Side effects of proton beam therapy of choroidal melanoma in dependence of the dose to the optic disc and the irradiated length of the optic nerve
Purpose To analyze the impact of the dose to the optic disc and the irradiated length of the optic nerve on radiation-induced optic neuropathy, radiation-induced retinopathy, iris neovascularization, secondary glaucoma, enucleation, and local tumor control after proton beam therapy (PBT) of choroida...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 2020-11, Vol.258 (11), p.2523-2533 |
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| creator | Riechardt, Aline I. Stroux, Andrea Seibel, Ira Heufelder, Jens Zeitz, Oliver Böhmer, Dirk Joussen, Antonia M. Gollrad, Johannes |
| description | Purpose
To analyze the impact of the dose to the optic disc and the irradiated length of the optic nerve on radiation-induced optic neuropathy, radiation-induced retinopathy, iris neovascularization, secondary glaucoma, enucleation, and local tumor control after proton beam therapy (PBT) of choroidal melanoma.
Method
Retrospective analysis of 1129 patients, who received primary PBT for the treatment of choroidal melanoma with a dose of 60 cobalt gray equivalents (CGE) between 1998 and 2013 at the Helmholtz-Zentrum Berlin, Germany. Kaplan-Meier curves and logrank test have been used for time-to-event analyses. Adjustment for potential confounders was done using multiple Cox regression models with forward and backward selection.
Results
We found a significant correlation between the irradiated length of the optic nerve and the dose to the optic disc (correlation coefficient, 0.93). Multivariate Cox regression revealed the dose to the optic disc as an independent predictive risk factor for the development of radiation-induced optic neuropathy (
p
< 0.001, HR 1.023, 95 CI 1.016–1.029), iris neovascularization (
p
< 0.001, HR 1.013, 95% CI 1.008–1.019), secondary glaucoma (
p
< 0.001, HR 1.017, 95% CI: 1.011-1.023) and enucleation (
p
< 0.001, HR 1.037, 95% CI 1.020-1.053). The irradiated length of the optic nerve was not a statistically independent predictive risk factor in multivariate analysis.
Conclusion
Our data implicate the predominance of the dose to the optic disc over the irradiated length of the optic nerve regarding radiation-induced optic neuropathy, iris neovascularization, secondary glaucoma, and enucleation. |
| doi_str_mv | 10.1007/s00417-020-04780-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2412987384</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2471812726</sourcerecordid><originalsourceid>FETCH-LOGICAL-c352t-7e1afa8b6dee18b7792586392e7b73103933a37b7d76cc4d600665207f6e80a63</originalsourceid><addsrcrecordid>eNp9kU9r3DAQxUVIIJs_XyAnQS69OB1JtqU9htAmhUAPTSA3oZXGu15syZG0hf0a_cTRrlsKPfQ0w_B7j3k8Qm4Y3DEA-TkB1ExWwKGCWiqo9idkwWrRVBL42ylZgOSsUoK_nZOLlLZQeNGwBfn1o3dIsevQ5kRDR6cYcvB0hWakeYPRTPvD2W5CDL0zAx1xMD6MhvaeOpzQO_QWD0zBqQsJaQ7HPUy5t9T1yVLj3fHUx2hcbzI6OqBf580f3cx6jD_xipx1Zkh4_XtektevX14enqrn74_fHu6fKysaniuJzHRGrVqHyNRKyiVvVCuWHOVKCgZiKYQRZXeytbZ2LUDbNhxk16IC04pL8mn2LZHfd5iyHsurOJR4GHZJ85rxpZJC1QW9_Qfdhl305btCSaYYl_xgyGfKxpBSxE5PsR9N3GsG-lCTnmvSpSZ9rEnvi0jMolRgv8b41_o_qg_sJZZ9</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2471812726</pqid></control><display><type>article</type><title>Side effects of proton beam therapy of choroidal melanoma in dependence of the dose to the optic disc and the irradiated length of the optic nerve</title><source>Springer Nature - Complete Springer Journals</source><creator>Riechardt, Aline I. ; Stroux, Andrea ; Seibel, Ira ; Heufelder, Jens ; Zeitz, Oliver ; Böhmer, Dirk ; Joussen, Antonia M. ; Gollrad, Johannes</creator><creatorcontrib>Riechardt, Aline I. ; Stroux, Andrea ; Seibel, Ira ; Heufelder, Jens ; Zeitz, Oliver ; Böhmer, Dirk ; Joussen, Antonia M. ; Gollrad, Johannes</creatorcontrib><description>Purpose
To analyze the impact of the dose to the optic disc and the irradiated length of the optic nerve on radiation-induced optic neuropathy, radiation-induced retinopathy, iris neovascularization, secondary glaucoma, enucleation, and local tumor control after proton beam therapy (PBT) of choroidal melanoma.
Method
Retrospective analysis of 1129 patients, who received primary PBT for the treatment of choroidal melanoma with a dose of 60 cobalt gray equivalents (CGE) between 1998 and 2013 at the Helmholtz-Zentrum Berlin, Germany. Kaplan-Meier curves and logrank test have been used for time-to-event analyses. Adjustment for potential confounders was done using multiple Cox regression models with forward and backward selection.
Results
We found a significant correlation between the irradiated length of the optic nerve and the dose to the optic disc (correlation coefficient, 0.93). Multivariate Cox regression revealed the dose to the optic disc as an independent predictive risk factor for the development of radiation-induced optic neuropathy (
p
< 0.001, HR 1.023, 95 CI 1.016–1.029), iris neovascularization (
p
< 0.001, HR 1.013, 95% CI 1.008–1.019), secondary glaucoma (
p
< 0.001, HR 1.017, 95% CI: 1.011-1.023) and enucleation (
p
< 0.001, HR 1.037, 95% CI 1.020-1.053). The irradiated length of the optic nerve was not a statistically independent predictive risk factor in multivariate analysis.
Conclusion
Our data implicate the predominance of the dose to the optic disc over the irradiated length of the optic nerve regarding radiation-induced optic neuropathy, iris neovascularization, secondary glaucoma, and enucleation.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-020-04780-y</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cobalt ; Enucleation ; Glaucoma ; Iris ; Medicine ; Medicine & Public Health ; Melanoma ; Multivariate analysis ; Oncology ; Ophthalmology ; Optic nerve ; Optic neuropathy ; Regression analysis ; Retinopathy ; Risk factors ; Vascularization</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2020-11, Vol.258 (11), p.2523-2533</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-7e1afa8b6dee18b7792586392e7b73103933a37b7d76cc4d600665207f6e80a63</citedby><cites>FETCH-LOGICAL-c352t-7e1afa8b6dee18b7792586392e7b73103933a37b7d76cc4d600665207f6e80a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00417-020-04780-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00417-020-04780-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Riechardt, Aline I.</creatorcontrib><creatorcontrib>Stroux, Andrea</creatorcontrib><creatorcontrib>Seibel, Ira</creatorcontrib><creatorcontrib>Heufelder, Jens</creatorcontrib><creatorcontrib>Zeitz, Oliver</creatorcontrib><creatorcontrib>Böhmer, Dirk</creatorcontrib><creatorcontrib>Joussen, Antonia M.</creatorcontrib><creatorcontrib>Gollrad, Johannes</creatorcontrib><title>Side effects of proton beam therapy of choroidal melanoma in dependence of the dose to the optic disc and the irradiated length of the optic nerve</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
To analyze the impact of the dose to the optic disc and the irradiated length of the optic nerve on radiation-induced optic neuropathy, radiation-induced retinopathy, iris neovascularization, secondary glaucoma, enucleation, and local tumor control after proton beam therapy (PBT) of choroidal melanoma.
Method
Retrospective analysis of 1129 patients, who received primary PBT for the treatment of choroidal melanoma with a dose of 60 cobalt gray equivalents (CGE) between 1998 and 2013 at the Helmholtz-Zentrum Berlin, Germany. Kaplan-Meier curves and logrank test have been used for time-to-event analyses. Adjustment for potential confounders was done using multiple Cox regression models with forward and backward selection.
Results
We found a significant correlation between the irradiated length of the optic nerve and the dose to the optic disc (correlation coefficient, 0.93). Multivariate Cox regression revealed the dose to the optic disc as an independent predictive risk factor for the development of radiation-induced optic neuropathy (
p
< 0.001, HR 1.023, 95 CI 1.016–1.029), iris neovascularization (
p
< 0.001, HR 1.013, 95% CI 1.008–1.019), secondary glaucoma (
p
< 0.001, HR 1.017, 95% CI: 1.011-1.023) and enucleation (
p
< 0.001, HR 1.037, 95% CI 1.020-1.053). The irradiated length of the optic nerve was not a statistically independent predictive risk factor in multivariate analysis.
Conclusion
Our data implicate the predominance of the dose to the optic disc over the irradiated length of the optic nerve regarding radiation-induced optic neuropathy, iris neovascularization, secondary glaucoma, and enucleation.</description><subject>Cobalt</subject><subject>Enucleation</subject><subject>Glaucoma</subject><subject>Iris</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Melanoma</subject><subject>Multivariate analysis</subject><subject>Oncology</subject><subject>Ophthalmology</subject><subject>Optic nerve</subject><subject>Optic neuropathy</subject><subject>Regression analysis</subject><subject>Retinopathy</subject><subject>Risk factors</subject><subject>Vascularization</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU9r3DAQxUVIIJs_XyAnQS69OB1JtqU9htAmhUAPTSA3oZXGu15syZG0hf0a_cTRrlsKPfQ0w_B7j3k8Qm4Y3DEA-TkB1ExWwKGCWiqo9idkwWrRVBL42ylZgOSsUoK_nZOLlLZQeNGwBfn1o3dIsevQ5kRDR6cYcvB0hWakeYPRTPvD2W5CDL0zAx1xMD6MhvaeOpzQO_QWD0zBqQsJaQ7HPUy5t9T1yVLj3fHUx2hcbzI6OqBf580f3cx6jD_xipx1Zkh4_XtektevX14enqrn74_fHu6fKysaniuJzHRGrVqHyNRKyiVvVCuWHOVKCgZiKYQRZXeytbZ2LUDbNhxk16IC04pL8mn2LZHfd5iyHsurOJR4GHZJ85rxpZJC1QW9_Qfdhl305btCSaYYl_xgyGfKxpBSxE5PsR9N3GsG-lCTnmvSpSZ9rEnvi0jMolRgv8b41_o_qg_sJZZ9</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Riechardt, Aline I.</creator><creator>Stroux, Andrea</creator><creator>Seibel, Ira</creator><creator>Heufelder, Jens</creator><creator>Zeitz, Oliver</creator><creator>Böhmer, Dirk</creator><creator>Joussen, Antonia M.</creator><creator>Gollrad, Johannes</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20201101</creationdate><title>Side effects of proton beam therapy of choroidal melanoma in dependence of the dose to the optic disc and the irradiated length of the optic nerve</title><author>Riechardt, Aline I. ; Stroux, Andrea ; Seibel, Ira ; Heufelder, Jens ; Zeitz, Oliver ; Böhmer, Dirk ; Joussen, Antonia M. ; Gollrad, Johannes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-7e1afa8b6dee18b7792586392e7b73103933a37b7d76cc4d600665207f6e80a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cobalt</topic><topic>Enucleation</topic><topic>Glaucoma</topic><topic>Iris</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Melanoma</topic><topic>Multivariate analysis</topic><topic>Oncology</topic><topic>Ophthalmology</topic><topic>Optic nerve</topic><topic>Optic neuropathy</topic><topic>Regression analysis</topic><topic>Retinopathy</topic><topic>Risk factors</topic><topic>Vascularization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Riechardt, Aline I.</creatorcontrib><creatorcontrib>Stroux, Andrea</creatorcontrib><creatorcontrib>Seibel, Ira</creatorcontrib><creatorcontrib>Heufelder, Jens</creatorcontrib><creatorcontrib>Zeitz, Oliver</creatorcontrib><creatorcontrib>Böhmer, Dirk</creatorcontrib><creatorcontrib>Joussen, Antonia M.</creatorcontrib><creatorcontrib>Gollrad, Johannes</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Riechardt, Aline I.</au><au>Stroux, Andrea</au><au>Seibel, Ira</au><au>Heufelder, Jens</au><au>Zeitz, Oliver</au><au>Böhmer, Dirk</au><au>Joussen, Antonia M.</au><au>Gollrad, Johannes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Side effects of proton beam therapy of choroidal melanoma in dependence of the dose to the optic disc and the irradiated length of the optic nerve</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><date>2020-11-01</date><risdate>2020</risdate><volume>258</volume><issue>11</issue><spage>2523</spage><epage>2533</epage><pages>2523-2533</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
To analyze the impact of the dose to the optic disc and the irradiated length of the optic nerve on radiation-induced optic neuropathy, radiation-induced retinopathy, iris neovascularization, secondary glaucoma, enucleation, and local tumor control after proton beam therapy (PBT) of choroidal melanoma.
Method
Retrospective analysis of 1129 patients, who received primary PBT for the treatment of choroidal melanoma with a dose of 60 cobalt gray equivalents (CGE) between 1998 and 2013 at the Helmholtz-Zentrum Berlin, Germany. Kaplan-Meier curves and logrank test have been used for time-to-event analyses. Adjustment for potential confounders was done using multiple Cox regression models with forward and backward selection.
Results
We found a significant correlation between the irradiated length of the optic nerve and the dose to the optic disc (correlation coefficient, 0.93). Multivariate Cox regression revealed the dose to the optic disc as an independent predictive risk factor for the development of radiation-induced optic neuropathy (
p
< 0.001, HR 1.023, 95 CI 1.016–1.029), iris neovascularization (
p
< 0.001, HR 1.013, 95% CI 1.008–1.019), secondary glaucoma (
p
< 0.001, HR 1.017, 95% CI: 1.011-1.023) and enucleation (
p
< 0.001, HR 1.037, 95% CI 1.020-1.053). The irradiated length of the optic nerve was not a statistically independent predictive risk factor in multivariate analysis.
Conclusion
Our data implicate the predominance of the dose to the optic disc over the irradiated length of the optic nerve regarding radiation-induced optic neuropathy, iris neovascularization, secondary glaucoma, and enucleation.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00417-020-04780-y</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2020-11, Vol.258 (11), p.2523-2533 |
| issn | 0721-832X 1435-702X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2412987384 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Cobalt Enucleation Glaucoma Iris Medicine Medicine & Public Health Melanoma Multivariate analysis Oncology Ophthalmology Optic nerve Optic neuropathy Regression analysis Retinopathy Risk factors Vascularization |
| title | Side effects of proton beam therapy of choroidal melanoma in dependence of the dose to the optic disc and the irradiated length of the optic nerve |
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