CD25+FOXP3+ and CD4+CD25+ cells distribution in decidual departments of women with severe and mild pre‐eclampsia: Comparison with healthy pregnancies
Problem The aim of this study was to quantify and compare the distribution of regulatory CD25+FOXP3+ and activated CD4+CD25+ T cells in decidua basalis and parietalis of severe and mild pre‐eclampsia (PE) to normal healthy pregnancies. Method of study Decidual tissue (decidua basalis and parietalis)...
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| Veröffentlicht in: | American journal of reproductive immunology (1989) 2020-09, Vol.84 (3), p.e13281-n/a |
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| container_title | American journal of reproductive immunology (1989) |
| container_volume | 84 |
| creator | Orlovic Vlaho, Martina Tomic, Vajdana Vukojevic, Katarina Vasilj, Anja Pejic, Renato Lesko, Josip Soljic, Violeta |
| description | Problem
The aim of this study was to quantify and compare the distribution of regulatory CD25+FOXP3+ and activated CD4+CD25+ T cells in decidua basalis and parietalis of severe and mild pre‐eclampsia (PE) to normal healthy pregnancies.
Method of study
Decidual tissue (decidua basalis and parietalis) of 13 women with mild PE, 15 women with severe PE, and 19 women with healthy term pregnancies were analyzed by immunohistochemistry and double immunofluorescence.
Results
The total number of CD25+FOXP3+ cells/mm2 in decidua basalis was decreased in the severe and mild PE versus normal pregnancy group. The total number of CD4+CD25+ cells/mm2 in decidua basalis was decreased in the severe PE versus normal pregnancy group. The number of CD25+FOXP3+ and CD4+CD25+ cells in decidua parietalis was decreased in both PE groups.
Conclusion
Our data suggest that immunological changes of PE reflect on decidua basalis and parietalis and emphasize the importance of characterizing T cells in both decidual departments. |
| doi_str_mv | 10.1111/aji.13281 |
| format | Article |
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The aim of this study was to quantify and compare the distribution of regulatory CD25+FOXP3+ and activated CD4+CD25+ T cells in decidua basalis and parietalis of severe and mild pre‐eclampsia (PE) to normal healthy pregnancies.
Method of study
Decidual tissue (decidua basalis and parietalis) of 13 women with mild PE, 15 women with severe PE, and 19 women with healthy term pregnancies were analyzed by immunohistochemistry and double immunofluorescence.
Results
The total number of CD25+FOXP3+ cells/mm2 in decidua basalis was decreased in the severe and mild PE versus normal pregnancy group. The total number of CD4+CD25+ cells/mm2 in decidua basalis was decreased in the severe PE versus normal pregnancy group. The number of CD25+FOXP3+ and CD4+CD25+ cells in decidua parietalis was decreased in both PE groups.
Conclusion
Our data suggest that immunological changes of PE reflect on decidua basalis and parietalis and emphasize the importance of characterizing T cells in both decidual departments.</description><identifier>ISSN: 1046-7408</identifier><identifier>EISSN: 1600-0897</identifier><identifier>DOI: 10.1111/aji.13281</identifier><language>eng</language><publisher>New Haven: Wiley Subscription Services, Inc</publisher><subject>CD25 antigen ; CD4 antigen ; Decidua ; Eclampsia ; forkhead transcription factors ; Foxp3 protein ; Immunofluorescence ; Immunohistochemistry ; Lymphocytes T ; Preeclampsia ; Pregnancy ; pre‐eclampsia ; regulatory ; T‐lymphocytes</subject><ispartof>American journal of reproductive immunology (1989), 2020-09, Vol.84 (3), p.e13281-n/a</ispartof><rights>2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>Copyright © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2601-500ee88c07f6eeef792ab7460608ca6724970da351c11880039af10d69a1655f3</citedby><cites>FETCH-LOGICAL-c2601-500ee88c07f6eeef792ab7460608ca6724970da351c11880039af10d69a1655f3</cites><orcidid>0000-0002-5337-0780</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faji.13281$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faji.13281$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Orlovic Vlaho, Martina</creatorcontrib><creatorcontrib>Tomic, Vajdana</creatorcontrib><creatorcontrib>Vukojevic, Katarina</creatorcontrib><creatorcontrib>Vasilj, Anja</creatorcontrib><creatorcontrib>Pejic, Renato</creatorcontrib><creatorcontrib>Lesko, Josip</creatorcontrib><creatorcontrib>Soljic, Violeta</creatorcontrib><title>CD25+FOXP3+ and CD4+CD25+ cells distribution in decidual departments of women with severe and mild pre‐eclampsia: Comparison with healthy pregnancies</title><title>American journal of reproductive immunology (1989)</title><description>Problem
The aim of this study was to quantify and compare the distribution of regulatory CD25+FOXP3+ and activated CD4+CD25+ T cells in decidua basalis and parietalis of severe and mild pre‐eclampsia (PE) to normal healthy pregnancies.
Method of study
Decidual tissue (decidua basalis and parietalis) of 13 women with mild PE, 15 women with severe PE, and 19 women with healthy term pregnancies were analyzed by immunohistochemistry and double immunofluorescence.
Results
The total number of CD25+FOXP3+ cells/mm2 in decidua basalis was decreased in the severe and mild PE versus normal pregnancy group. The total number of CD4+CD25+ cells/mm2 in decidua basalis was decreased in the severe PE versus normal pregnancy group. The number of CD25+FOXP3+ and CD4+CD25+ cells in decidua parietalis was decreased in both PE groups.
Conclusion
Our data suggest that immunological changes of PE reflect on decidua basalis and parietalis and emphasize the importance of characterizing T cells in both decidual departments.</description><subject>CD25 antigen</subject><subject>CD4 antigen</subject><subject>Decidua</subject><subject>Eclampsia</subject><subject>forkhead transcription factors</subject><subject>Foxp3 protein</subject><subject>Immunofluorescence</subject><subject>Immunohistochemistry</subject><subject>Lymphocytes T</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>pre‐eclampsia</subject><subject>regulatory</subject><subject>T‐lymphocytes</subject><issn>1046-7408</issn><issn>1600-0897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kc9KxDAQxoso-PfgGwS8KEvdSdqmqTep_xHWg4K3EtOpm6VtatK67M1H8Ob7-SRmdz0JzmU-ht83zPAFwSGFU-prLGf6lEZM0I1gh3KAEESWbnoNMQ_TGMR2sOvcDMDPo3Qn-MovWDK6mjw_RCMi25LkF_FoNSMK69qRUrve6peh16YluiUlKl0Osvaik7ZvsO0dMRWZGy_JXPdT4vAdLa62NbouSWfx--MTVS2bzml5RnLTeK925tcwRVn308USfG1lqzS6_WCrkrXDg9--FzxdXT7mN-H95Po2P78PFeNAwwQAUQgFacURsUozJl_SmAMHoSRPWZylUMoooYpSIQCiTFYUSp5JypOkivaC4_Xezpq3AV1fNNotP5ctmsEVLIaMZgmLwKNHf9CZGWzrr_NUxJKECRCeOllTyhrnLFZFZ3Uj7aKgUCwjKnxExSoiz47X7FzXuPgfLM7vbteOHyrmkfU</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Orlovic Vlaho, Martina</creator><creator>Tomic, Vajdana</creator><creator>Vukojevic, Katarina</creator><creator>Vasilj, Anja</creator><creator>Pejic, Renato</creator><creator>Lesko, Josip</creator><creator>Soljic, Violeta</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5337-0780</orcidid></search><sort><creationdate>202009</creationdate><title>CD25+FOXP3+ and CD4+CD25+ cells distribution in decidual departments of women with severe and mild pre‐eclampsia: Comparison with healthy pregnancies</title><author>Orlovic Vlaho, Martina ; Tomic, Vajdana ; Vukojevic, Katarina ; Vasilj, Anja ; Pejic, Renato ; Lesko, Josip ; Soljic, Violeta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2601-500ee88c07f6eeef792ab7460608ca6724970da351c11880039af10d69a1655f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>CD25 antigen</topic><topic>CD4 antigen</topic><topic>Decidua</topic><topic>Eclampsia</topic><topic>forkhead transcription factors</topic><topic>Foxp3 protein</topic><topic>Immunofluorescence</topic><topic>Immunohistochemistry</topic><topic>Lymphocytes T</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>pre‐eclampsia</topic><topic>regulatory</topic><topic>T‐lymphocytes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Orlovic Vlaho, Martina</creatorcontrib><creatorcontrib>Tomic, Vajdana</creatorcontrib><creatorcontrib>Vukojevic, Katarina</creatorcontrib><creatorcontrib>Vasilj, Anja</creatorcontrib><creatorcontrib>Pejic, Renato</creatorcontrib><creatorcontrib>Lesko, Josip</creatorcontrib><creatorcontrib>Soljic, Violeta</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of reproductive immunology (1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Orlovic Vlaho, Martina</au><au>Tomic, Vajdana</au><au>Vukojevic, Katarina</au><au>Vasilj, Anja</au><au>Pejic, Renato</au><au>Lesko, Josip</au><au>Soljic, Violeta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD25+FOXP3+ and CD4+CD25+ cells distribution in decidual departments of women with severe and mild pre‐eclampsia: Comparison with healthy pregnancies</atitle><jtitle>American journal of reproductive immunology (1989)</jtitle><date>2020-09</date><risdate>2020</risdate><volume>84</volume><issue>3</issue><spage>e13281</spage><epage>n/a</epage><pages>e13281-n/a</pages><issn>1046-7408</issn><eissn>1600-0897</eissn><abstract>Problem
The aim of this study was to quantify and compare the distribution of regulatory CD25+FOXP3+ and activated CD4+CD25+ T cells in decidua basalis and parietalis of severe and mild pre‐eclampsia (PE) to normal healthy pregnancies.
Method of study
Decidual tissue (decidua basalis and parietalis) of 13 women with mild PE, 15 women with severe PE, and 19 women with healthy term pregnancies were analyzed by immunohistochemistry and double immunofluorescence.
Results
The total number of CD25+FOXP3+ cells/mm2 in decidua basalis was decreased in the severe and mild PE versus normal pregnancy group. The total number of CD4+CD25+ cells/mm2 in decidua basalis was decreased in the severe PE versus normal pregnancy group. The number of CD25+FOXP3+ and CD4+CD25+ cells in decidua parietalis was decreased in both PE groups.
Conclusion
Our data suggest that immunological changes of PE reflect on decidua basalis and parietalis and emphasize the importance of characterizing T cells in both decidual departments.</abstract><cop>New Haven</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/aji.13281</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5337-0780</orcidid></addata></record> |
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| identifier | ISSN: 1046-7408 |
| ispartof | American journal of reproductive immunology (1989), 2020-09, Vol.84 (3), p.e13281-n/a |
| issn | 1046-7408 1600-0897 |
| language | eng |
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| source | Wiley Journals |
| subjects | CD25 antigen CD4 antigen Decidua Eclampsia forkhead transcription factors Foxp3 protein Immunofluorescence Immunohistochemistry Lymphocytes T Preeclampsia Pregnancy pre‐eclampsia regulatory T‐lymphocytes |
| title | CD25+FOXP3+ and CD4+CD25+ cells distribution in decidual departments of women with severe and mild pre‐eclampsia: Comparison with healthy pregnancies |
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