Zinc Interactions with a Soluble Mutated Rat Amylin to Mimic Whole Human Amylin: An Experimental and Simulation Approach to Understand Stoichiometry, Speciation and Coordination of the Metal Complexes

Islet amyloid polypeptide (IAPP) is a hormone co‐secreted with insulin and zinc from pancreatic β‐cells. To overcome the low solubility of human IAPP, we characterized zinc complexes species formed with 1) a mutated form of rat‐IAPP(1–37; R18 H) able to mimic the human IAPP, 2) the r‐IAPP(1–37) and...

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Veröffentlicht in:	Chemistry : a European journal 2020-10, Vol.26 (57), p.13072-13084
Hauptverfasser:	Magrì, Antonio, Tabbì, Giovanni, Di Natale, Giuseppe, La Mendola, Diego, Pietropaolo, Adriana, Zoroddu, Maria Antonietta, Peana, Massimiliano, Rizzarelli, Enrico
Format:	Artikel
Sprache:	eng
Schlagworte:	Amylin Amyloid Animals Chemistry Computer Simulation Conformation Coordination Complexes Coordination compounds DFT Electrical measurement Free energy Humans Insulin Islet Amyloid Polypeptide Metal complexes NMR NMR spectroscopy noncovalent interactions Nuclear magnetic resonance Pancreas Polypeptides Potentiometric analysis potentiometry Rats Speciation Stoichiometry Zinc Zinc - chemistry Zinc compounds
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