Suppressed microRNA‐195‐5p expression in mycosis fungoides promotes tumor cell proliferation

Background Several cancers, including mycosis fungoides (MF), have reported dysregulation of miR‐195‐5p. miR‐195‐5p plays a role in cell cycle regulation in several malignant diseases. Objectives This study aimed to investigate: (a) the expression level of miR‐195‐5p in lesional MF skin biopsies and...

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Veröffentlicht in:	Experimental dermatology 2021-08, Vol.30 (8), p.1141-1149
Hauptverfasser:	Rittig, Anne H., Johansen, Claus, Celis, Pamela, Odum, Niels, Litman, Thomas, Woetmann, Anders, Lindahl, Lise M., Iversen, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - genetics ARL2 Biopsy cancer Cell cycle cell cycle arrest Cell Cycle Checkpoints - genetics Cell Line, Tumor Cell proliferation Cell Proliferation - genetics Chromosome 5 cutaneous T‐cell lymphoma Disease Disease Progression DNA microarrays Down-Regulation Flow cytometry Fungal infections Gene Expression Regulation, Neoplastic GTP-Binding Proteins - genetics Humans microarray microRNA MicroRNAs - metabolism miRNA Mycosis Mycosis fungoides Mycosis Fungoides - genetics Mycosis Fungoides - pathology Polymerase chain reaction proliferation Ribosylation siRNA Skin diseases Skin Neoplasms - genetics Skin Neoplasms - pathology Transfection tumor suppressor Tumor suppressor genes Western blotting
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