509, p.224-227 |
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| creator | Müller, Nicole Rothkegel, Stefanie T. Boerter, Nicolas Breuer, Johannes Freudenthal, Noa J. |
| description | •NT-ProBNP can be determined in urine of children with congenital heart disease.•Spot-urine corrected to urine-creatinine can be used as an alternative to plasma samples.•Blood sampling can be reduced in traumatized children with congenital heart disease.
Plasma NT-proBNP (N-terminal prohormone of brain natriuretic peptide) is an established clinical biomarker for children with congenital heart disease. In adult studies the relation between plasma and urinary NT-proBNP has been investigated with a good correlation. Considering the age dependence of NT-proBNP in healthy children and the age dependence of kidney function, an investigation of the correlation between NT-proBNP plasma and urinary values in children of different ages is necessary. We analyzed plasma and urine samples of 33 children (mean age 7 months) with congenital heart disease before surgery. Plasma and urinary creatinine were also measured to evaluate the influence of kidney function. A Pearson correlation between Lg10-plasma and Lg10-urine values of NT-proBNP corrected for urine creatinie showed a correlation coefficient of r = 0,902 (P |
| doi_str_mv | 10.1016/j.cca.2020.06.015 |
| format | Article |
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Plasma NT-proBNP (N-terminal prohormone of brain natriuretic peptide) is an established clinical biomarker for children with congenital heart disease. In adult studies the relation between plasma and urinary NT-proBNP has been investigated with a good correlation. Considering the age dependence of NT-proBNP in healthy children and the age dependence of kidney function, an investigation of the correlation between NT-proBNP plasma and urinary values in children of different ages is necessary. We analyzed plasma and urine samples of 33 children (mean age 7 months) with congenital heart disease before surgery. Plasma and urinary creatinine were also measured to evaluate the influence of kidney function. A Pearson correlation between Lg10-plasma and Lg10-urine values of NT-proBNP corrected for urine creatinie showed a correlation coefficient of r = 0,902 (P < 0,000) without discriminating for age.
This study demonstrates that urinary NT-proBNP values correlate well with plasma NT-proBNP values in infants and toddlers and that single random urine sample corrected to urine-creatinine can be used as an alternative to plasma samples. The use of urinary biomarkers could help reduce the need of stressful blood sampling in infants and children.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/j.cca.2020.06.015</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>BNP ; Congenital heart disease ; NT-proBNP ; Urinary value</subject><ispartof>Clinica chimica acta, 2020-10, Vol.509, p.224-227</ispartof><rights>2020 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c330t-18cefd0953d9b51e6b58785b6d146525e6962df6217a6f9e0d6a22cde305706a3</citedby><cites>FETCH-LOGICAL-c330t-18cefd0953d9b51e6b58785b6d146525e6962df6217a6f9e0d6a22cde305706a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009898120302795$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Müller, Nicole</creatorcontrib><creatorcontrib>Rothkegel, Stefanie T.</creatorcontrib><creatorcontrib>Boerter, Nicolas</creatorcontrib><creatorcontrib>Breuer, Johannes</creatorcontrib><creatorcontrib>Freudenthal, Noa J.</creatorcontrib><title>Urinary values of NT-proBNP in children with congenital heart disease – Is it feasible?</title><title>Clinica chimica acta</title><description>•NT-ProBNP can be determined in urine of children with congenital heart disease.•Spot-urine corrected to urine-creatinine can be used as an alternative to plasma samples.•Blood sampling can be reduced in traumatized children with congenital heart disease.
Plasma NT-proBNP (N-terminal prohormone of brain natriuretic peptide) is an established clinical biomarker for children with congenital heart disease. In adult studies the relation between plasma and urinary NT-proBNP has been investigated with a good correlation. Considering the age dependence of NT-proBNP in healthy children and the age dependence of kidney function, an investigation of the correlation between NT-proBNP plasma and urinary values in children of different ages is necessary. We analyzed plasma and urine samples of 33 children (mean age 7 months) with congenital heart disease before surgery. Plasma and urinary creatinine were also measured to evaluate the influence of kidney function. A Pearson correlation between Lg10-plasma and Lg10-urine values of NT-proBNP corrected for urine creatinie showed a correlation coefficient of r = 0,902 (P < 0,000) without discriminating for age.
This study demonstrates that urinary NT-proBNP values correlate well with plasma NT-proBNP values in infants and toddlers and that single random urine sample corrected to urine-creatinine can be used as an alternative to plasma samples. The use of urinary biomarkers could help reduce the need of stressful blood sampling in infants and children.</description><subject>BNP</subject><subject>Congenital heart disease</subject><subject>NT-proBNP</subject><subject>Urinary value</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kL1OAzEQhC0EEiHwAHQuae5Y-2KfLQoEiD8pAoqkoLIce484Ou7AvoDoeAfekCfBKNRUq5FmRjsfIYcMSgZMHq9K52zJgUMJsgQmtsiIqboqqonm22QEALpQWrFdspfSKssJSDYij_MYOhs_6Jtt15ho39C7WfES-_O7Bxo66pah9RE7-h6GJXV994RdGGxLl2jjQH1IaBPS788veptoGGiTdVi0eLpPdhrbJjz4u2Myv7qcXdwU0_vr24uzaeGqCoaCKYeNBy0qrxeCoVwIVSuxkJ5NpOACpZbcN5Kz2spGI3hpOXceKxA1SFuNydGmNz_9micM5jkkh21rO-zXyfAJ41opVetsZRuri31KERvzEsNzXm8YmF-MZmUyRvOL0YA0GWPOnGwymDe8BYwmuYCdQx8iusH4PvyT_gHL3HpE</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Müller, Nicole</creator><creator>Rothkegel, Stefanie T.</creator><creator>Boerter, Nicolas</creator><creator>Breuer, Johannes</creator><creator>Freudenthal, Noa J.</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202010</creationdate><title>Urinary values of NT-proBNP in children with congenital heart disease – Is it feasible?</title><author>Müller, Nicole ; Rothkegel, Stefanie T. ; Boerter, Nicolas ; Breuer, Johannes ; Freudenthal, Noa J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c330t-18cefd0953d9b51e6b58785b6d146525e6962df6217a6f9e0d6a22cde305706a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>BNP</topic><topic>Congenital heart disease</topic><topic>NT-proBNP</topic><topic>Urinary value</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Müller, Nicole</creatorcontrib><creatorcontrib>Rothkegel, Stefanie T.</creatorcontrib><creatorcontrib>Boerter, Nicolas</creatorcontrib><creatorcontrib>Breuer, Johannes</creatorcontrib><creatorcontrib>Freudenthal, Noa J.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Müller, Nicole</au><au>Rothkegel, Stefanie T.</au><au>Boerter, Nicolas</au><au>Breuer, Johannes</au><au>Freudenthal, Noa J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary values of NT-proBNP in children with congenital heart disease – Is it feasible?</atitle><jtitle>Clinica chimica acta</jtitle><date>2020-10</date><risdate>2020</risdate><volume>509</volume><spage>224</spage><epage>227</epage><pages>224-227</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>•NT-ProBNP can be determined in urine of children with congenital heart disease.•Spot-urine corrected to urine-creatinine can be used as an alternative to plasma samples.•Blood sampling can be reduced in traumatized children with congenital heart disease.
Plasma NT-proBNP (N-terminal prohormone of brain natriuretic peptide) is an established clinical biomarker for children with congenital heart disease. In adult studies the relation between plasma and urinary NT-proBNP has been investigated with a good correlation. Considering the age dependence of NT-proBNP in healthy children and the age dependence of kidney function, an investigation of the correlation between NT-proBNP plasma and urinary values in children of different ages is necessary. We analyzed plasma and urine samples of 33 children (mean age 7 months) with congenital heart disease before surgery. Plasma and urinary creatinine were also measured to evaluate the influence of kidney function. A Pearson correlation between Lg10-plasma and Lg10-urine values of NT-proBNP corrected for urine creatinie showed a correlation coefficient of r = 0,902 (P < 0,000) without discriminating for age.
This study demonstrates that urinary NT-proBNP values correlate well with plasma NT-proBNP values in infants and toddlers and that single random urine sample corrected to urine-creatinine can be used as an alternative to plasma samples. The use of urinary biomarkers could help reduce the need of stressful blood sampling in infants and children.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.cca.2020.06.015</doi><tpages>4</tpages></addata></record> |
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| subjects | BNP Congenital heart disease NT-proBNP Urinary value |
| title | Urinary values of NT-proBNP in children with congenital heart disease – Is it feasible? |
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