Novel hepatitis B virus infection mouse model using herpes simplex virus type 1 thymidine kinase transgenic mice

Background and Aim The chronicity of hepatitis B virus (HBV) infection is the result of impaired HBV‐specific immune responses that cannot eliminate or cure the infected hepatocytes efficiently. Previous studies have used immunodeficient mice such as herpes simplex virus type 1 thymidine kinase NOD/...

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Veröffentlicht in:	Journal of gastroenterology and hepatology 2021-03, Vol.36 (3), p.782-789
Hauptverfasser:	Kanbe, Ayumu, Ishikawa, Tetsuya, Hara, Akira, Suemizu, Hiroshi, Nanizawa, Eri, Tamaki, Yuki, Ito, Hiroyasu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Alanine transaminase Animal models Chronic infection Ganciclovir GCV HBV Hepatitis B Hepatitis B surface antigen Hepatocytes Herpes simplex Herpes viruses HSV‐TK Immune response Immunodeficiency Immunological tolerance Infections Injection Interferon Liver Thymidine Thymidine kinase Transgenic mice Transplantation
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