Association between human gray matter metabotropic glutamate receptor-5 availability in vivo and white matter properties: a [11C]ABP688 PET and diffusion tensor imaging study

Excitatory corticofugal projections in the subcortical white matter (WM) convey signals arising from local neuronal activity in the gray matter (GM). We hypothesized that metabotropic glutamate receptor-5 (mGluR5) availability in GM, as a surrogate marker for local glutamatergic neuronal activity, c...

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Veröffentlicht in:	Brain Structure and Function 2020-07, Vol.225 (6), p.1805-1816
Hauptverfasser:	Kim, Song E., Joo, Yo-Han, Son, Young-Don, Kim, Hang-Keun, Lee, Sang-Yoon, Lee, Min-Woo, Ido, Tatsuo, Kim, Jong-Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anisotropy Biomedical and Life Sciences Biomedicine Brain - metabolism Brain Mapping - methods Carbon Radioisotopes Cell Biology Corpus callosum Diffusion Tensor Imaging Female Glutamatergic transmission Glutamic acid receptors Glutamic acid receptors (metabotropic) Gray Matter - metabolism Humans Image processing Magnetic resonance imaging Male Mental disorders Neuroimaging Neurology Neurosciences Original Article Positron emission tomography Receptor, Metabotropic Glutamate 5 - metabolism Statistical analysis Substantia alba Substantia grisea White Matter - metabolism
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