Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer

Tumors are influenced by the mechanical properties of their microenvironment. Using patient samples and atomic force microscopy, we found that tissue stiffness is higher in liver metastases than in primary colorectal tumors. Highly activated metastasis-associated fibroblasts increase tissue stiffnes...

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Veröffentlicht in:	Cancer cell 2020-06, Vol.37 (6), p.800-817.e7
Hauptverfasser:	Shen, Ying, Wang, Xiaohong, Lu, Junyan, Salfenmoser, Martin, Wirsik, Naita Maren, Schleussner, Nikolai, Imle, Andrea, Freire Valls, Aida, Radhakrishnan, Praveen, Liang, Jie, Wang, Guoliang, Muley, Thomas, Schneider, Martin, Ruiz de Almodovar, Carmen, Diz-Muñoz, Alba, Schmidt, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	anti-angiogenic therapy atomic force microscopy bevacizumab CAFs fibroblasts MAFs metastatic colorectal cancer RAS signaling tissue stiffness
Online-Zugang:	Volltext
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