Pullulan microneedle patches for the efficient transdermal administration of insulin envisioning diabetes treatment

[Display omitted] •Dissolvable pullulan microneedles were successfully prepared by solvent casting.•Pullulan-insulin microneedles successfully penetrate through the skin.•Storage at 4, 20 and 40 °C maintained the secondary structure of insulin.•Pullulan microneedles deliver 87% of insulin, 120 min a...

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Veröffentlicht in:	Carbohydrate polymers 2020-08, Vol.241, p.116314-116314, Article 116314
Hauptverfasser:	Fonseca, Daniela F.S., Costa, Paulo C., Almeida, Isabel F., Dias-Pereira, Patrícia, Correia-Sá, Inês, Bastos, Verónica, Oliveira, Helena, Duarte-Araújo, Margarida, Morato, Manuela, Vilela, Carla, Silvestre, Armando J.D., Freire, Carmen S.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Diabetes Mellitus - drug therapy Drug Delivery Systems - instrumentation Glucans - chemistry HaCaT Cells Humans Hypoglycemic Agents - administration & dosage Insulin Insulin - administration & dosage Microneedles Needles Polysaccharides Pullulan Transdermal drug delivery Transdermal Patch
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