Increased levels of BPI-ANCA in patients with primary Sjögren’s syndrome are associated with lung involvement
The goal of this study was to investigate the association between bactericidal permeability increasing (BPI)-antineutrophil cytoplasmic antibody (ANCA) protein levels and primary Sjogren's syndrome (pSS) with lung involvement, as well as the potential diagnostic performance of BPI-ANCA. The lev...
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| Veröffentlicht in: | Clinical biochemistry 2020-09, Vol.83, p.43-48 |
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| creator | Wu, Yanyao Yang, Yafei Qin, Yan Wang, Yanlin Feng, Min Zhao, Xiangcong Liang, Zhaojun Zhang, Chen Liu, Guangying Guo, Hui Luo, Jing |
| description | The goal of this study was to investigate the association between bactericidal permeability increasing (BPI)-antineutrophil cytoplasmic antibody (ANCA) protein levels and primary Sjogren's syndrome (pSS) with lung involvement, as well as the potential diagnostic performance of BPI-ANCA.
The levels of BPI-ANCA in pSS patients with (n = 36) and without (n = 85) lung involvement were measured using a commercial ELISA kit. Serological biomarkers and cytokines were measured in these patients as well. Lung involvement was determined by high-resolution computed tomography (HRCT) and/or clinical symptoms. The diagnostic performance of lung involvement was determined by receiver operating characteristic (ROC) curves.
The percentage of neutrophils (NEUT%), neutrophil–lymphocyte ratio (NLR), erythrocyte sedimentation rate (ESR), and the levels of BPI-ANCA, C-reactive protein (CRP), interleukin-2 (IL-2) and IL-6 exhibited an upward trend, while the percentage of lymphocytes (LYMP%) and albumin (ALB) level exhibited a downward trend in the lung involvement group. The combination of BPI-ANCA, NEUT% and ALB significantly increased the area under the ROC curve (AUC) to 0.837 (95% confidence interval: 0.742–0.907, sensitivity: 82.14%, specificity: 81.36%, P |
| doi_str_mv | 10.1016/j.clinbiochem.2020.05.018 |
| format | Article |
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The levels of BPI-ANCA in pSS patients with (n = 36) and without (n = 85) lung involvement were measured using a commercial ELISA kit. Serological biomarkers and cytokines were measured in these patients as well. Lung involvement was determined by high-resolution computed tomography (HRCT) and/or clinical symptoms. The diagnostic performance of lung involvement was determined by receiver operating characteristic (ROC) curves.
The percentage of neutrophils (NEUT%), neutrophil–lymphocyte ratio (NLR), erythrocyte sedimentation rate (ESR), and the levels of BPI-ANCA, C-reactive protein (CRP), interleukin-2 (IL-2) and IL-6 exhibited an upward trend, while the percentage of lymphocytes (LYMP%) and albumin (ALB) level exhibited a downward trend in the lung involvement group. The combination of BPI-ANCA, NEUT% and ALB significantly increased the area under the ROC curve (AUC) to 0.837 (95% confidence interval: 0.742–0.907, sensitivity: 82.14%, specificity: 81.36%, P < 0.001).
Increased BPI-ANCA was found in pSS patients with lung involvement and was associated with inflammation. A combination of BPI-ANCA, NEUT% and ALB had the best AUC, and may serve as anadjunct to distinguish between pSS patients with and without lung involvement.</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/j.clinbiochem.2020.05.018</identifier><identifier>PMID: 32502475</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Antibodies, Antineutrophil Cytoplasmic - blood ; Antibodies, Antineutrophil Cytoplasmic - immunology ; Antimicrobial Cationic Peptides - immunology ; Autoantibodies against bactericidal permeability increasing protein (BPI-ANCA) ; Biomarkers ; Blood Proteins - immunology ; Case-Control Studies ; Cytokines - blood ; Diagnosis, Differential ; Female ; Humans ; Lung Diseases - blood ; Lung Diseases - complications ; Lung Diseases - diagnosis ; Lung Diseases - immunology ; Lung involvement ; Male ; Middle Aged ; Primary Sjogren's syndrome ; ROC Curve ; Sensitivity and Specificity ; Sjogren's Syndrome - blood ; Sjogren's Syndrome - complications ; Sjogren's Syndrome - immunology</subject><ispartof>Clinical biochemistry, 2020-09, Vol.83, p.43-48</ispartof><rights>2020 The Canadian Society of Clinical Chemists</rights><rights>Copyright © 2020 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-17bd47c8f295b2a4c17d7c6b06d7dde41dc0c604a8b068173a406e4315864fed3</citedby><cites>FETCH-LOGICAL-c377t-17bd47c8f295b2a4c17d7c6b06d7dde41dc0c604a8b068173a406e4315864fed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009912020300758$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32502475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Yanyao</creatorcontrib><creatorcontrib>Yang, Yafei</creatorcontrib><creatorcontrib>Qin, Yan</creatorcontrib><creatorcontrib>Wang, Yanlin</creatorcontrib><creatorcontrib>Feng, Min</creatorcontrib><creatorcontrib>Zhao, Xiangcong</creatorcontrib><creatorcontrib>Liang, Zhaojun</creatorcontrib><creatorcontrib>Zhang, Chen</creatorcontrib><creatorcontrib>Liu, Guangying</creatorcontrib><creatorcontrib>Guo, Hui</creatorcontrib><creatorcontrib>Luo, Jing</creatorcontrib><title>Increased levels of BPI-ANCA in patients with primary Sjögren’s syndrome are associated with lung involvement</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>The goal of this study was to investigate the association between bactericidal permeability increasing (BPI)-antineutrophil cytoplasmic antibody (ANCA) protein levels and primary Sjogren's syndrome (pSS) with lung involvement, as well as the potential diagnostic performance of BPI-ANCA.
The levels of BPI-ANCA in pSS patients with (n = 36) and without (n = 85) lung involvement were measured using a commercial ELISA kit. Serological biomarkers and cytokines were measured in these patients as well. Lung involvement was determined by high-resolution computed tomography (HRCT) and/or clinical symptoms. The diagnostic performance of lung involvement was determined by receiver operating characteristic (ROC) curves.
The percentage of neutrophils (NEUT%), neutrophil–lymphocyte ratio (NLR), erythrocyte sedimentation rate (ESR), and the levels of BPI-ANCA, C-reactive protein (CRP), interleukin-2 (IL-2) and IL-6 exhibited an upward trend, while the percentage of lymphocytes (LYMP%) and albumin (ALB) level exhibited a downward trend in the lung involvement group. The combination of BPI-ANCA, NEUT% and ALB significantly increased the area under the ROC curve (AUC) to 0.837 (95% confidence interval: 0.742–0.907, sensitivity: 82.14%, specificity: 81.36%, P < 0.001).
Increased BPI-ANCA was found in pSS patients with lung involvement and was associated with inflammation. A combination of BPI-ANCA, NEUT% and ALB had the best AUC, and may serve as anadjunct to distinguish between pSS patients with and without lung involvement.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Antineutrophil Cytoplasmic - blood</subject><subject>Antibodies, Antineutrophil Cytoplasmic - immunology</subject><subject>Antimicrobial Cationic Peptides - immunology</subject><subject>Autoantibodies against bactericidal permeability increasing protein (BPI-ANCA)</subject><subject>Biomarkers</subject><subject>Blood Proteins - immunology</subject><subject>Case-Control Studies</subject><subject>Cytokines - blood</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Diseases - blood</subject><subject>Lung Diseases - complications</subject><subject>Lung Diseases - diagnosis</subject><subject>Lung Diseases - immunology</subject><subject>Lung involvement</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Primary Sjogren's syndrome</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>Sjogren's Syndrome - blood</subject><subject>Sjogren's Syndrome - complications</subject><subject>Sjogren's Syndrome - immunology</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1u1DAUxy1ERYfCFZDZsUl4thM7WQ6jUkaqaCVgbTn2S-tREg92ZlB3XIOL9ALchJPgMgNi2YVlP-v_ofcj5DWDkgGTbzelHfzU-WBvcSw5cCihLoE1T8iCNUoUvBXiKVkAQFu0jMMpeZ7SJo-8auQzcip4nZ-qXpDterIRTUJHB9zjkGjo6bvrdbH8uFpSP9GtmT1Oc6Lf_HxLt9GPJt7RT5uf9zcRp1_ffySa7iYXw4jUxHxSCtabOQf-cQy76Sbn7MOwxzEHvSAnvRkSvjzeZ-TL-_PPqw_F5dXFerW8LKxQai6Y6lylbNPztu64qSxTTlnZgXTKOayYs2AlVKbJXw1TwlQgsRKsbmTVoxNn5M0hdxvD1x2mWY8-WRwGM2HYJc0rBkKCkixL24PUxpBSxF4f19QM9ANwvdH_AdcPwDXUOgPP3lfHml03ovvn_Es4C1YHQWaLe49RJ5uBWnQ-op21C_4RNb8BIf-aRw</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Wu, Yanyao</creator><creator>Yang, Yafei</creator><creator>Qin, Yan</creator><creator>Wang, Yanlin</creator><creator>Feng, Min</creator><creator>Zhao, Xiangcong</creator><creator>Liang, Zhaojun</creator><creator>Zhang, Chen</creator><creator>Liu, Guangying</creator><creator>Guo, Hui</creator><creator>Luo, Jing</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202009</creationdate><title>Increased levels of BPI-ANCA in patients with primary Sjögren’s syndrome are associated with lung involvement</title><author>Wu, Yanyao ; Yang, Yafei ; Qin, Yan ; Wang, Yanlin ; Feng, Min ; Zhao, Xiangcong ; Liang, Zhaojun ; Zhang, Chen ; Liu, Guangying ; Guo, Hui ; Luo, Jing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-17bd47c8f295b2a4c17d7c6b06d7dde41dc0c604a8b068173a406e4315864fed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibodies, Antineutrophil Cytoplasmic - blood</topic><topic>Antibodies, Antineutrophil Cytoplasmic - immunology</topic><topic>Antimicrobial Cationic Peptides - immunology</topic><topic>Autoantibodies against bactericidal permeability increasing protein (BPI-ANCA)</topic><topic>Biomarkers</topic><topic>Blood Proteins - immunology</topic><topic>Case-Control Studies</topic><topic>Cytokines - blood</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Diseases - blood</topic><topic>Lung Diseases - complications</topic><topic>Lung Diseases - diagnosis</topic><topic>Lung Diseases - immunology</topic><topic>Lung involvement</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Primary Sjogren's syndrome</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><topic>Sjogren's Syndrome - blood</topic><topic>Sjogren's Syndrome - complications</topic><topic>Sjogren's Syndrome - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Yanyao</creatorcontrib><creatorcontrib>Yang, Yafei</creatorcontrib><creatorcontrib>Qin, Yan</creatorcontrib><creatorcontrib>Wang, Yanlin</creatorcontrib><creatorcontrib>Feng, Min</creatorcontrib><creatorcontrib>Zhao, Xiangcong</creatorcontrib><creatorcontrib>Liang, Zhaojun</creatorcontrib><creatorcontrib>Zhang, Chen</creatorcontrib><creatorcontrib>Liu, Guangying</creatorcontrib><creatorcontrib>Guo, Hui</creatorcontrib><creatorcontrib>Luo, Jing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Yanyao</au><au>Yang, Yafei</au><au>Qin, Yan</au><au>Wang, Yanlin</au><au>Feng, Min</au><au>Zhao, Xiangcong</au><au>Liang, Zhaojun</au><au>Zhang, Chen</au><au>Liu, Guangying</au><au>Guo, Hui</au><au>Luo, Jing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased levels of BPI-ANCA in patients with primary Sjögren’s syndrome are associated with lung involvement</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2020-09</date><risdate>2020</risdate><volume>83</volume><spage>43</spage><epage>48</epage><pages>43-48</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>The goal of this study was to investigate the association between bactericidal permeability increasing (BPI)-antineutrophil cytoplasmic antibody (ANCA) protein levels and primary Sjogren's syndrome (pSS) with lung involvement, as well as the potential diagnostic performance of BPI-ANCA.
The levels of BPI-ANCA in pSS patients with (n = 36) and without (n = 85) lung involvement were measured using a commercial ELISA kit. Serological biomarkers and cytokines were measured in these patients as well. Lung involvement was determined by high-resolution computed tomography (HRCT) and/or clinical symptoms. The diagnostic performance of lung involvement was determined by receiver operating characteristic (ROC) curves.
The percentage of neutrophils (NEUT%), neutrophil–lymphocyte ratio (NLR), erythrocyte sedimentation rate (ESR), and the levels of BPI-ANCA, C-reactive protein (CRP), interleukin-2 (IL-2) and IL-6 exhibited an upward trend, while the percentage of lymphocytes (LYMP%) and albumin (ALB) level exhibited a downward trend in the lung involvement group. The combination of BPI-ANCA, NEUT% and ALB significantly increased the area under the ROC curve (AUC) to 0.837 (95% confidence interval: 0.742–0.907, sensitivity: 82.14%, specificity: 81.36%, P < 0.001).
Increased BPI-ANCA was found in pSS patients with lung involvement and was associated with inflammation. A combination of BPI-ANCA, NEUT% and ALB had the best AUC, and may serve as anadjunct to distinguish between pSS patients with and without lung involvement.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32502475</pmid><doi>10.1016/j.clinbiochem.2020.05.018</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Antibodies, Antineutrophil Cytoplasmic - blood Antibodies, Antineutrophil Cytoplasmic - immunology Antimicrobial Cationic Peptides - immunology Autoantibodies against bactericidal permeability increasing protein (BPI-ANCA) Biomarkers Blood Proteins - immunology Case-Control Studies Cytokines - blood Diagnosis, Differential Female Humans Lung Diseases - blood Lung Diseases - complications Lung Diseases - diagnosis Lung Diseases - immunology Lung involvement Male Middle Aged Primary Sjogren's syndrome ROC Curve Sensitivity and Specificity Sjogren's Syndrome - blood Sjogren's Syndrome - complications Sjogren's Syndrome - immunology |
| title | Increased levels of BPI-ANCA in patients with primary Sjögren’s syndrome are associated with lung involvement |
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