Reconstitution Time for Highly Concentrated Lyophilized Proteins: Role of Formulation and Protein

Lyophilized protein formulations containing highly concentrated proteins often have long reconstitution times. The goal was to understand the role of formulation in mediating the reconstitution time. Formulation variables such as % total solids, protein concentration, protein-to-sugar ratio, differe...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2020-10, Vol.109 (10), p.2975-2985
Hauptverfasser:	Kulkarni, Shreya S., Patel, Sajal M., Bogner, Robin H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amorphous Contact angle Crushing strength Crystallinity Freeze drying High concentration Lyophilization Protein formulation Reconstitution/dissolution Viscosity
Online-Zugang:	Volltext
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