(−)‐o‐[11C]methyl‐trans‐decalinvesamicol ((−)‐[11C]OMDV) as a PET ligand for the vesicular acetylcholine transporter

To develop a PET imaging agent to visualize brain cholinergic neurons and synaptic changes caused by Alzheimer's disease, (−)‐ and (+)‐o‐[11C]methyl‐trans‐decalinvesamicol ([11C]OMDV) were isolated and investigated for differences in not only their binding affinity and selectivity to vesicular...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Synapse (New York, N.Y.) N.Y.), 2020-11, Vol.74 (11), p.e22176-n/a
Hauptverfasser:	Miwa, Daisuke, Kitamura, Yoji, Kozaka, Takashi, Shigeno, Taiki, Ogawa, Kazuma, Taki, Junichi, Kinuya, Seigo, Shiba, Kazuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Affinity Alzheimer's disease Blood-brain barrier Computed tomography Enantiomers High-performance liquid chromatography imaging probe Isomers Ligands Membrane permeability Neurodegenerative diseases Neuroimaging Pentazocine PET Positron emission tomography VAChT Vesamicol vesamicol analog Vesicular acetylcholine transporter
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!