Quantification of global DNA methylation level using 5-methylcytosine dioxygenase

DNA methylation is one of the best studied epigenetic modifications. Alteration of the global DNA methylation level occurs in abnormal cells, such as those associated with cancers and Alzheimer’s disease. Several assays are used to determine the global DNA methylation level, including the bisulfite-...

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Veröffentlicht in:	Analytical and bioanalytical chemistry 2020-09, Vol.412 (22), p.5299-5305
Hauptverfasser:	Taka, Natsumi, Yoshida, Wataru
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine - metabolism Alzheimer's disease Analytical Chemistry Assaying Biochemistry Bisulfite Cells Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Chromatography, High Pressure Liquid CpG Islands Demethylation Deoxyribonucleic acid Dioxygenase Dioxygenases - metabolism DNA DNA damage DNA Methylation DNA-Binding Proteins - genetics Domains E coli Energy Transfer Enzyme-Linked Immunosorbent Assay Enzymes Epigenetic inheritance Escherichia coli Food Science Genomics HeLa Cells High performance liquid chromatography Humans Laboratory Medicine Liquid chromatography Mammalian cells Methylation Monitoring/Environmental Analysis Neurodegenerative diseases Oxidation Protein transport Proteins Proto-Oncogene Proteins - genetics Pyrimidines Research Paper Sulfites Translocation
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