Bundle of Coated Devices to Reduce Nosocomial Infections in the Intensive Care Unit. CRITIC Pilot Randomized Controlled Trial
Grion et al present a study that aims to assess the feasibility of a randomized controlled trial on simultaneous insertion of gold/silver/palladium-coated devices versus uncoated devices in severely ill patients, which required sequential insertion of all three devices (an ETT, CVC, and UC) for supp...
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| Veröffentlicht in: | Annals of the American Thoracic Society 2020-10, Vol.17 (10), p.1257-1263 |
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| creator | Zampieri, Fernando G. de Oliveira, Neymar Elias Nassar, Antonio Paulo de Oliveira Manoel, Airton Leonardo Grion, Cintia Lacerda, Fábio H. Maia, Israel Thompson, Marlus Giancursi, Thiago Simões de Aquino Martins, Priscilla Lisboa, Thiago Abait, Tamiris Damiani, Lucas P. Machado, Flávia R. Cavalcanti, Alexandre B. Prado, Livia Pereira Miranda Nuevo, Ricardo Costa Santos, Silvana Soares dos Martins, Eliana Viera do Nascimento Zandonai, Cássio Gobbo, Thaís Fonseca e Pereira, Érica Juliane da Silva Uka, Christiane Tokiko Marçal Souza, Maria Aparecida de |
| description | Grion et al present a study that aims to assess the feasibility of a randomized controlled trial on simultaneous insertion of gold/silver/palladium-coated devices versus uncoated devices in severely ill patients, which required sequential insertion of all three devices (an ETT, CVC, and UC) for support in the intensive care unit (ICU). Patients who required simultaneous insertion of an ETT, CVC, and UC were randomized to treatment with coated versus uncoated devices, which were used as necessary for up to 28 days. The primary endpoint was feasibility, defined as the trial being able to enroll enough participants to have the sample size necessary for its secondary primary endpoint (estimating sepsis incidence in this population) in less than 1 year and for estimating the number of admitted patients who require simultaneous insertion of all three devices. Secondary endpoints included the incidence of sepsis and device-associated infections (ventilator-associated pneumonia, catheter-related bloodstream infection, and catheter-related urinary-tract infection) within each group as well as the number of days alive and free of antibiotics during the ICU stay. All events were adjudicated. |
| doi_str_mv | 10.1513/AnnalsATS.202003-206OC |
| format | Article |
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CRITIC Pilot Randomized Controlled Trial</title><source>American Thoracic Society (ATS) Journals Online</source><source>Alma/SFX Local Collection</source><creator>Zampieri, Fernando G. ; de Oliveira, Neymar Elias ; Nassar, Antonio Paulo ; de Oliveira Manoel, Airton Leonardo ; Grion, Cintia ; Lacerda, Fábio H. ; Maia, Israel ; Thompson, Marlus ; Giancursi, Thiago Simões ; de Aquino Martins, Priscilla ; Lisboa, Thiago ; Abait, Tamiris ; Damiani, Lucas P. ; Machado, Flávia R. ; Cavalcanti, Alexandre B. ; Prado, Livia Pereira Miranda ; Nuevo, Ricardo Costa ; Santos, Silvana Soares dos ; Martins, Eliana Viera do Nascimento ; Zandonai, Cássio ; Gobbo, Thaís Fonseca e ; Pereira, Érica Juliane da Silva ; Uka, Christiane Tokiko Marçal ; Souza, Maria Aparecida de</creator><creatorcontrib>Zampieri, Fernando G. ; de Oliveira, Neymar Elias ; Nassar, Antonio Paulo ; de Oliveira Manoel, Airton Leonardo ; Grion, Cintia ; Lacerda, Fábio H. ; Maia, Israel ; Thompson, Marlus ; Giancursi, Thiago Simões ; de Aquino Martins, Priscilla ; Lisboa, Thiago ; Abait, Tamiris ; Damiani, Lucas P. ; Machado, Flávia R. ; Cavalcanti, Alexandre B. ; Prado, Livia Pereira Miranda ; Nuevo, Ricardo Costa ; Santos, Silvana Soares dos ; Martins, Eliana Viera do Nascimento ; Zandonai, Cássio ; Gobbo, Thaís Fonseca e ; Pereira, Érica Juliane da Silva ; Uka, Christiane Tokiko Marçal ; Souza, Maria Aparecida de</creatorcontrib><description>Grion et al present a study that aims to assess the feasibility of a randomized controlled trial on simultaneous insertion of gold/silver/palladium-coated devices versus uncoated devices in severely ill patients, which required sequential insertion of all three devices (an ETT, CVC, and UC) for support in the intensive care unit (ICU). Patients who required simultaneous insertion of an ETT, CVC, and UC were randomized to treatment with coated versus uncoated devices, which were used as necessary for up to 28 days. The primary endpoint was feasibility, defined as the trial being able to enroll enough participants to have the sample size necessary for its secondary primary endpoint (estimating sepsis incidence in this population) in less than 1 year and for estimating the number of admitted patients who require simultaneous insertion of all three devices. Secondary endpoints included the incidence of sepsis and device-associated infections (ventilator-associated pneumonia, catheter-related bloodstream infection, and catheter-related urinary-tract infection) within each group as well as the number of days alive and free of antibiotics during the ICU stay. 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Secondary endpoints included the incidence of sepsis and device-associated infections (ventilator-associated pneumonia, catheter-related bloodstream infection, and catheter-related urinary-tract infection) within each group as well as the number of days alive and free of antibiotics during the ICU stay. All events were adjudicated.</description><subject>Clinical trials</subject><subject>Intensive care</subject><subject>Medical education</subject><subject>Nosocomial infections</subject><subject>Pneumonia</subject><subject>Sepsis</subject><subject>Urinary tract infections</subject><issn>2329-6933</issn><issn>2325-6621</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpdkVtLAzEQhRdRsGj_ggR88WVrrnt5rOutUKzU9nnJZmcxZZvUJCso-N9NrfjgvMxh-OYwzEmSC4InRBB2PTVG9n66eplQTDFmKcXZojpKRpRRkWYZJcc_ukyzkrHTZOz9BscqBCnycpR83Qym7QHZDlVWBmjRLbxrBR4Fi5bQDgrQk_VW2a2WPZqZDlTQ1nikDQqvECcBjNfvgCrpAK2NDhNULWerWYWedW8DWkrTxu3P6F1ZE5zt-yhXLvqdJyddPB_Gv_0sWd_frarHdL54mFXTeaoYyUJaUiG4LDMJArOcyIzmijPWslY2hWSc5Iop0TZcSU471cgmJ7wE1gkKpWowO0uuDr47Z98G8KHeaq-g76UBO_iackLLohCFiOjlP3RjB7d_cqQEFoTnnEQqO1DKWe8ddPXO6a10HzXB9T6Y-i-Y-hBM_RMM-wbmJILQ</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Zampieri, Fernando G.</creator><creator>de Oliveira, Neymar Elias</creator><creator>Nassar, Antonio Paulo</creator><creator>de Oliveira Manoel, Airton Leonardo</creator><creator>Grion, Cintia</creator><creator>Lacerda, Fábio H.</creator><creator>Maia, Israel</creator><creator>Thompson, Marlus</creator><creator>Giancursi, Thiago Simões</creator><creator>de Aquino Martins, Priscilla</creator><creator>Lisboa, Thiago</creator><creator>Abait, Tamiris</creator><creator>Damiani, Lucas P.</creator><creator>Machado, Flávia R.</creator><creator>Cavalcanti, Alexandre B.</creator><creator>Prado, Livia Pereira Miranda</creator><creator>Nuevo, Ricardo Costa</creator><creator>Santos, Silvana Soares dos</creator><creator>Martins, Eliana Viera do Nascimento</creator><creator>Zandonai, Cássio</creator><creator>Gobbo, Thaís Fonseca e</creator><creator>Pereira, Érica Juliane da Silva</creator><creator>Uka, Christiane Tokiko Marçal</creator><creator>Souza, Maria Aparecida de</creator><general>American Thoracic Society</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3467-5287</orcidid><orcidid>https://orcid.org/0000-0001-9315-6386</orcidid><orcidid>https://orcid.org/0000-0002-5836-3379</orcidid></search><sort><creationdate>20201001</creationdate><title>Bundle of Coated Devices to Reduce Nosocomial Infections in the Intensive Care Unit. 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| fulltext | fulltext |
| identifier | ISSN: 2329-6933 |
| ispartof | Annals of the American Thoracic Society, 2020-10, Vol.17 (10), p.1257-1263 |
| issn | 2329-6933 2325-6621 |
| language | eng |
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| source | American Thoracic Society (ATS) Journals Online; Alma/SFX Local Collection |
| subjects | Clinical trials Intensive care Medical education Nosocomial infections Pneumonia Sepsis Urinary tract infections |
| title | Bundle of Coated Devices to Reduce Nosocomial Infections in the Intensive Care Unit. CRITIC Pilot Randomized Controlled Trial |
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