Reactions of cisplatin and cis-[PtI2(NH3)2] with molecular models of relevant protein sidechains: A comparative analysis

Quite surprisingly, cisplatin and cis-[PtI2(NH3)2] were found to manifest significant differences in their reactions with the model protein lysozyme. We decided to explore whether these differences recur when reacting these two Pt compounds with other proteins. Notably, ESI-MS measurements carried o...

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Veröffentlicht in:	Journal of inorganic biochemistry 2020-08, Vol.209, p.111096-111096, Article 111096
Hauptverfasser:	Tolbatov, Iogann, Marzo, Tiziano, Cirri, Damiano, Gabbiani, Chiara, Coletti, Cecilia, Marrone, Alessandro, Paciotti, Roberto, Messori, Luigi, Re, Nazzareno
Format:	Artikel
Sprache:	eng
Schlagworte:	Cis-diiodo-diamino‑platinum Cisplatin DFT ESI-MS Ligand substitution Protein sidechain Trans effect
Online-Zugang:	Volltext
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