Antiproliferative Flavanoid Dimers Isolated from Brazilian Red Propolis

Antiproliferative Flavanoid Dimers Isolated from Brazilian Red Propolis

Herein reported are results of the chemical and biological investigation of red propolis collected at the Brazilian Northeast coastline. New propolones A–D (1–4), with a 3-{3-[(2-phenyl­benzo­furan-3-yl)­methyl]­phenyl}­chromane skeleton; propolonones A–C (5–7), with a 3-[3-(3-benzyl­benzo­furan-2-y...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2020-06, Vol.83 (6), p.1784-1793
Hauptverfasser: Banzato, Thais P, Gubiani, Juliana R, Bernardi, Darlon I, Nogueira, Cláudio R, Monteiro, Afif F, Juliano, Fernanda F, de Alencar, Severino M, Pilli, Ronaldo A, Lima, Carolina A. de, Longato, Giovanna B, Ferreira, Antonio G, Foglio, Mary Ann, Carvalho, João E. de, Vendramini-Costa, Débora B, Berlinck, Roberto G. S
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container_end_page 1793
container_issue 6
container_start_page 1784
container_title Journal of natural products (Washington, D.C.)
container_volume 83
creator Banzato, Thais P
Gubiani, Juliana R
Bernardi, Darlon I
Nogueira, Cláudio R
Monteiro, Afif F
Juliano, Fernanda F
de Alencar, Severino M
Pilli, Ronaldo A
Lima, Carolina A. de
Longato, Giovanna B
Ferreira, Antonio G
Foglio, Mary Ann
Carvalho, João E. de
Vendramini-Costa, Débora B
Berlinck, Roberto G. S
description Herein reported are results of the chemical and biological investigation of red propolis collected at the Brazilian Northeast coastline. New propolones A–D (1–4), with a 3-{3-[(2-phenyl­benzo­furan-3-yl)­methyl]­phenyl}­chromane skeleton; propolonones A–C (5–7), with a 3-[3-(3-benzyl­benzo­furan-2-yl)­phenyl]­chromane skeleton; and propolol A (8), with a 6-(3-benzyl­benzofuran-2-yl)-3-phenyl­chromane skeleton, were isolated as constituents of Brazilian red propolis by cytotoxicity-guided assays and structurally identified by analysis of their spectroscopic data. Propolone B (2) and propolonone A (5) display significant cytotoxic activities against an ovarian cancer cell line expressing a multiple drug resistance phenotype when compared with doxorubicin.
doi_str_mv 10.1021/acs.jnatprod.9b01136
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title Antiproliferative Flavanoid Dimers Isolated from Brazilian Red Propolis
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