Chemogenetic Inhibition of Dopaminergic Projections to the Nucleus Accumbens Has Sexually Dimorphic Effects in the Rat Gambling Task

Women and men can differ in their propensity to take risks and develop impulse control and addiction disorders. Sexual dimorphisms in behavioral control by the mesolimbic dopaminergic reward system may underlie these phenomena, given its sensitivity to gonadal hormones. However, this is hard to test...

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Veröffentlicht in:	Behavioral neuroscience 2020-08, Vol.134 (4), p.309-322
Hauptverfasser:	Hynes, Tristan J., Ferland, Jacqueline-Marie M., Feng, Tanya L., Adams, Wendy K., Silveira, Mason M., Tremblay, Melanie, Chernoff, Chloe S., Brodie, Hannah G., Ebsary, Sophie A., Russell, Brittney, Kaur, Sukhbir, Winstanley, Catharine A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Addiction Addictions Animal Animal Sex Differences Animals Behavior, Addictive - physiopathology Choice Behavior - physiology Clozapine Conditioning, Operant - drug effects Conditioning, Operant - physiology Cre recombinase Cues Decision Making Dopamine Dopamine - pharmacology Dopamine receptors Dopaminergic Neurons - drug effects Dopaminergic Neurons - physiology Female Females Gambling Gambling - physiopathology Gender Hydroxylase Impulsive behavior Impulsive Behavior - drug effects Impulsive Behavior - physiology Impulsiveness Impulsivity Male Males Mesolimbic system Neurons Nucleus Accumbens Nucleus Accumbens - drug effects Nucleus Accumbens - physiology Rats Rats, Long-Evans Rats, Transgenic Reinforcement Reward Risk Taking Sex Factors Sexual dimorphism Task Tyrosine 3-monooxygenase
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