Does objectively measured light-intensity physical activity reduce the risk of cardiovascular mortality? A meta-analysis
Abstract Aims Current physical activity guidelines emphasize little on light-intensity physical activity (LPA) in terms of reducing the risk of cardiovascular mortality. This meta-analysis aimed to bridge this gap by assessing their association using objectively measured LPA data. Methods and result...
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| Veröffentlicht in: | European heart journal. Quality of care & clinical outcomes 2021-11, Vol.7 (5), p.496-504 |
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| container_title | European heart journal. Quality of care & clinical outcomes |
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| creator | Qiu, Shanhu Cai, Xue Jia, Lijing Sun, Zilin Wu, Tongzhi Wendt, Janine Steinacker, Jürgen Michael Schumann, Uwe |
| description | Abstract
Aims
Current physical activity guidelines emphasize little on light-intensity physical activity (LPA) in terms of reducing the risk of cardiovascular mortality. This meta-analysis aimed to bridge this gap by assessing their association using objectively measured LPA data.
Methods and results
Databases of PubMed and Scopus were searched to April 2020 for prospective cohort studies that reported the association of LPA assessed by activity monitors with the risk of cardiovascular mortality in the general population. Multivariable-adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled using a random-effects model. Dose–response and subgroup analyses were also performed. Six cohort studies with seven datasets enrolling 13 960 participants were included. LPA was all measured by accelerometers. The HR of LPA per 30 min/day for cardiovascular mortality was pooled to be 0.80 (95% CI 0.67–0.96). This association was non-linearly shaped (Pnonlinearity < 0.01) and unaffected by sex difference. Moreover, substituting LPA for sedentary time of 30 min/day lowered the risk of cardiovascular mortality by 16% (95% CI 0.73–0.96). Results showed further that LPA was inferior to moderate-to-vigorous physical activity in reducing the risk of cardiovascular mortality when performed with an equal time-length set at 30 min/day (HR 0.83 vs. 0.54, Pcomparison = 0.046), but became comparable if at an equal activity-amount set at 150 metabolic equivalents-min/day (HR 0.67 vs. 0.54, Pcomparison = 0.41).
Conclusion
LPA shows potential in reducing the risk of cardiovascular mortality, and interventions targeting at LPA improvement are worth being encouraged.
Graphical Abstract
Graphical Abstract |
| doi_str_mv | 10.1093/ehjqcco/qcaa051 |
| format | Article |
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Aims
Current physical activity guidelines emphasize little on light-intensity physical activity (LPA) in terms of reducing the risk of cardiovascular mortality. This meta-analysis aimed to bridge this gap by assessing their association using objectively measured LPA data.
Methods and results
Databases of PubMed and Scopus were searched to April 2020 for prospective cohort studies that reported the association of LPA assessed by activity monitors with the risk of cardiovascular mortality in the general population. Multivariable-adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled using a random-effects model. Dose–response and subgroup analyses were also performed. Six cohort studies with seven datasets enrolling 13 960 participants were included. LPA was all measured by accelerometers. The HR of LPA per 30 min/day for cardiovascular mortality was pooled to be 0.80 (95% CI 0.67–0.96). This association was non-linearly shaped (Pnonlinearity < 0.01) and unaffected by sex difference. Moreover, substituting LPA for sedentary time of 30 min/day lowered the risk of cardiovascular mortality by 16% (95% CI 0.73–0.96). Results showed further that LPA was inferior to moderate-to-vigorous physical activity in reducing the risk of cardiovascular mortality when performed with an equal time-length set at 30 min/day (HR 0.83 vs. 0.54, Pcomparison = 0.046), but became comparable if at an equal activity-amount set at 150 metabolic equivalents-min/day (HR 0.67 vs. 0.54, Pcomparison = 0.41).
Conclusion
LPA shows potential in reducing the risk of cardiovascular mortality, and interventions targeting at LPA improvement are worth being encouraged.
Graphical Abstract
Graphical Abstract</description><identifier>ISSN: 2058-5225</identifier><identifier>EISSN: 2058-1742</identifier><identifier>DOI: 10.1093/ehjqcco/qcaa051</identifier><identifier>PMID: 32514573</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Cardiovascular disease ; Cardiovascular Diseases - prevention & control ; Disease management ; Exercise ; Exercise - physiology ; Female ; Health risks ; Humans ; Male ; Meta-analysis ; Mortality ; Proportional Hazards Models ; Prospective Studies ; Sedentary Behavior</subject><ispartof>European heart journal. Quality of care & clinical outcomes, 2021-11, Vol.7 (5), p.496-504</ispartof><rights>Published on behalf of the European Society of Cardiology. 2020</rights><rights>Published on behalf of the European Society of Cardiology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-91e9646be8da39ca72c8614648053e39a274bbe20dcf34b630e0ab8dc5389d433</citedby><cites>FETCH-LOGICAL-c426t-91e9646be8da39ca72c8614648053e39a274bbe20dcf34b630e0ab8dc5389d433</cites><orcidid>0000-0003-2597-3856</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32514573$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qiu, Shanhu</creatorcontrib><creatorcontrib>Cai, Xue</creatorcontrib><creatorcontrib>Jia, Lijing</creatorcontrib><creatorcontrib>Sun, Zilin</creatorcontrib><creatorcontrib>Wu, Tongzhi</creatorcontrib><creatorcontrib>Wendt, Janine</creatorcontrib><creatorcontrib>Steinacker, Jürgen Michael</creatorcontrib><creatorcontrib>Schumann, Uwe</creatorcontrib><title>Does objectively measured light-intensity physical activity reduce the risk of cardiovascular mortality? A meta-analysis</title><title>European heart journal. Quality of care & clinical outcomes</title><addtitle>Eur Heart J Qual Care Clin Outcomes</addtitle><description>Abstract
Aims
Current physical activity guidelines emphasize little on light-intensity physical activity (LPA) in terms of reducing the risk of cardiovascular mortality. This meta-analysis aimed to bridge this gap by assessing their association using objectively measured LPA data.
Methods and results
Databases of PubMed and Scopus were searched to April 2020 for prospective cohort studies that reported the association of LPA assessed by activity monitors with the risk of cardiovascular mortality in the general population. Multivariable-adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled using a random-effects model. Dose–response and subgroup analyses were also performed. Six cohort studies with seven datasets enrolling 13 960 participants were included. LPA was all measured by accelerometers. The HR of LPA per 30 min/day for cardiovascular mortality was pooled to be 0.80 (95% CI 0.67–0.96). This association was non-linearly shaped (Pnonlinearity < 0.01) and unaffected by sex difference. Moreover, substituting LPA for sedentary time of 30 min/day lowered the risk of cardiovascular mortality by 16% (95% CI 0.73–0.96). Results showed further that LPA was inferior to moderate-to-vigorous physical activity in reducing the risk of cardiovascular mortality when performed with an equal time-length set at 30 min/day (HR 0.83 vs. 0.54, Pcomparison = 0.046), but became comparable if at an equal activity-amount set at 150 metabolic equivalents-min/day (HR 0.67 vs. 0.54, Pcomparison = 0.41).
Conclusion
LPA shows potential in reducing the risk of cardiovascular mortality, and interventions targeting at LPA improvement are worth being encouraged.
Graphical Abstract
Graphical Abstract</description><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>Disease management</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Female</subject><subject>Health risks</subject><subject>Humans</subject><subject>Male</subject><subject>Meta-analysis</subject><subject>Mortality</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Sedentary Behavior</subject><issn>2058-5225</issn><issn>2058-1742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqF0U1rGzEQBmBRUpqQ5txbEfQSChvre3dPJThfhUAv7XmZ1Y5ruVrLlrQh_veV8baHXnrSIJ55GXgJ-cDZDWetXOB6s7c2LPYWgGn-hlwIppuK10qczbMWQp-Tq5Q2jDFuZM25eUfOpdBc6VpekNe7gImGfoM2uxf0BzoipCniQL37uc6V22bcJpcPdLc-JGfBUzjS409Rk0Wa10ijS79oWFELcXDhBZKdPEQ6hpjBF_uF3pbkDBVswZec9J68XYFPeDW_l-THw_335VP1_O3x6_L2ubJKmFy1HFujTI_NALK1UAvbGK6MapiWKFsQtep7FGywK6l6Ixky6JvBatm0g5Lyklyfcncx7CdMuRtdsug9bDFMqROKc85My0Whn_6hmzDFcm9RujbG1K0xRS1OysaQUsRVt4tuhHjoOOuOvXRzL93cS9n4OOdO_YjDX_-nhQI-n0CYdv9N-w3hAJuP</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Qiu, Shanhu</creator><creator>Cai, Xue</creator><creator>Jia, Lijing</creator><creator>Sun, Zilin</creator><creator>Wu, Tongzhi</creator><creator>Wendt, Janine</creator><creator>Steinacker, Jürgen Michael</creator><creator>Schumann, Uwe</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2597-3856</orcidid></search><sort><creationdate>20211101</creationdate><title>Does objectively measured light-intensity physical activity reduce the risk of cardiovascular mortality? A meta-analysis</title><author>Qiu, Shanhu ; Cai, Xue ; Jia, Lijing ; Sun, Zilin ; Wu, Tongzhi ; Wendt, Janine ; Steinacker, Jürgen Michael ; Schumann, Uwe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-91e9646be8da39ca72c8614648053e39a274bbe20dcf34b630e0ab8dc5389d433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases - prevention & control</topic><topic>Disease management</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Female</topic><topic>Health risks</topic><topic>Humans</topic><topic>Male</topic><topic>Meta-analysis</topic><topic>Mortality</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Sedentary Behavior</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qiu, Shanhu</creatorcontrib><creatorcontrib>Cai, Xue</creatorcontrib><creatorcontrib>Jia, Lijing</creatorcontrib><creatorcontrib>Sun, Zilin</creatorcontrib><creatorcontrib>Wu, Tongzhi</creatorcontrib><creatorcontrib>Wendt, Janine</creatorcontrib><creatorcontrib>Steinacker, Jürgen Michael</creatorcontrib><creatorcontrib>Schumann, Uwe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal. Quality of care & clinical outcomes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qiu, Shanhu</au><au>Cai, Xue</au><au>Jia, Lijing</au><au>Sun, Zilin</au><au>Wu, Tongzhi</au><au>Wendt, Janine</au><au>Steinacker, Jürgen Michael</au><au>Schumann, Uwe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does objectively measured light-intensity physical activity reduce the risk of cardiovascular mortality? A meta-analysis</atitle><jtitle>European heart journal. Quality of care & clinical outcomes</jtitle><addtitle>Eur Heart J Qual Care Clin Outcomes</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>7</volume><issue>5</issue><spage>496</spage><epage>504</epage><pages>496-504</pages><issn>2058-5225</issn><eissn>2058-1742</eissn><abstract>Abstract
Aims
Current physical activity guidelines emphasize little on light-intensity physical activity (LPA) in terms of reducing the risk of cardiovascular mortality. This meta-analysis aimed to bridge this gap by assessing their association using objectively measured LPA data.
Methods and results
Databases of PubMed and Scopus were searched to April 2020 for prospective cohort studies that reported the association of LPA assessed by activity monitors with the risk of cardiovascular mortality in the general population. Multivariable-adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled using a random-effects model. Dose–response and subgroup analyses were also performed. Six cohort studies with seven datasets enrolling 13 960 participants were included. LPA was all measured by accelerometers. The HR of LPA per 30 min/day for cardiovascular mortality was pooled to be 0.80 (95% CI 0.67–0.96). This association was non-linearly shaped (Pnonlinearity < 0.01) and unaffected by sex difference. Moreover, substituting LPA for sedentary time of 30 min/day lowered the risk of cardiovascular mortality by 16% (95% CI 0.73–0.96). Results showed further that LPA was inferior to moderate-to-vigorous physical activity in reducing the risk of cardiovascular mortality when performed with an equal time-length set at 30 min/day (HR 0.83 vs. 0.54, Pcomparison = 0.046), but became comparable if at an equal activity-amount set at 150 metabolic equivalents-min/day (HR 0.67 vs. 0.54, Pcomparison = 0.41).
Conclusion
LPA shows potential in reducing the risk of cardiovascular mortality, and interventions targeting at LPA improvement are worth being encouraged.
Graphical Abstract
Graphical Abstract</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>32514573</pmid><doi>10.1093/ehjqcco/qcaa051</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2597-3856</orcidid></addata></record> |
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| ispartof | European heart journal. Quality of care & clinical outcomes, 2021-11, Vol.7 (5), p.496-504 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Cardiovascular disease Cardiovascular Diseases - prevention & control Disease management Exercise Exercise - physiology Female Health risks Humans Male Meta-analysis Mortality Proportional Hazards Models Prospective Studies Sedentary Behavior |
| title | Does objectively measured light-intensity physical activity reduce the risk of cardiovascular mortality? A meta-analysis |
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