Disulphide-mediated site-directed modification of proteins

Methods for chemical modification of native proteins in a controlled fashion are in high demand. Here, a novel protocol that exploits bifunctional reagents for transient targeting of solvent exposed disulphides to direct the introduction of a single exogenous reactive thiol handle at a lysine side c...

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Veröffentlicht in:	Organic & biomolecular chemistry 2020-07, Vol.18 (25), p.4717-4722
Hauptverfasser:	Nielsen, Thorbjørn, Märcher, Anders, Drob áková, Zuzana, Hu ko, Michal, Štengl, Milan, Balšánek, Vojt ch, Wiberg, Charlotte, Nielsen, Per F, Nielsen, Thomas E, Gothelf, Kurt V, Cló, Emiliano
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical modification Disulfides Growth hormones Lysine Proteins Reagents
Online-Zugang:	Volltext
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