Synthesis of novel 3,5,6-trisubstituted 2-pyridone derivatives and evaluation for their anti-inflammatory activity

[Display omitted] The inflammatory response is the reaction of living tissue to an injury of a foreign nature, such as infection and irritants, and occurs as part of the body's natural defence response. Compounds capable of inhibiting cyclooxygenase (COX) enzymes, especially COX-2, have great p...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2020-06, Vol.28 (12), p.115549-115549, Article 115549
Hauptverfasser:	Gonçalves, Davana S., de S. Melo, Samara M., Jacomini, Andrey P., J. V. da Silva, Michael, Pianoski, Karlos E., Ames, Franciele Q., Aguiar, Rafael P., Oliveira, Alisson Felipe, Volpato, Hélito, Bidóia, Danielle L., Nakamura, Celso V., Bersani-Amado, Ciomar A., Back, Davi F., Moura, Sidnei, Paula, Fávero R., Rosa, Fernanda A.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-pyridone Anti-inflammatory COXs
Online-Zugang:	Volltext
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