Selective sensitivity of EZH2 inhibitors based on synthetic lethality in ARID1A-deficient gastric cancer

Background AT-rich interactive domain 1A ( ARID1A ) is a tumor suppressor gene that is frequently mutated in gastric cancer (GC). Although ARID1A mutations are not a druggable target for conventional treatments, novel therapeutic strategies based on a synthetic lethal approach are effective for ARID...

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Veröffentlicht in:	Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2021-01, Vol.24 (1), p.60-71
Hauptverfasser:	Yamada, Leo, Saito, Motonobu, Thar Min, Aung Kyi, Saito, Katsuharu, Ashizawa, Mai, Kase, Koji, Nakajima, Shotaro, Onozawa, Hisashi, Okayama, Hirokazu, Endo, Hisahito, Fujita, Shotaro, Sakamoto, Wataru, Saze, Zenichiro, Momma, Tomoyuki, Mimura, Kosaku, Ohki, Shinji, Kono, Koji
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Abdominal Surgery AKT protein Bioinformatics Cancer Research Cell proliferation Cell survival Cell viability Gastric cancer Gastroenterology Histone methyltransferase Homeostasis Kinases Lethality Medicine Medicine & Public Health Oncology Original Article Ovarian cancer Phosphorylation Signal transduction Surgical Oncology Tumor suppressor genes
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