uPA alleviates kaolin-induced hydrocephalus by promoting the release and activation of hepatocyte growth factor in rats

•uPA significantly increased the concentration of HGF in the CSF of kaolin-induced hydrocephalic rats.•uPA promoted the activation of HGF in kaolin-induced hydrocephalic rats.•HGF plays a pivotal role in uPA-triggered inhibiting of subarachnoid fibrosis and alleviating of hydrocephalus. Urokinase-ty...

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Veröffentlicht in:	Neuroscience letters 2020-07, Vol.731, p.135011-135011, Article 135011
Hauptverfasser:	Feng, Zhou, Liu, Shengyan, Chen, Qianwei, Tan, Qiang, Xian, Jishu, Feng, Hua, Chen, Zhi, Li, Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - drug effects Brain - metabolism Disease Models, Animal Hepatocyte growth factor Hepatocyte Growth Factor - metabolism Hydrocephalus Hydrocephalus - drug therapy Hydrocephalus - metabolism Hydrocephalus - pathology Kaolin - pharmacology Male Rats, Sprague-Dawley Subarachnoid fibrosis Transforming Growth Factor beta1 - cerebrospinal fluid Transforming growth factor- β1 Urokinase-type plasminogen activator Urokinase-Type Plasminogen Activator - metabolism Urokinase-Type Plasminogen Activator - pharmacology
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