Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group ‘Molecular Diagnostics and Therapy’
Precision cancer medicine (PCM) holds great promises to offer more effective therapies to patients based on molecular profiling of their individual tumours. Although the PCM approach seems intuitive, multiple conceptional and structural challenges interfere with the broad implementation of PCM into...
Gespeichert in:
| Veröffentlicht in: | European journal of cancer (1990) 2020-08, Vol.135, p.1-7 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 7 |
|---|---|
| container_issue | |
| container_start_page | 1 |
| container_title | European journal of cancer (1990) |
| container_volume | 135 |
| creator | Westphalen, C. Benedikt Bokemeyer, Carsten Büttner, Reinhard Fröhling, Stefan Gaidzik, Verena I. Glimm, Hanno Hacker, Ulrich T. Heinemann, Volker Illert, Anna L. Keilholz, Ulrich Kindler, Thomas Kirschner, Martin Schilling, Bastian Siveke, Jens T. Schroeder, Thomas Tischler, Verena Wagner, Sebastian Weichert, Wilko Zips, Daniel Loges, Sonja Bargou (Würzburg), Ralf Bläker (Leipzig), Hendrik Börries (Freiburg), Melanie Brandts (Frankfurt), Christian von Bubnoff (Lübeck), Nikolas Demes (Frankfurt), Melanie Desuki (Mainz), Alexander Döhner (Ulm), Hartmut Duyster (Freiburg), Justus Gaisa (Aachen), Nadine Heine (Bonn), Annkristin Heining (Dresden), Christoph Horak (Heidelberg), Peter Jelas (Berlin), Ivan Jost (München), Philipp J. Jung (München), Andreas Kirchner (München), Thomas Klauschen (Berlin), Frederick Kreutzfeldt (Heidelberg), Simon Kumbrink (München), Jörg Kunzmann (Würzburg), Volker Lassmann (Freiburg), Silke Metzeler (München), Klaus Möller (Ulm), Peter Ortiz-Brüchle (Aachen), Nadina Paret (Mainz), Claudia Pelusi (Bonn), Natalie Peters (Freiburg), Christoph Pfarr (München), Nicole Richter (Dresden), Daniela Riedmann (München), Kristina Rieke (Berlin), Damian Ritzel (Mainz), Christoph Schadendorf (Essen), Dirk Schildhaus (Essen), Hans-Ulrich Schorle (Bonn), Hubert Seufferlein (Ulm), Thomas Simon (Hamburg), Ronald Stenzinger (Heidelberg), Albrecht Tabatabai (Tübingen), Ghazaleh Velthaus (Hamburg), Janna-Lisa Werner (Freiburg), Martin Wild (Frankfurt), Peter J. Wolf (Köln), Jürgen |
| description | Precision cancer medicine (PCM) holds great promises to offer more effective therapies to patients based on molecular profiling of their individual tumours. Although the PCM approach seems intuitive, multiple conceptional and structural challenges interfere with the broad implementation of PCM into clinical practice. Accordingly, concerted national and international efforts are needed to guide the further development and broad adoption of PCM in Germany. With support of the ‘German Cancer Aid’ (Deutsche Krebshilfe [DKH]) a task force ‘Molecular Diagnostics and Therapy’ was implemented. In two workshops supported by the DKH, delegates from the fourteen comprehensive cancer centresidentified key topics essential to implement quality-guided, harmonized and adaptable PCM. Based on an online questionnaire and using a modified Delphi approach, nine statements were drafted and evaluated within the group. These statements could serve as a basis to define a collaborative strategy for PCM in the future with the aim to sustain and further improve its quality.
•This consenus statement originated from collaborative efforts of all fourteen Comprehensive Cancer Centres in the German Cancer Aid network.•The consensus statement is based on all centres' consent due to implementation of a modified Delphi process.•This consensus statement will serve as a framework to establish sustainable structures for precision cancer medicine in Germany. |
| doi_str_mv | 10.1016/j.ejca.2020.04.019 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2412220595</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0959804920302227</els_id><sourcerecordid>2412220595</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-e0b50b135c171a875bab3168d90773a6cd15b20d3119e58cd1de96f936d15d7f3</originalsourceid><addsrcrecordid>eNp9kcFu1DAURS0EokPhB1ggL9kkPDvjJEZs0BQKoohNWVuO8zLjIbGD7RTNrp8Ba_6sX4JHU1iysi2fe6X3DiHPGZQMWP1qX-Le6JIDhxLWJTD5gKxY28gCWsEfkhVIIYsW1vKMPIlxDwBNu4bH5KzigjMuqxX5vfHO4JwWPdIh6Al_-PCNDj7QOaCx0XpHjc5IoBP21liH1Dp6iWHS7vCa5nhEF5dIY9IJJ3SJ-oGmHdILXFI0-fIpYBd3dhyQHtut29Jt8MtM725_fvYjmmXUgV5YvXU-Jmsi1a6n1zsMej7c3f56Sh4Neoz47P48J1_fv7vefCiuvlx-3Ly9Kkwl6lQgdAI6VgnDGqbbRnS6q1jd9hKaptK16ZnoOPQVYxJFm589ynqQVZ0_-maozsnLU-8c_PcFY1KTjQbHUTv0S1R8zTjnIKTIKD-hJvgYAw5qDnbS4aAYqKMctVdHOeooR8FaZTk59OK-f-nyMv9F_trIwJsTgHnKG4tBRWMxL7-3WUZSvbf_6_8Dzp2ljw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2412220595</pqid></control><display><type>article</type><title>Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group ‘Molecular Diagnostics and Therapy’</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Westphalen, C. Benedikt ; Bokemeyer, Carsten ; Büttner, Reinhard ; Fröhling, Stefan ; Gaidzik, Verena I. ; Glimm, Hanno ; Hacker, Ulrich T. ; Heinemann, Volker ; Illert, Anna L. ; Keilholz, Ulrich ; Kindler, Thomas ; Kirschner, Martin ; Schilling, Bastian ; Siveke, Jens T. ; Schroeder, Thomas ; Tischler, Verena ; Wagner, Sebastian ; Weichert, Wilko ; Zips, Daniel ; Loges, Sonja ; Bargou (Würzburg), Ralf ; Bläker (Leipzig), Hendrik ; Börries (Freiburg), Melanie ; Brandts (Frankfurt), Christian ; von Bubnoff (Lübeck), Nikolas ; Demes (Frankfurt), Melanie ; Desuki (Mainz), Alexander ; Döhner (Ulm), Hartmut ; Duyster (Freiburg), Justus ; Gaisa (Aachen), Nadine ; Heine (Bonn), Annkristin ; Heining (Dresden), Christoph ; Horak (Heidelberg), Peter ; Jelas (Berlin), Ivan ; Jost (München), Philipp J. ; Jung (München), Andreas ; Kirchner (München), Thomas ; Klauschen (Berlin), Frederick ; Kreutzfeldt (Heidelberg), Simon ; Kumbrink (München), Jörg ; Kunzmann (Würzburg), Volker ; Lassmann (Freiburg), Silke ; Metzeler (München), Klaus ; Möller (Ulm), Peter ; Ortiz-Brüchle (Aachen), Nadina ; Paret (Mainz), Claudia ; Pelusi (Bonn), Natalie ; Peters (Freiburg), Christoph ; Pfarr (München), Nicole ; Richter (Dresden), Daniela ; Riedmann (München), Kristina ; Rieke (Berlin), Damian ; Ritzel (Mainz), Christoph ; Schadendorf (Essen), Dirk ; Schildhaus (Essen), Hans-Ulrich ; Schorle (Bonn), Hubert ; Seufferlein (Ulm), Thomas ; Simon (Hamburg), Ronald ; Stenzinger (Heidelberg), Albrecht ; Tabatabai (Tübingen), Ghazaleh ; Velthaus (Hamburg), Janna-Lisa ; Werner (Freiburg), Martin ; Wild (Frankfurt), Peter J. ; Wolf (Köln), Jürgen</creator><creatorcontrib>Westphalen, C. Benedikt ; Bokemeyer, Carsten ; Büttner, Reinhard ; Fröhling, Stefan ; Gaidzik, Verena I. ; Glimm, Hanno ; Hacker, Ulrich T. ; Heinemann, Volker ; Illert, Anna L. ; Keilholz, Ulrich ; Kindler, Thomas ; Kirschner, Martin ; Schilling, Bastian ; Siveke, Jens T. ; Schroeder, Thomas ; Tischler, Verena ; Wagner, Sebastian ; Weichert, Wilko ; Zips, Daniel ; Loges, Sonja ; Bargou (Würzburg), Ralf ; Bläker (Leipzig), Hendrik ; Börries (Freiburg), Melanie ; Brandts (Frankfurt), Christian ; von Bubnoff (Lübeck), Nikolas ; Demes (Frankfurt), Melanie ; Desuki (Mainz), Alexander ; Döhner (Ulm), Hartmut ; Duyster (Freiburg), Justus ; Gaisa (Aachen), Nadine ; Heine (Bonn), Annkristin ; Heining (Dresden), Christoph ; Horak (Heidelberg), Peter ; Jelas (Berlin), Ivan ; Jost (München), Philipp J. ; Jung (München), Andreas ; Kirchner (München), Thomas ; Klauschen (Berlin), Frederick ; Kreutzfeldt (Heidelberg), Simon ; Kumbrink (München), Jörg ; Kunzmann (Würzburg), Volker ; Lassmann (Freiburg), Silke ; Metzeler (München), Klaus ; Möller (Ulm), Peter ; Ortiz-Brüchle (Aachen), Nadina ; Paret (Mainz), Claudia ; Pelusi (Bonn), Natalie ; Peters (Freiburg), Christoph ; Pfarr (München), Nicole ; Richter (Dresden), Daniela ; Riedmann (München), Kristina ; Rieke (Berlin), Damian ; Ritzel (Mainz), Christoph ; Schadendorf (Essen), Dirk ; Schildhaus (Essen), Hans-Ulrich ; Schorle (Bonn), Hubert ; Seufferlein (Ulm), Thomas ; Simon (Hamburg), Ronald ; Stenzinger (Heidelberg), Albrecht ; Tabatabai (Tübingen), Ghazaleh ; Velthaus (Hamburg), Janna-Lisa ; Werner (Freiburg), Martin ; Wild (Frankfurt), Peter J. ; Wolf (Köln), Jürgen ; Working Group Molecular Diagnostics and Therapy</creatorcontrib><description>Precision cancer medicine (PCM) holds great promises to offer more effective therapies to patients based on molecular profiling of their individual tumours. Although the PCM approach seems intuitive, multiple conceptional and structural challenges interfere with the broad implementation of PCM into clinical practice. Accordingly, concerted national and international efforts are needed to guide the further development and broad adoption of PCM in Germany. With support of the ‘German Cancer Aid’ (Deutsche Krebshilfe [DKH]) a task force ‘Molecular Diagnostics and Therapy’ was implemented. In two workshops supported by the DKH, delegates from the fourteen comprehensive cancer centresidentified key topics essential to implement quality-guided, harmonized and adaptable PCM. Based on an online questionnaire and using a modified Delphi approach, nine statements were drafted and evaluated within the group. These statements could serve as a basis to define a collaborative strategy for PCM in the future with the aim to sustain and further improve its quality.
•This consenus statement originated from collaborative efforts of all fourteen Comprehensive Cancer Centres in the German Cancer Aid network.•The consensus statement is based on all centres' consent due to implementation of a modified Delphi process.•This consensus statement will serve as a framework to establish sustainable structures for precision cancer medicine in Germany.</description><identifier>ISSN: 0959-8049</identifier><identifier>EISSN: 1879-0852</identifier><identifier>DOI: 10.1016/j.ejca.2020.04.019</identifier><identifier>PMID: 32521293</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Antineoplastic Agents - therapeutic use ; Consensus ; Delphi Technique ; Genomic profiling ; Germany ; Humans ; Molecular Diagnostic Techniques - standards ; Molecular diagnostics ; Molecular Targeted Therapy - standards ; Molecular tumour board ; Neoplasms - diagnosis ; Neoplasms - genetics ; Neoplasms - therapy ; Precision medicine ; Precision Medicine - standards ; Precision oncology ; Predictive Value of Tests ; Research Design - standards</subject><ispartof>European journal of cancer (1990), 2020-08, Vol.135, p.1-7</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-e0b50b135c171a875bab3168d90773a6cd15b20d3119e58cd1de96f936d15d7f3</citedby><cites>FETCH-LOGICAL-c356t-e0b50b135c171a875bab3168d90773a6cd15b20d3119e58cd1de96f936d15d7f3</cites><orcidid>0000-0002-8629-6310 ; 0000-0002-5310-3754 ; 0000-0002-8772-4778</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0959804920302227$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32521293$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Westphalen, C. Benedikt</creatorcontrib><creatorcontrib>Bokemeyer, Carsten</creatorcontrib><creatorcontrib>Büttner, Reinhard</creatorcontrib><creatorcontrib>Fröhling, Stefan</creatorcontrib><creatorcontrib>Gaidzik, Verena I.</creatorcontrib><creatorcontrib>Glimm, Hanno</creatorcontrib><creatorcontrib>Hacker, Ulrich T.</creatorcontrib><creatorcontrib>Heinemann, Volker</creatorcontrib><creatorcontrib>Illert, Anna L.</creatorcontrib><creatorcontrib>Keilholz, Ulrich</creatorcontrib><creatorcontrib>Kindler, Thomas</creatorcontrib><creatorcontrib>Kirschner, Martin</creatorcontrib><creatorcontrib>Schilling, Bastian</creatorcontrib><creatorcontrib>Siveke, Jens T.</creatorcontrib><creatorcontrib>Schroeder, Thomas</creatorcontrib><creatorcontrib>Tischler, Verena</creatorcontrib><creatorcontrib>Wagner, Sebastian</creatorcontrib><creatorcontrib>Weichert, Wilko</creatorcontrib><creatorcontrib>Zips, Daniel</creatorcontrib><creatorcontrib>Loges, Sonja</creatorcontrib><creatorcontrib>Bargou (Würzburg), Ralf</creatorcontrib><creatorcontrib>Bläker (Leipzig), Hendrik</creatorcontrib><creatorcontrib>Börries (Freiburg), Melanie</creatorcontrib><creatorcontrib>Brandts (Frankfurt), Christian</creatorcontrib><creatorcontrib>von Bubnoff (Lübeck), Nikolas</creatorcontrib><creatorcontrib>Demes (Frankfurt), Melanie</creatorcontrib><creatorcontrib>Desuki (Mainz), Alexander</creatorcontrib><creatorcontrib>Döhner (Ulm), Hartmut</creatorcontrib><creatorcontrib>Duyster (Freiburg), Justus</creatorcontrib><creatorcontrib>Gaisa (Aachen), Nadine</creatorcontrib><creatorcontrib>Heine (Bonn), Annkristin</creatorcontrib><creatorcontrib>Heining (Dresden), Christoph</creatorcontrib><creatorcontrib>Horak (Heidelberg), Peter</creatorcontrib><creatorcontrib>Jelas (Berlin), Ivan</creatorcontrib><creatorcontrib>Jost (München), Philipp J.</creatorcontrib><creatorcontrib>Jung (München), Andreas</creatorcontrib><creatorcontrib>Kirchner (München), Thomas</creatorcontrib><creatorcontrib>Klauschen (Berlin), Frederick</creatorcontrib><creatorcontrib>Kreutzfeldt (Heidelberg), Simon</creatorcontrib><creatorcontrib>Kumbrink (München), Jörg</creatorcontrib><creatorcontrib>Kunzmann (Würzburg), Volker</creatorcontrib><creatorcontrib>Lassmann (Freiburg), Silke</creatorcontrib><creatorcontrib>Metzeler (München), Klaus</creatorcontrib><creatorcontrib>Möller (Ulm), Peter</creatorcontrib><creatorcontrib>Ortiz-Brüchle (Aachen), Nadina</creatorcontrib><creatorcontrib>Paret (Mainz), Claudia</creatorcontrib><creatorcontrib>Pelusi (Bonn), Natalie</creatorcontrib><creatorcontrib>Peters (Freiburg), Christoph</creatorcontrib><creatorcontrib>Pfarr (München), Nicole</creatorcontrib><creatorcontrib>Richter (Dresden), Daniela</creatorcontrib><creatorcontrib>Riedmann (München), Kristina</creatorcontrib><creatorcontrib>Rieke (Berlin), Damian</creatorcontrib><creatorcontrib>Ritzel (Mainz), Christoph</creatorcontrib><creatorcontrib>Schadendorf (Essen), Dirk</creatorcontrib><creatorcontrib>Schildhaus (Essen), Hans-Ulrich</creatorcontrib><creatorcontrib>Schorle (Bonn), Hubert</creatorcontrib><creatorcontrib>Seufferlein (Ulm), Thomas</creatorcontrib><creatorcontrib>Simon (Hamburg), Ronald</creatorcontrib><creatorcontrib>Stenzinger (Heidelberg), Albrecht</creatorcontrib><creatorcontrib>Tabatabai (Tübingen), Ghazaleh</creatorcontrib><creatorcontrib>Velthaus (Hamburg), Janna-Lisa</creatorcontrib><creatorcontrib>Werner (Freiburg), Martin</creatorcontrib><creatorcontrib>Wild (Frankfurt), Peter J.</creatorcontrib><creatorcontrib>Wolf (Köln), Jürgen</creatorcontrib><creatorcontrib>Working Group Molecular Diagnostics and Therapy</creatorcontrib><title>Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group ‘Molecular Diagnostics and Therapy’</title><title>European journal of cancer (1990)</title><addtitle>Eur J Cancer</addtitle><description>Precision cancer medicine (PCM) holds great promises to offer more effective therapies to patients based on molecular profiling of their individual tumours. Although the PCM approach seems intuitive, multiple conceptional and structural challenges interfere with the broad implementation of PCM into clinical practice. Accordingly, concerted national and international efforts are needed to guide the further development and broad adoption of PCM in Germany. With support of the ‘German Cancer Aid’ (Deutsche Krebshilfe [DKH]) a task force ‘Molecular Diagnostics and Therapy’ was implemented. In two workshops supported by the DKH, delegates from the fourteen comprehensive cancer centresidentified key topics essential to implement quality-guided, harmonized and adaptable PCM. Based on an online questionnaire and using a modified Delphi approach, nine statements were drafted and evaluated within the group. These statements could serve as a basis to define a collaborative strategy for PCM in the future with the aim to sustain and further improve its quality.
•This consenus statement originated from collaborative efforts of all fourteen Comprehensive Cancer Centres in the German Cancer Aid network.•The consensus statement is based on all centres' consent due to implementation of a modified Delphi process.•This consensus statement will serve as a framework to establish sustainable structures for precision cancer medicine in Germany.</description><subject>Antineoplastic Agents - therapeutic use</subject><subject>Consensus</subject><subject>Delphi Technique</subject><subject>Genomic profiling</subject><subject>Germany</subject><subject>Humans</subject><subject>Molecular Diagnostic Techniques - standards</subject><subject>Molecular diagnostics</subject><subject>Molecular Targeted Therapy - standards</subject><subject>Molecular tumour board</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - therapy</subject><subject>Precision medicine</subject><subject>Precision Medicine - standards</subject><subject>Precision oncology</subject><subject>Predictive Value of Tests</subject><subject>Research Design - standards</subject><issn>0959-8049</issn><issn>1879-0852</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAURS0EokPhB1ggL9kkPDvjJEZs0BQKoohNWVuO8zLjIbGD7RTNrp8Ba_6sX4JHU1iysi2fe6X3DiHPGZQMWP1qX-Le6JIDhxLWJTD5gKxY28gCWsEfkhVIIYsW1vKMPIlxDwBNu4bH5KzigjMuqxX5vfHO4JwWPdIh6Al_-PCNDj7QOaCx0XpHjc5IoBP21liH1Dp6iWHS7vCa5nhEF5dIY9IJJ3SJ-oGmHdILXFI0-fIpYBd3dhyQHtut29Jt8MtM725_fvYjmmXUgV5YvXU-Jmsi1a6n1zsMej7c3f56Sh4Neoz47P48J1_fv7vefCiuvlx-3Ly9Kkwl6lQgdAI6VgnDGqbbRnS6q1jd9hKaptK16ZnoOPQVYxJFm589ynqQVZ0_-maozsnLU-8c_PcFY1KTjQbHUTv0S1R8zTjnIKTIKD-hJvgYAw5qDnbS4aAYqKMctVdHOeooR8FaZTk59OK-f-nyMv9F_trIwJsTgHnKG4tBRWMxL7-3WUZSvbf_6_8Dzp2ljw</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>Westphalen, C. Benedikt</creator><creator>Bokemeyer, Carsten</creator><creator>Büttner, Reinhard</creator><creator>Fröhling, Stefan</creator><creator>Gaidzik, Verena I.</creator><creator>Glimm, Hanno</creator><creator>Hacker, Ulrich T.</creator><creator>Heinemann, Volker</creator><creator>Illert, Anna L.</creator><creator>Keilholz, Ulrich</creator><creator>Kindler, Thomas</creator><creator>Kirschner, Martin</creator><creator>Schilling, Bastian</creator><creator>Siveke, Jens T.</creator><creator>Schroeder, Thomas</creator><creator>Tischler, Verena</creator><creator>Wagner, Sebastian</creator><creator>Weichert, Wilko</creator><creator>Zips, Daniel</creator><creator>Loges, Sonja</creator><creator>Bargou (Würzburg), Ralf</creator><creator>Bläker (Leipzig), Hendrik</creator><creator>Börries (Freiburg), Melanie</creator><creator>Brandts (Frankfurt), Christian</creator><creator>von Bubnoff (Lübeck), Nikolas</creator><creator>Demes (Frankfurt), Melanie</creator><creator>Desuki (Mainz), Alexander</creator><creator>Döhner (Ulm), Hartmut</creator><creator>Duyster (Freiburg), Justus</creator><creator>Gaisa (Aachen), Nadine</creator><creator>Heine (Bonn), Annkristin</creator><creator>Heining (Dresden), Christoph</creator><creator>Horak (Heidelberg), Peter</creator><creator>Jelas (Berlin), Ivan</creator><creator>Jost (München), Philipp J.</creator><creator>Jung (München), Andreas</creator><creator>Kirchner (München), Thomas</creator><creator>Klauschen (Berlin), Frederick</creator><creator>Kreutzfeldt (Heidelberg), Simon</creator><creator>Kumbrink (München), Jörg</creator><creator>Kunzmann (Würzburg), Volker</creator><creator>Lassmann (Freiburg), Silke</creator><creator>Metzeler (München), Klaus</creator><creator>Möller (Ulm), Peter</creator><creator>Ortiz-Brüchle (Aachen), Nadina</creator><creator>Paret (Mainz), Claudia</creator><creator>Pelusi (Bonn), Natalie</creator><creator>Peters (Freiburg), Christoph</creator><creator>Pfarr (München), Nicole</creator><creator>Richter (Dresden), Daniela</creator><creator>Riedmann (München), Kristina</creator><creator>Rieke (Berlin), Damian</creator><creator>Ritzel (Mainz), Christoph</creator><creator>Schadendorf (Essen), Dirk</creator><creator>Schildhaus (Essen), Hans-Ulrich</creator><creator>Schorle (Bonn), Hubert</creator><creator>Seufferlein (Ulm), Thomas</creator><creator>Simon (Hamburg), Ronald</creator><creator>Stenzinger (Heidelberg), Albrecht</creator><creator>Tabatabai (Tübingen), Ghazaleh</creator><creator>Velthaus (Hamburg), Janna-Lisa</creator><creator>Werner (Freiburg), Martin</creator><creator>Wild (Frankfurt), Peter J.</creator><creator>Wolf (Köln), Jürgen</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8629-6310</orcidid><orcidid>https://orcid.org/0000-0002-5310-3754</orcidid><orcidid>https://orcid.org/0000-0002-8772-4778</orcidid></search><sort><creationdate>202008</creationdate><title>Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group ‘Molecular Diagnostics and Therapy’</title><author>Westphalen, C. Benedikt ; Bokemeyer, Carsten ; Büttner, Reinhard ; Fröhling, Stefan ; Gaidzik, Verena I. ; Glimm, Hanno ; Hacker, Ulrich T. ; Heinemann, Volker ; Illert, Anna L. ; Keilholz, Ulrich ; Kindler, Thomas ; Kirschner, Martin ; Schilling, Bastian ; Siveke, Jens T. ; Schroeder, Thomas ; Tischler, Verena ; Wagner, Sebastian ; Weichert, Wilko ; Zips, Daniel ; Loges, Sonja ; Bargou (Würzburg), Ralf ; Bläker (Leipzig), Hendrik ; Börries (Freiburg), Melanie ; Brandts (Frankfurt), Christian ; von Bubnoff (Lübeck), Nikolas ; Demes (Frankfurt), Melanie ; Desuki (Mainz), Alexander ; Döhner (Ulm), Hartmut ; Duyster (Freiburg), Justus ; Gaisa (Aachen), Nadine ; Heine (Bonn), Annkristin ; Heining (Dresden), Christoph ; Horak (Heidelberg), Peter ; Jelas (Berlin), Ivan ; Jost (München), Philipp J. ; Jung (München), Andreas ; Kirchner (München), Thomas ; Klauschen (Berlin), Frederick ; Kreutzfeldt (Heidelberg), Simon ; Kumbrink (München), Jörg ; Kunzmann (Würzburg), Volker ; Lassmann (Freiburg), Silke ; Metzeler (München), Klaus ; Möller (Ulm), Peter ; Ortiz-Brüchle (Aachen), Nadina ; Paret (Mainz), Claudia ; Pelusi (Bonn), Natalie ; Peters (Freiburg), Christoph ; Pfarr (München), Nicole ; Richter (Dresden), Daniela ; Riedmann (München), Kristina ; Rieke (Berlin), Damian ; Ritzel (Mainz), Christoph ; Schadendorf (Essen), Dirk ; Schildhaus (Essen), Hans-Ulrich ; Schorle (Bonn), Hubert ; Seufferlein (Ulm), Thomas ; Simon (Hamburg), Ronald ; Stenzinger (Heidelberg), Albrecht ; Tabatabai (Tübingen), Ghazaleh ; Velthaus (Hamburg), Janna-Lisa ; Werner (Freiburg), Martin ; Wild (Frankfurt), Peter J. ; Wolf (Köln), Jürgen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-e0b50b135c171a875bab3168d90773a6cd15b20d3119e58cd1de96f936d15d7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antineoplastic Agents - therapeutic use</topic><topic>Consensus</topic><topic>Delphi Technique</topic><topic>Genomic profiling</topic><topic>Germany</topic><topic>Humans</topic><topic>Molecular Diagnostic Techniques - standards</topic><topic>Molecular diagnostics</topic><topic>Molecular Targeted Therapy - standards</topic><topic>Molecular tumour board</topic><topic>Neoplasms - diagnosis</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - therapy</topic><topic>Precision medicine</topic><topic>Precision Medicine - standards</topic><topic>Precision oncology</topic><topic>Predictive Value of Tests</topic><topic>Research Design - standards</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Westphalen, C. Benedikt</creatorcontrib><creatorcontrib>Bokemeyer, Carsten</creatorcontrib><creatorcontrib>Büttner, Reinhard</creatorcontrib><creatorcontrib>Fröhling, Stefan</creatorcontrib><creatorcontrib>Gaidzik, Verena I.</creatorcontrib><creatorcontrib>Glimm, Hanno</creatorcontrib><creatorcontrib>Hacker, Ulrich T.</creatorcontrib><creatorcontrib>Heinemann, Volker</creatorcontrib><creatorcontrib>Illert, Anna L.</creatorcontrib><creatorcontrib>Keilholz, Ulrich</creatorcontrib><creatorcontrib>Kindler, Thomas</creatorcontrib><creatorcontrib>Kirschner, Martin</creatorcontrib><creatorcontrib>Schilling, Bastian</creatorcontrib><creatorcontrib>Siveke, Jens T.</creatorcontrib><creatorcontrib>Schroeder, Thomas</creatorcontrib><creatorcontrib>Tischler, Verena</creatorcontrib><creatorcontrib>Wagner, Sebastian</creatorcontrib><creatorcontrib>Weichert, Wilko</creatorcontrib><creatorcontrib>Zips, Daniel</creatorcontrib><creatorcontrib>Loges, Sonja</creatorcontrib><creatorcontrib>Bargou (Würzburg), Ralf</creatorcontrib><creatorcontrib>Bläker (Leipzig), Hendrik</creatorcontrib><creatorcontrib>Börries (Freiburg), Melanie</creatorcontrib><creatorcontrib>Brandts (Frankfurt), Christian</creatorcontrib><creatorcontrib>von Bubnoff (Lübeck), Nikolas</creatorcontrib><creatorcontrib>Demes (Frankfurt), Melanie</creatorcontrib><creatorcontrib>Desuki (Mainz), Alexander</creatorcontrib><creatorcontrib>Döhner (Ulm), Hartmut</creatorcontrib><creatorcontrib>Duyster (Freiburg), Justus</creatorcontrib><creatorcontrib>Gaisa (Aachen), Nadine</creatorcontrib><creatorcontrib>Heine (Bonn), Annkristin</creatorcontrib><creatorcontrib>Heining (Dresden), Christoph</creatorcontrib><creatorcontrib>Horak (Heidelberg), Peter</creatorcontrib><creatorcontrib>Jelas (Berlin), Ivan</creatorcontrib><creatorcontrib>Jost (München), Philipp J.</creatorcontrib><creatorcontrib>Jung (München), Andreas</creatorcontrib><creatorcontrib>Kirchner (München), Thomas</creatorcontrib><creatorcontrib>Klauschen (Berlin), Frederick</creatorcontrib><creatorcontrib>Kreutzfeldt (Heidelberg), Simon</creatorcontrib><creatorcontrib>Kumbrink (München), Jörg</creatorcontrib><creatorcontrib>Kunzmann (Würzburg), Volker</creatorcontrib><creatorcontrib>Lassmann (Freiburg), Silke</creatorcontrib><creatorcontrib>Metzeler (München), Klaus</creatorcontrib><creatorcontrib>Möller (Ulm), Peter</creatorcontrib><creatorcontrib>Ortiz-Brüchle (Aachen), Nadina</creatorcontrib><creatorcontrib>Paret (Mainz), Claudia</creatorcontrib><creatorcontrib>Pelusi (Bonn), Natalie</creatorcontrib><creatorcontrib>Peters (Freiburg), Christoph</creatorcontrib><creatorcontrib>Pfarr (München), Nicole</creatorcontrib><creatorcontrib>Richter (Dresden), Daniela</creatorcontrib><creatorcontrib>Riedmann (München), Kristina</creatorcontrib><creatorcontrib>Rieke (Berlin), Damian</creatorcontrib><creatorcontrib>Ritzel (Mainz), Christoph</creatorcontrib><creatorcontrib>Schadendorf (Essen), Dirk</creatorcontrib><creatorcontrib>Schildhaus (Essen), Hans-Ulrich</creatorcontrib><creatorcontrib>Schorle (Bonn), Hubert</creatorcontrib><creatorcontrib>Seufferlein (Ulm), Thomas</creatorcontrib><creatorcontrib>Simon (Hamburg), Ronald</creatorcontrib><creatorcontrib>Stenzinger (Heidelberg), Albrecht</creatorcontrib><creatorcontrib>Tabatabai (Tübingen), Ghazaleh</creatorcontrib><creatorcontrib>Velthaus (Hamburg), Janna-Lisa</creatorcontrib><creatorcontrib>Werner (Freiburg), Martin</creatorcontrib><creatorcontrib>Wild (Frankfurt), Peter J.</creatorcontrib><creatorcontrib>Wolf (Köln), Jürgen</creatorcontrib><creatorcontrib>Working Group Molecular Diagnostics and Therapy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cancer (1990)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Westphalen, C. Benedikt</au><au>Bokemeyer, Carsten</au><au>Büttner, Reinhard</au><au>Fröhling, Stefan</au><au>Gaidzik, Verena I.</au><au>Glimm, Hanno</au><au>Hacker, Ulrich T.</au><au>Heinemann, Volker</au><au>Illert, Anna L.</au><au>Keilholz, Ulrich</au><au>Kindler, Thomas</au><au>Kirschner, Martin</au><au>Schilling, Bastian</au><au>Siveke, Jens T.</au><au>Schroeder, Thomas</au><au>Tischler, Verena</au><au>Wagner, Sebastian</au><au>Weichert, Wilko</au><au>Zips, Daniel</au><au>Loges, Sonja</au><au>Bargou (Würzburg), Ralf</au><au>Bläker (Leipzig), Hendrik</au><au>Börries (Freiburg), Melanie</au><au>Brandts (Frankfurt), Christian</au><au>von Bubnoff (Lübeck), Nikolas</au><au>Demes (Frankfurt), Melanie</au><au>Desuki (Mainz), Alexander</au><au>Döhner (Ulm), Hartmut</au><au>Duyster (Freiburg), Justus</au><au>Gaisa (Aachen), Nadine</au><au>Heine (Bonn), Annkristin</au><au>Heining (Dresden), Christoph</au><au>Horak (Heidelberg), Peter</au><au>Jelas (Berlin), Ivan</au><au>Jost (München), Philipp J.</au><au>Jung (München), Andreas</au><au>Kirchner (München), Thomas</au><au>Klauschen (Berlin), Frederick</au><au>Kreutzfeldt (Heidelberg), Simon</au><au>Kumbrink (München), Jörg</au><au>Kunzmann (Würzburg), Volker</au><au>Lassmann (Freiburg), Silke</au><au>Metzeler (München), Klaus</au><au>Möller (Ulm), Peter</au><au>Ortiz-Brüchle (Aachen), Nadina</au><au>Paret (Mainz), Claudia</au><au>Pelusi (Bonn), Natalie</au><au>Peters (Freiburg), Christoph</au><au>Pfarr (München), Nicole</au><au>Richter (Dresden), Daniela</au><au>Riedmann (München), Kristina</au><au>Rieke (Berlin), Damian</au><au>Ritzel (Mainz), Christoph</au><au>Schadendorf (Essen), Dirk</au><au>Schildhaus (Essen), Hans-Ulrich</au><au>Schorle (Bonn), Hubert</au><au>Seufferlein (Ulm), Thomas</au><au>Simon (Hamburg), Ronald</au><au>Stenzinger (Heidelberg), Albrecht</au><au>Tabatabai (Tübingen), Ghazaleh</au><au>Velthaus (Hamburg), Janna-Lisa</au><au>Werner (Freiburg), Martin</au><au>Wild (Frankfurt), Peter J.</au><au>Wolf (Köln), Jürgen</au><aucorp>Working Group Molecular Diagnostics and Therapy</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group ‘Molecular Diagnostics and Therapy’</atitle><jtitle>European journal of cancer (1990)</jtitle><addtitle>Eur J Cancer</addtitle><date>2020-08</date><risdate>2020</risdate><volume>135</volume><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>0959-8049</issn><eissn>1879-0852</eissn><abstract>Precision cancer medicine (PCM) holds great promises to offer more effective therapies to patients based on molecular profiling of their individual tumours. Although the PCM approach seems intuitive, multiple conceptional and structural challenges interfere with the broad implementation of PCM into clinical practice. Accordingly, concerted national and international efforts are needed to guide the further development and broad adoption of PCM in Germany. With support of the ‘German Cancer Aid’ (Deutsche Krebshilfe [DKH]) a task force ‘Molecular Diagnostics and Therapy’ was implemented. In two workshops supported by the DKH, delegates from the fourteen comprehensive cancer centresidentified key topics essential to implement quality-guided, harmonized and adaptable PCM. Based on an online questionnaire and using a modified Delphi approach, nine statements were drafted and evaluated within the group. These statements could serve as a basis to define a collaborative strategy for PCM in the future with the aim to sustain and further improve its quality.
•This consenus statement originated from collaborative efforts of all fourteen Comprehensive Cancer Centres in the German Cancer Aid network.•The consensus statement is based on all centres' consent due to implementation of a modified Delphi process.•This consensus statement will serve as a framework to establish sustainable structures for precision cancer medicine in Germany.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>32521293</pmid><doi>10.1016/j.ejca.2020.04.019</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8629-6310</orcidid><orcidid>https://orcid.org/0000-0002-5310-3754</orcidid><orcidid>https://orcid.org/0000-0002-8772-4778</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-8049 |
| ispartof | European journal of cancer (1990), 2020-08, Vol.135, p.1-7 |
| issn | 0959-8049 1879-0852 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2412220595 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antineoplastic Agents - therapeutic use Consensus Delphi Technique Genomic profiling Germany Humans Molecular Diagnostic Techniques - standards Molecular diagnostics Molecular Targeted Therapy - standards Molecular tumour board Neoplasms - diagnosis Neoplasms - genetics Neoplasms - therapy Precision medicine Precision Medicine - standards Precision oncology Predictive Value of Tests Research Design - standards |
| title | Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group ‘Molecular Diagnostics and Therapy’ |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T02%3A31%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Conceptual%20framework%20for%20precision%20cancer%20medicine%20in%20Germany:%20Consensus%20statement%20of%20the%20Deutsche%20Krebshilfe%20working%20group%20%E2%80%98Molecular%20Diagnostics%20and%20Therapy%E2%80%99&rft.jtitle=European%20journal%20of%20cancer%20(1990)&rft.au=Westphalen,%20C.%20Benedikt&rft.aucorp=Working%20Group%20Molecular%20Diagnostics%20and%20Therapy&rft.date=2020-08&rft.volume=135&rft.spage=1&rft.epage=7&rft.pages=1-7&rft.issn=0959-8049&rft.eissn=1879-0852&rft_id=info:doi/10.1016/j.ejca.2020.04.019&rft_dat=%3Cproquest_cross%3E2412220595%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2412220595&rft_id=info:pmid/32521293&rft_els_id=S0959804920302227&rfr_iscdi=true |