Crocin Reverses Depression-Like Behavior in Parkinson Disease Mice via VTA-mPFC Pathway

Depression is a common non-motor symptom in patients with Parkinson’s disease (PD) and difficult to treat. Crocin is a natural multipotential neuroprotective compound that has been shown to elicit antidepressant activity and is promising for the therapy of neuropsychological diseases. Here, we inves...

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Veröffentlicht in:	Molecular neurobiology 2020-07, Vol.57 (7), p.3158-3170
Hauptverfasser:	Tang, Juanjuan, Lu, Linyu, Wang, Qisheng, Liu, Hou, Xue, Wenda, Zhou, Tong, Xu, Liantiao, Wang, Kai, Wu, Die, Wei, Fei, Tao, Weiwei, Chen, Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antidepressants Behavior, Animal - drug effects Biomedical and Life Sciences Biomedicine Carotenoids - pharmacology Cell Biology Depression - metabolism Dopamine receptors Glutamate receptors Male Mental depression Mice Movement disorders MPTP Neural Pathways - drug effects Neurobiology Neurodegenerative diseases Neurology Neuronal Plasticity - drug effects Neurons Neuroplasticity Neuroprotection Neurosciences Original Article Parkinson's disease Parkinsonian Disorders - metabolism Postsynaptic density proteins Prefrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Rapamycin Receptors, AMPA - metabolism Signal Transduction - drug effects Swimming behavior Synapsin Synapsins - metabolism Synaptic plasticity TOR protein Ventral Tegmental Area - drug effects Ventral Tegmental Area - metabolism Ventral tegmentum
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