Can ocular changes be detected early in children and adolescents with type 1 diabetes mellitus without retinopathy by using optical biometry and optical coherence tomography?
Purpose To determine early ocular changes in children and adolescents with type 1 diabetes mellitus without retinopathy (T1DM-woR) by optical biometry (OB) and optical coherence tomography (OCT). Methods Seventy children and adolescents with T1DM-woR (patient group) and 72 healthy children and adole...
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| Veröffentlicht in: | International ophthalmology 2020-10, Vol.40 (10), p.2503-2514 |
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| creator | Öztürk, Hakan Özen, Bediz Manyas, Hayrullah Çatlı, Gönül Dündar, Bumin |
| description | Purpose
To determine early ocular changes in children and adolescents with type 1 diabetes mellitus without retinopathy (T1DM-woR) by optical biometry (OB) and optical coherence tomography (OCT).
Methods
Seventy children and adolescents with T1DM-woR (patient group) and 72 healthy children and adolescents (control group) were included. Demographic data, anthropometric measurements and anterior–posterior segment parameters of groups were compared. Correlations between ocular parameters and glycosylated hemoglobin (HbA1c) level, age at diabetes mellitus (DM) onset and DM duration were evaluated.
Results
Patients with T1DM-woR had significantly shallower anterior chambers (3.50 ± 0.12 vs 3.67 ± 0.11 mm,
p
|
| doi_str_mv | 10.1007/s10792-020-01430-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2409195332</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2409195332</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-8d36f8d4590db0c7e7488d48a66cf8ccec319e4d2283848fa1d020151168459e3</originalsourceid><addsrcrecordid>eNp9UbuO1TAQtRCIvSz8AAVySRPwK4lTIXS1PKSVaKC2HHty45VjB9sRyk_xjZjNLiXVSHMeozMHodeUvKOE9O8zJf3AGsJIQ6jgpBFP0Im2PW9Yx8lTdCK0a5u2J_QKvcj5jhAy9EP3HF1xJqRs5XBCv8864Gg2rxM2sw4XyHgEbKGAKWAx6OR37EIFnbcJAtbBYm2jh2wglIx_uTLjsq-AKbZOj1WZ8QLeu7IdaNwKTlBciKsu847HHW_ZhQuOa3FGezy6uEBJ-73349LEGeo9A7jEJV6SXuf9w0v0bNI-w6uHeY1-fLr5fv7S3H77_PX88bYxXPSlkZZ3k7SiHYgdiemhr3mtkLrrzCSNAcPpAMIyJrkUctLU1i_SltJOVhHwa_T28F1T_LlBLmpxNa_3OkDcsmKCDHRoOWeVyg6qSTHnBJNak1t02hUl6m9P6uhJ1QvqviclqujNg_82LmD_SR6LqQR-EHKFaitJ3cUthZr5f7Z_AGg1oa4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2409195332</pqid></control><display><type>article</type><title>Can ocular changes be detected early in children and adolescents with type 1 diabetes mellitus without retinopathy by using optical biometry and optical coherence tomography?</title><source>SpringerLink Journals - AutoHoldings</source><creator>Öztürk, Hakan ; Özen, Bediz ; Manyas, Hayrullah ; Çatlı, Gönül ; Dündar, Bumin</creator><creatorcontrib>Öztürk, Hakan ; Özen, Bediz ; Manyas, Hayrullah ; Çatlı, Gönül ; Dündar, Bumin</creatorcontrib><description>Purpose
To determine early ocular changes in children and adolescents with type 1 diabetes mellitus without retinopathy (T1DM-woR) by optical biometry (OB) and optical coherence tomography (OCT).
Methods
Seventy children and adolescents with T1DM-woR (patient group) and 72 healthy children and adolescents (control group) were included. Demographic data, anthropometric measurements and anterior–posterior segment parameters of groups were compared. Correlations between ocular parameters and glycosylated hemoglobin (HbA1c) level, age at diabetes mellitus (DM) onset and DM duration were evaluated.
Results
Patients with T1DM-woR had significantly shallower anterior chambers (3.50 ± 0.12 vs 3.67 ± 0.11 mm,
p
< 0.001), thicker lenses (3.65 ± 0.15 vs 3.37 ± 0.14 mm,
p
< 0.001), thinner central retinal nerve fiber layer (RNFL) thicknesses (95.3 ± 6.7 vs 104.8 ± 6.2 µm,
p
< 0.001) and thinner central choroidal thicknesses (292.8 ± 23.6 vs 325.1 ± 24.7 µm,
p
< 0.001) than healthy individuals. As the lens thickness (LT) increased, anterior chamber depth (ACD) decreased in patient group (
r
= − 0.368,
p
= 0.040). Other anterior (central corneal thickness, axial length, keratometry, spherical equivalent) and posterior (superior temporal, superior nasal, nasal, inferior nasal, inferior temporal, temporal RNFL thicknesses; nasal and temporal choroidal thicknesses; central part’s and inner–outer macular segments’ thickness and volume measurements) segment parameters of groups were similar (
p
> 0.05). In patient group, as HbA1c level increased, central RNFL and choroidal thicknesses decreased (
r
= − 0.639,
p
< 0.001;
r
= − 0.486,
p
= 0.010, respectively).
Conclusions
In patients with T1DM, we found that LT increased, and ACD, central RNFL and choroidal thicknesses decreased by OB and OCT before visible findings appeared in routine ophthalmological examination. Determination of early changes is warning to physician and patient in order to prevent more serious damages occurring later.</description><identifier>ISSN: 0165-5701</identifier><identifier>EISSN: 1573-2630</identifier><identifier>DOI: 10.1007/s10792-020-01430-4</identifier><identifier>PMID: 32488589</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Medicine ; Medicine & Public Health ; Ophthalmology ; Original Paper</subject><ispartof>International ophthalmology, 2020-10, Vol.40 (10), p.2503-2514</ispartof><rights>Springer Nature B.V. 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-8d36f8d4590db0c7e7488d48a66cf8ccec319e4d2283848fa1d020151168459e3</citedby><cites>FETCH-LOGICAL-c347t-8d36f8d4590db0c7e7488d48a66cf8ccec319e4d2283848fa1d020151168459e3</cites><orcidid>0000-0002-7506-061X ; 0000-0002-4307-3360 ; 0000-0002-4775-2950 ; 0000-0002-0488-6377 ; 0000-0001-9020-3810</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10792-020-01430-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10792-020-01430-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32488589$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Öztürk, Hakan</creatorcontrib><creatorcontrib>Özen, Bediz</creatorcontrib><creatorcontrib>Manyas, Hayrullah</creatorcontrib><creatorcontrib>Çatlı, Gönül</creatorcontrib><creatorcontrib>Dündar, Bumin</creatorcontrib><title>Can ocular changes be detected early in children and adolescents with type 1 diabetes mellitus without retinopathy by using optical biometry and optical coherence tomography?</title><title>International ophthalmology</title><addtitle>Int Ophthalmol</addtitle><addtitle>Int Ophthalmol</addtitle><description>Purpose
To determine early ocular changes in children and adolescents with type 1 diabetes mellitus without retinopathy (T1DM-woR) by optical biometry (OB) and optical coherence tomography (OCT).
Methods
Seventy children and adolescents with T1DM-woR (patient group) and 72 healthy children and adolescents (control group) were included. Demographic data, anthropometric measurements and anterior–posterior segment parameters of groups were compared. Correlations between ocular parameters and glycosylated hemoglobin (HbA1c) level, age at diabetes mellitus (DM) onset and DM duration were evaluated.
Results
Patients with T1DM-woR had significantly shallower anterior chambers (3.50 ± 0.12 vs 3.67 ± 0.11 mm,
p
< 0.001), thicker lenses (3.65 ± 0.15 vs 3.37 ± 0.14 mm,
p
< 0.001), thinner central retinal nerve fiber layer (RNFL) thicknesses (95.3 ± 6.7 vs 104.8 ± 6.2 µm,
p
< 0.001) and thinner central choroidal thicknesses (292.8 ± 23.6 vs 325.1 ± 24.7 µm,
p
< 0.001) than healthy individuals. As the lens thickness (LT) increased, anterior chamber depth (ACD) decreased in patient group (
r
= − 0.368,
p
= 0.040). Other anterior (central corneal thickness, axial length, keratometry, spherical equivalent) and posterior (superior temporal, superior nasal, nasal, inferior nasal, inferior temporal, temporal RNFL thicknesses; nasal and temporal choroidal thicknesses; central part’s and inner–outer macular segments’ thickness and volume measurements) segment parameters of groups were similar (
p
> 0.05). In patient group, as HbA1c level increased, central RNFL and choroidal thicknesses decreased (
r
= − 0.639,
p
< 0.001;
r
= − 0.486,
p
= 0.010, respectively).
Conclusions
In patients with T1DM, we found that LT increased, and ACD, central RNFL and choroidal thicknesses decreased by OB and OCT before visible findings appeared in routine ophthalmological examination. Determination of early changes is warning to physician and patient in order to prevent more serious damages occurring later.</description><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Original Paper</subject><issn>0165-5701</issn><issn>1573-2630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9UbuO1TAQtRCIvSz8AAVySRPwK4lTIXS1PKSVaKC2HHty45VjB9sRyk_xjZjNLiXVSHMeozMHodeUvKOE9O8zJf3AGsJIQ6jgpBFP0Im2PW9Yx8lTdCK0a5u2J_QKvcj5jhAy9EP3HF1xJqRs5XBCv8864Gg2rxM2sw4XyHgEbKGAKWAx6OR37EIFnbcJAtbBYm2jh2wglIx_uTLjsq-AKbZOj1WZ8QLeu7IdaNwKTlBciKsu847HHW_ZhQuOa3FGezy6uEBJ-73349LEGeo9A7jEJV6SXuf9w0v0bNI-w6uHeY1-fLr5fv7S3H77_PX88bYxXPSlkZZ3k7SiHYgdiemhr3mtkLrrzCSNAcPpAMIyJrkUctLU1i_SltJOVhHwa_T28F1T_LlBLmpxNa_3OkDcsmKCDHRoOWeVyg6qSTHnBJNak1t02hUl6m9P6uhJ1QvqviclqujNg_82LmD_SR6LqQR-EHKFaitJ3cUthZr5f7Z_AGg1oa4</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Öztürk, Hakan</creator><creator>Özen, Bediz</creator><creator>Manyas, Hayrullah</creator><creator>Çatlı, Gönül</creator><creator>Dündar, Bumin</creator><general>Springer Netherlands</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7506-061X</orcidid><orcidid>https://orcid.org/0000-0002-4307-3360</orcidid><orcidid>https://orcid.org/0000-0002-4775-2950</orcidid><orcidid>https://orcid.org/0000-0002-0488-6377</orcidid><orcidid>https://orcid.org/0000-0001-9020-3810</orcidid></search><sort><creationdate>20201001</creationdate><title>Can ocular changes be detected early in children and adolescents with type 1 diabetes mellitus without retinopathy by using optical biometry and optical coherence tomography?</title><author>Öztürk, Hakan ; Özen, Bediz ; Manyas, Hayrullah ; Çatlı, Gönül ; Dündar, Bumin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-8d36f8d4590db0c7e7488d48a66cf8ccec319e4d2283848fa1d020151168459e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Original Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Öztürk, Hakan</creatorcontrib><creatorcontrib>Özen, Bediz</creatorcontrib><creatorcontrib>Manyas, Hayrullah</creatorcontrib><creatorcontrib>Çatlı, Gönül</creatorcontrib><creatorcontrib>Dündar, Bumin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Öztürk, Hakan</au><au>Özen, Bediz</au><au>Manyas, Hayrullah</au><au>Çatlı, Gönül</au><au>Dündar, Bumin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Can ocular changes be detected early in children and adolescents with type 1 diabetes mellitus without retinopathy by using optical biometry and optical coherence tomography?</atitle><jtitle>International ophthalmology</jtitle><stitle>Int Ophthalmol</stitle><addtitle>Int Ophthalmol</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>40</volume><issue>10</issue><spage>2503</spage><epage>2514</epage><pages>2503-2514</pages><issn>0165-5701</issn><eissn>1573-2630</eissn><abstract>Purpose
To determine early ocular changes in children and adolescents with type 1 diabetes mellitus without retinopathy (T1DM-woR) by optical biometry (OB) and optical coherence tomography (OCT).
Methods
Seventy children and adolescents with T1DM-woR (patient group) and 72 healthy children and adolescents (control group) were included. Demographic data, anthropometric measurements and anterior–posterior segment parameters of groups were compared. Correlations between ocular parameters and glycosylated hemoglobin (HbA1c) level, age at diabetes mellitus (DM) onset and DM duration were evaluated.
Results
Patients with T1DM-woR had significantly shallower anterior chambers (3.50 ± 0.12 vs 3.67 ± 0.11 mm,
p
< 0.001), thicker lenses (3.65 ± 0.15 vs 3.37 ± 0.14 mm,
p
< 0.001), thinner central retinal nerve fiber layer (RNFL) thicknesses (95.3 ± 6.7 vs 104.8 ± 6.2 µm,
p
< 0.001) and thinner central choroidal thicknesses (292.8 ± 23.6 vs 325.1 ± 24.7 µm,
p
< 0.001) than healthy individuals. As the lens thickness (LT) increased, anterior chamber depth (ACD) decreased in patient group (
r
= − 0.368,
p
= 0.040). Other anterior (central corneal thickness, axial length, keratometry, spherical equivalent) and posterior (superior temporal, superior nasal, nasal, inferior nasal, inferior temporal, temporal RNFL thicknesses; nasal and temporal choroidal thicknesses; central part’s and inner–outer macular segments’ thickness and volume measurements) segment parameters of groups were similar (
p
> 0.05). In patient group, as HbA1c level increased, central RNFL and choroidal thicknesses decreased (
r
= − 0.639,
p
< 0.001;
r
= − 0.486,
p
= 0.010, respectively).
Conclusions
In patients with T1DM, we found that LT increased, and ACD, central RNFL and choroidal thicknesses decreased by OB and OCT before visible findings appeared in routine ophthalmological examination. Determination of early changes is warning to physician and patient in order to prevent more serious damages occurring later.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>32488589</pmid><doi>10.1007/s10792-020-01430-4</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-7506-061X</orcidid><orcidid>https://orcid.org/0000-0002-4307-3360</orcidid><orcidid>https://orcid.org/0000-0002-4775-2950</orcidid><orcidid>https://orcid.org/0000-0002-0488-6377</orcidid><orcidid>https://orcid.org/0000-0001-9020-3810</orcidid></addata></record> |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Medicine Medicine & Public Health Ophthalmology Original Paper |
| title | Can ocular changes be detected early in children and adolescents with type 1 diabetes mellitus without retinopathy by using optical biometry and optical coherence tomography? |
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