A positively selected FBN1 missense variant reduces height in Peruvian individuals

On average, Peruvian individuals are among the shortest in the world 1 . Here we show that Native American ancestry is associated with reduced height in an ethnically diverse group of Peruvian individuals, and identify a population-specific, missense variant in the FBN1 gene (E1297G) that is signifi...

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Veröffentlicht in:	Nature (London) 2020-06, Vol.582 (7811), p.234-239
Hauptverfasser:	Asgari, Samira, Luo, Yang, Akbari, Ali, Belbin, Gillian M., Li, Xinyi, Harris, Daniel N., Selig, Martin, Bartell, Eric, Calderon, Roger, Slowikowski, Kamil, Contreras, Carmen, Yataco, Rosa, Galea, Jerome T., Jimenez, Judith, Coit, Julia M., Farroñay, Chandel, Nazarian, Rosalynn M., O’Connor, Timothy D., Dietz, Harry C., Hirschhorn, Joel N., Guio, Heinner, Lecca, Leonid, Kenny, Eimear E., Freeman, Esther E., Murray, Megan B., Raychaudhuri, Soumya
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/51 14/1 14/19 14/28 45 45/22 45/43 631/181/457/649 631/208/182 631/208/205/2138 Body Height - genetics Coastal environments Confidence intervals Extracellular matrix Female Fibrillin Fibrillin-1 - genetics Gene Frequency Genome-Wide Association Study Haplotypes Heredity Humanities and Social Sciences Humans Hypotheses Indians, South American - genetics Male Matrix protein Microfibrils Microfibrils - chemistry Microfibrils - genetics Minority & ethnic groups multidisciplinary Mutation, Missense Observations Peru Population Populations Positive selection Science Science (multidisciplinary) Selection, Genetic Stature
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