Comorbidities in pediatric alopecia areata
Background Comorbidities are associated with higher health care costs, complex management, and poorer health outcomes. Identification and treatment of comorbid conditions in paediatric alopecia areata (AA) patients could provide an opportunity to improve health outcomes. Objectives To determine the...
Gespeichert in:
| Veröffentlicht in: | Journal of the European Academy of Dermatology and Venereology 2020-12, Vol.34 (12), p.2898-2901 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2901 |
|---|---|
| container_issue | 12 |
| container_start_page | 2898 |
| container_title | Journal of the European Academy of Dermatology and Venereology |
| container_volume | 34 |
| creator | Conic, R.Z. Tamashunas, N.L. Damiani, G. Fabbrocini, G. Cantelli, M. Bergfeld, W.F. |
| description | Background
Comorbidities are associated with higher health care costs, complex management, and poorer health outcomes. Identification and treatment of comorbid conditions in paediatric alopecia areata (AA) patients could provide an opportunity to improve health outcomes.
Objectives
To determine the prevalence of comorbidities among paediatric patients with AA using a large de‐identified aggregated patient database.
Methods
This is a cross‐sectional study using aggregated health record data through April 1, 2019. Patients ≤18 years of age, with alopecia areata (n = 3510) and without alopecia areata (n = 8 310 710) were identified. The primary outcome was the prevalence of comorbidities among AA patients.
Results
Of the 8 314 220 paediatric patients, 3510 (1570 males and 1940 females) had a diagnosis of alopecia areata. The most common comorbidities included atopic dermatitis (17.4% vs. 2.2% controls, OR 9.2, 95% CI 8.55–10.18, P |
| doi_str_mv | 10.1111/jdv.16727 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2412988720</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2412988720</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3257-5e0b6a146bc76a6eca4a0d8e7e226323ae0def1271f8a79c415599fe5debdbae3</originalsourceid><addsrcrecordid>eNp1kDtPwzAURi0EoqUw8AdQRkBK60dixyMqb1ViAVbrxr6RXCVNsFNQ_z2BABt3ucvR0adDyCmjczbcYu3e50wqrvbIlGWySAUtxD6ZUs1lqnWuJ-QoxjWllLG8OCQTwXPBmGBTcrlsmzaU3vneY0z8JunQeeiDtwnUbYfWQwIBoYdjclBBHfHk58_Iy-3N8_I-XT3dPSyvVqkdtCrNkZYShhmlVRIkWsiAugIVci4FF4DUYcW4YlUBStuM5bnWFeYOS1cCihk5H71daN-2GHvT-GixrmGD7TYanjGui0JxOqAXI2pDG2PAynTBNxB2hlHzlcYMacx3moE9-9FuywbdH_nbYgAWI_Dha9z9bzKP16-j8hPgf2zz</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2412988720</pqid></control><display><type>article</type><title>Comorbidities in pediatric alopecia areata</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Conic, R.Z. ; Tamashunas, N.L. ; Damiani, G. ; Fabbrocini, G. ; Cantelli, M. ; Bergfeld, W.F.</creator><creatorcontrib>Conic, R.Z. ; Tamashunas, N.L. ; Damiani, G. ; Fabbrocini, G. ; Cantelli, M. ; Bergfeld, W.F. ; Young Dermatologists Italian Network ; Young Dermatologists Italian Network</creatorcontrib><description><![CDATA[Background
Comorbidities are associated with higher health care costs, complex management, and poorer health outcomes. Identification and treatment of comorbid conditions in paediatric alopecia areata (AA) patients could provide an opportunity to improve health outcomes.
Objectives
To determine the prevalence of comorbidities among paediatric patients with AA using a large de‐identified aggregated patient database.
Methods
This is a cross‐sectional study using aggregated health record data through April 1, 2019. Patients ≤18 years of age, with alopecia areata (n = 3510) and without alopecia areata (n = 8 310 710) were identified. The primary outcome was the prevalence of comorbidities among AA patients.
Results
Of the 8 314 220 paediatric patients, 3510 (1570 males and 1940 females) had a diagnosis of alopecia areata. The most common comorbidities included atopic dermatitis (17.4% vs. 2.2% controls, OR 9.2, 95% CI 8.55–10.18, P < 0.001), anaemia (7.7% vs. 2.4% controls, OR 3.4, 95% CI 3.06–3.92, P < 0.001), obesity (5.7% vs. 1.1% controls, OR 5.6, 95% CI 4.76–6.34, P < 0.001), vitamin D deficiency (5.1% vs. 0.4% controls, OR 14.7, 95% CI 13.5–18.1, P < 0.001), hypothyroidism (2.6% vs. 0.2% controls, OR 12, 95% CI 10.73–15.9, P < 0.001), vitiligo (1.4% vs. 0.04% controls, OR 32.2, 95% CI 24.01–42.1, P < 0.001), psoriasis (1.4% vs. 0.07% controls, OR 20.6, 95% CI 15.55–27.2, P < 0.001), hyperlipidemia (1.4% vs. 0.2% controls, OR 5.9, 95% CI 4.4–7.7, P < 0.001), and depression (2.6% vs. 0.6% controls, OR 4.8, 95% CI 5.09–9.45, P < 0.001).
Conclusions
Findings from this study suggest that children with AA are more likely to have certain autoimmune and metabolic disorders than the general paediatric population. Paediatric AA patients display a severe burden of autoimmune and metabolic diseases, thus in daily practice, dermatologists might consider multidisciplinary management in these patients.]]></description><identifier>ISSN: 0926-9959</identifier><identifier>EISSN: 1468-3083</identifier><identifier>DOI: 10.1111/jdv.16727</identifier><identifier>PMID: 32531131</identifier><language>eng</language><publisher>England</publisher><subject>Alopecia Areata - epidemiology ; Child ; Comorbidity ; Cross-Sectional Studies ; Dermatitis, Atopic - epidemiology ; Female ; Humans ; Male ; Vitiligo - epidemiology</subject><ispartof>Journal of the European Academy of Dermatology and Venereology, 2020-12, Vol.34 (12), p.2898-2901</ispartof><rights>2020 European Academy of Dermatology and Venereology</rights><rights>2020 European Academy of Dermatology and Venereology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3257-5e0b6a146bc76a6eca4a0d8e7e226323ae0def1271f8a79c415599fe5debdbae3</citedby><cites>FETCH-LOGICAL-c3257-5e0b6a146bc76a6eca4a0d8e7e226323ae0def1271f8a79c415599fe5debdbae3</cites><orcidid>0000-0002-9209-2883 ; 0000-0002-2390-6505</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjdv.16727$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjdv.16727$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32531131$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Conic, R.Z.</creatorcontrib><creatorcontrib>Tamashunas, N.L.</creatorcontrib><creatorcontrib>Damiani, G.</creatorcontrib><creatorcontrib>Fabbrocini, G.</creatorcontrib><creatorcontrib>Cantelli, M.</creatorcontrib><creatorcontrib>Bergfeld, W.F.</creatorcontrib><creatorcontrib>Young Dermatologists Italian Network</creatorcontrib><creatorcontrib>Young Dermatologists Italian Network</creatorcontrib><title>Comorbidities in pediatric alopecia areata</title><title>Journal of the European Academy of Dermatology and Venereology</title><addtitle>J Eur Acad Dermatol Venereol</addtitle><description><![CDATA[Background
Comorbidities are associated with higher health care costs, complex management, and poorer health outcomes. Identification and treatment of comorbid conditions in paediatric alopecia areata (AA) patients could provide an opportunity to improve health outcomes.
Objectives
To determine the prevalence of comorbidities among paediatric patients with AA using a large de‐identified aggregated patient database.
Methods
This is a cross‐sectional study using aggregated health record data through April 1, 2019. Patients ≤18 years of age, with alopecia areata (n = 3510) and without alopecia areata (n = 8 310 710) were identified. The primary outcome was the prevalence of comorbidities among AA patients.
Results
Of the 8 314 220 paediatric patients, 3510 (1570 males and 1940 females) had a diagnosis of alopecia areata. The most common comorbidities included atopic dermatitis (17.4% vs. 2.2% controls, OR 9.2, 95% CI 8.55–10.18, P < 0.001), anaemia (7.7% vs. 2.4% controls, OR 3.4, 95% CI 3.06–3.92, P < 0.001), obesity (5.7% vs. 1.1% controls, OR 5.6, 95% CI 4.76–6.34, P < 0.001), vitamin D deficiency (5.1% vs. 0.4% controls, OR 14.7, 95% CI 13.5–18.1, P < 0.001), hypothyroidism (2.6% vs. 0.2% controls, OR 12, 95% CI 10.73–15.9, P < 0.001), vitiligo (1.4% vs. 0.04% controls, OR 32.2, 95% CI 24.01–42.1, P < 0.001), psoriasis (1.4% vs. 0.07% controls, OR 20.6, 95% CI 15.55–27.2, P < 0.001), hyperlipidemia (1.4% vs. 0.2% controls, OR 5.9, 95% CI 4.4–7.7, P < 0.001), and depression (2.6% vs. 0.6% controls, OR 4.8, 95% CI 5.09–9.45, P < 0.001).
Conclusions
Findings from this study suggest that children with AA are more likely to have certain autoimmune and metabolic disorders than the general paediatric population. Paediatric AA patients display a severe burden of autoimmune and metabolic diseases, thus in daily practice, dermatologists might consider multidisciplinary management in these patients.]]></description><subject>Alopecia Areata - epidemiology</subject><subject>Child</subject><subject>Comorbidity</subject><subject>Cross-Sectional Studies</subject><subject>Dermatitis, Atopic - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Vitiligo - epidemiology</subject><issn>0926-9959</issn><issn>1468-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAURi0EoqUw8AdQRkBK60dixyMqb1ViAVbrxr6RXCVNsFNQ_z2BABt3ucvR0adDyCmjczbcYu3e50wqrvbIlGWySAUtxD6ZUs1lqnWuJ-QoxjWllLG8OCQTwXPBmGBTcrlsmzaU3vneY0z8JunQeeiDtwnUbYfWQwIBoYdjclBBHfHk58_Iy-3N8_I-XT3dPSyvVqkdtCrNkZYShhmlVRIkWsiAugIVci4FF4DUYcW4YlUBStuM5bnWFeYOS1cCihk5H71daN-2GHvT-GixrmGD7TYanjGui0JxOqAXI2pDG2PAynTBNxB2hlHzlcYMacx3moE9-9FuywbdH_nbYgAWI_Dha9z9bzKP16-j8hPgf2zz</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Conic, R.Z.</creator><creator>Tamashunas, N.L.</creator><creator>Damiani, G.</creator><creator>Fabbrocini, G.</creator><creator>Cantelli, M.</creator><creator>Bergfeld, W.F.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9209-2883</orcidid><orcidid>https://orcid.org/0000-0002-2390-6505</orcidid></search><sort><creationdate>202012</creationdate><title>Comorbidities in pediatric alopecia areata</title><author>Conic, R.Z. ; Tamashunas, N.L. ; Damiani, G. ; Fabbrocini, G. ; Cantelli, M. ; Bergfeld, W.F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3257-5e0b6a146bc76a6eca4a0d8e7e226323ae0def1271f8a79c415599fe5debdbae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Alopecia Areata - epidemiology</topic><topic>Child</topic><topic>Comorbidity</topic><topic>Cross-Sectional Studies</topic><topic>Dermatitis, Atopic - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Vitiligo - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Conic, R.Z.</creatorcontrib><creatorcontrib>Tamashunas, N.L.</creatorcontrib><creatorcontrib>Damiani, G.</creatorcontrib><creatorcontrib>Fabbrocini, G.</creatorcontrib><creatorcontrib>Cantelli, M.</creatorcontrib><creatorcontrib>Bergfeld, W.F.</creatorcontrib><creatorcontrib>Young Dermatologists Italian Network</creatorcontrib><creatorcontrib>Young Dermatologists Italian Network</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the European Academy of Dermatology and Venereology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Conic, R.Z.</au><au>Tamashunas, N.L.</au><au>Damiani, G.</au><au>Fabbrocini, G.</au><au>Cantelli, M.</au><au>Bergfeld, W.F.</au><aucorp>Young Dermatologists Italian Network</aucorp><aucorp>Young Dermatologists Italian Network</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comorbidities in pediatric alopecia areata</atitle><jtitle>Journal of the European Academy of Dermatology and Venereology</jtitle><addtitle>J Eur Acad Dermatol Venereol</addtitle><date>2020-12</date><risdate>2020</risdate><volume>34</volume><issue>12</issue><spage>2898</spage><epage>2901</epage><pages>2898-2901</pages><issn>0926-9959</issn><eissn>1468-3083</eissn><abstract><![CDATA[Background
Comorbidities are associated with higher health care costs, complex management, and poorer health outcomes. Identification and treatment of comorbid conditions in paediatric alopecia areata (AA) patients could provide an opportunity to improve health outcomes.
Objectives
To determine the prevalence of comorbidities among paediatric patients with AA using a large de‐identified aggregated patient database.
Methods
This is a cross‐sectional study using aggregated health record data through April 1, 2019. Patients ≤18 years of age, with alopecia areata (n = 3510) and without alopecia areata (n = 8 310 710) were identified. The primary outcome was the prevalence of comorbidities among AA patients.
Results
Of the 8 314 220 paediatric patients, 3510 (1570 males and 1940 females) had a diagnosis of alopecia areata. The most common comorbidities included atopic dermatitis (17.4% vs. 2.2% controls, OR 9.2, 95% CI 8.55–10.18, P < 0.001), anaemia (7.7% vs. 2.4% controls, OR 3.4, 95% CI 3.06–3.92, P < 0.001), obesity (5.7% vs. 1.1% controls, OR 5.6, 95% CI 4.76–6.34, P < 0.001), vitamin D deficiency (5.1% vs. 0.4% controls, OR 14.7, 95% CI 13.5–18.1, P < 0.001), hypothyroidism (2.6% vs. 0.2% controls, OR 12, 95% CI 10.73–15.9, P < 0.001), vitiligo (1.4% vs. 0.04% controls, OR 32.2, 95% CI 24.01–42.1, P < 0.001), psoriasis (1.4% vs. 0.07% controls, OR 20.6, 95% CI 15.55–27.2, P < 0.001), hyperlipidemia (1.4% vs. 0.2% controls, OR 5.9, 95% CI 4.4–7.7, P < 0.001), and depression (2.6% vs. 0.6% controls, OR 4.8, 95% CI 5.09–9.45, P < 0.001).
Conclusions
Findings from this study suggest that children with AA are more likely to have certain autoimmune and metabolic disorders than the general paediatric population. Paediatric AA patients display a severe burden of autoimmune and metabolic diseases, thus in daily practice, dermatologists might consider multidisciplinary management in these patients.]]></abstract><cop>England</cop><pmid>32531131</pmid><doi>10.1111/jdv.16727</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-9209-2883</orcidid><orcidid>https://orcid.org/0000-0002-2390-6505</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0926-9959 |
| ispartof | Journal of the European Academy of Dermatology and Venereology, 2020-12, Vol.34 (12), p.2898-2901 |
| issn | 0926-9959 1468-3083 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2412988720 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Alopecia Areata - epidemiology Child Comorbidity Cross-Sectional Studies Dermatitis, Atopic - epidemiology Female Humans Male Vitiligo - epidemiology |
| title | Comorbidities in pediatric alopecia areata |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T16%3A55%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comorbidities%20in%20pediatric%20alopecia%20areata&rft.jtitle=Journal%20of%20the%20European%20Academy%20of%20Dermatology%20and%20Venereology&rft.au=Conic,%20R.Z.&rft.aucorp=Young%20Dermatologists%20Italian%20Network&rft.date=2020-12&rft.volume=34&rft.issue=12&rft.spage=2898&rft.epage=2901&rft.pages=2898-2901&rft.issn=0926-9959&rft.eissn=1468-3083&rft_id=info:doi/10.1111/jdv.16727&rft_dat=%3Cproquest_cross%3E2412988720%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2412988720&rft_id=info:pmid/32531131&rfr_iscdi=true |