Intrauterine RAS programming alteration-mediated susceptibility and heritability of temporal lobe epilepsy in male offspring rats induced by prenatal dexamethasone exposure

Partial temporal lobe epilepsy (TLE) has an intrauterine developmental origin. This study was aimed at elucidating the heritable effects and programming mechanism of TLE in offspring rats induced by prenatal dexamethasone exposure (PDE). Pregnant Wistar rats were injected subcutaneously with dexamet...

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Veröffentlicht in:	Archives of toxicology 2020-09, Vol.94 (9), p.3201-3215
Hauptverfasser:	Hu, Shuwei, Yi, Yiwen, Jiang, Tao, Jiao, Zhexiao, Dai, Shiyun, Gong, Xiaohan, Li, Ke, Wang, Hui, Xu, Dan
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Biomedical and Life Sciences Biomedicine CCAAT/enhancer-binding protein Classical pathway Dexamethasone EEG Electroencephalography Environmental Health Epilepsy Event-related potentials Exposure Fetuses Glucocorticoids Glutamate dehydrogenase Heritability Hippocampus HMGB1 protein Lithium Occupational Medicine/Industrial Medicine Offspring Organ Toxicity and Mechanisms Peptidyl-dipeptidase A Pharmacology/Toxicology Pilocarpine Prenatal experience Programming Receptors Renin Rodents Steroids Temporal lobe TLR4 protein Toll-like receptors
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