Flagellar nanorobot with kinetic behavior investigation and 3D motion
Wirelessly controlled nanorobots have the potential to perform highly precise maneuvers within complex in vitro and in vivo environments. Flagellar nanorobots will be useful in a variety of biomedical applications, however, to date there has been little effort to investigate essential kinetic behavi...
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| Veröffentlicht in: | Nanoscale 2020-06, Vol.12 (22), p.12154-12164 |
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| creator | Tang, Jiannan Rogowski, Louis William Zhang, Xiao Kim, Min Jun |
| description | Wirelessly controlled nanorobots have the potential to perform highly precise maneuvers within complex
in vitro
and
in vivo
environments. Flagellar nanorobots will be useful in a variety of biomedical applications, however, to date there has been little effort to investigate essential kinetic behavior changes related to the geometric properties of the nanorobot and effects imparted to it by nearby boundaries. Flagellar nanorobots are composed of an avidin-coated magnetic nanoparticle head (MH) and a single biotin-tipped repolymerized flagellum that are driven by a wirelessly generated rotating magnetic field. Nanorobots with different MHs and flagellar lengths were manually guided to perform complex swimming trajectories under both bright-field and fluorescence microscopy visualizations. The experimental results show that rotational frequency, handedness of rotation direction, MH size, flagellar length, and distance to the bottom boundary significantly affect the kinematics of the nanorobot. The results reported herein summarize fundamental research that will be used for the design specifications necessary for optimizing the application of helical nanorobotic devices for use in delivery of therapeutic and imaging agents. Additionally, robotic nanoswimmers were successfully navigated and tracked in 3D using quantitative defocusing, which will significantly improve the efficiency, function, and application of the flagellar nanorobot.
Wirelessly controlled nanorobots have the potential to perform highly precise maneuvers within complex
in vitro
and
in vivo
environments. |
| doi_str_mv | 10.1039/d0nr02496a |
| format | Article |
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in vitro
and
in vivo
environments. Flagellar nanorobots will be useful in a variety of biomedical applications, however, to date there has been little effort to investigate essential kinetic behavior changes related to the geometric properties of the nanorobot and effects imparted to it by nearby boundaries. Flagellar nanorobots are composed of an avidin-coated magnetic nanoparticle head (MH) and a single biotin-tipped repolymerized flagellum that are driven by a wirelessly generated rotating magnetic field. Nanorobots with different MHs and flagellar lengths were manually guided to perform complex swimming trajectories under both bright-field and fluorescence microscopy visualizations. The experimental results show that rotational frequency, handedness of rotation direction, MH size, flagellar length, and distance to the bottom boundary significantly affect the kinematics of the nanorobot. The results reported herein summarize fundamental research that will be used for the design specifications necessary for optimizing the application of helical nanorobotic devices for use in delivery of therapeutic and imaging agents. Additionally, robotic nanoswimmers were successfully navigated and tracked in 3D using quantitative defocusing, which will significantly improve the efficiency, function, and application of the flagellar nanorobot.
Wirelessly controlled nanorobots have the potential to perform highly precise maneuvers within complex
in vitro
and
in vivo
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in vitro
and
in vivo
environments. Flagellar nanorobots will be useful in a variety of biomedical applications, however, to date there has been little effort to investigate essential kinetic behavior changes related to the geometric properties of the nanorobot and effects imparted to it by nearby boundaries. Flagellar nanorobots are composed of an avidin-coated magnetic nanoparticle head (MH) and a single biotin-tipped repolymerized flagellum that are driven by a wirelessly generated rotating magnetic field. Nanorobots with different MHs and flagellar lengths were manually guided to perform complex swimming trajectories under both bright-field and fluorescence microscopy visualizations. The experimental results show that rotational frequency, handedness of rotation direction, MH size, flagellar length, and distance to the bottom boundary significantly affect the kinematics of the nanorobot. The results reported herein summarize fundamental research that will be used for the design specifications necessary for optimizing the application of helical nanorobotic devices for use in delivery of therapeutic and imaging agents. Additionally, robotic nanoswimmers were successfully navigated and tracked in 3D using quantitative defocusing, which will significantly improve the efficiency, function, and application of the flagellar nanorobot.
Wirelessly controlled nanorobots have the potential to perform highly precise maneuvers within complex
in vitro
and
in vivo
environments.</description><subject>Biomechanical Phenomena</subject><subject>Biomedical materials</subject><subject>Biotin</subject><subject>Chemical compounds</subject><subject>Defocusing</subject><subject>Design optimization</subject><subject>Design specifications</subject><subject>Flagella</subject><subject>Fluorescence</subject><subject>Kinematics</subject><subject>Kinetics</subject><subject>Maneuvers</subject><subject>Nanoparticles</subject><subject>Pharmacology</subject><subject>Reagents</subject><subject>Robotics</subject><subject>Rotation</subject><subject>Swimming</subject><subject>Three dimensional motion</subject><issn>2040-3364</issn><issn>2040-3372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90U1LAzEQBuAgitbqxbuy4kWE6iSZ_chRbKtCURA9L2k2W1PbpCbbiv_e1NYKHjzl62FmeEPIEYVLClxcVWA9MBSZ3CItBggdznO2vdlnuEf2QxgDZIJnfJfs8agBc9oivf5EjvRkIn1ipXXeDV2TfJjmNXkzVjdGJUP9KhfG-cTYhQ6NGcnGOJtIWyW8m0zd8nRAdmo5CfpwvbbJS7_3fHPXGTze3t9cDzoq9m06mUDBAUWKnGqmUo4pskoryDiDeJWKrAANTPC8RoUFpjXjNWKRFxVQlfM2OV_VnXn3Po_TlFMT1HJ8q908lAxBUMEywSI9-0PHbu5tnC4qSrHgSEVUFyulvAvB67qceTOV_rOkUC7DLbvw8PQd7nXEJ-uS8-FUVxv6k2YEpyvgg9q8_v5OOavqaI7_M_wLkPSGjQ</recordid><startdate>20200611</startdate><enddate>20200611</enddate><creator>Tang, Jiannan</creator><creator>Rogowski, Louis William</creator><creator>Zhang, Xiao</creator><creator>Kim, Min Jun</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0819-1644</orcidid><orcidid>https://orcid.org/0000-0001-6640-6407</orcidid><orcidid>https://orcid.org/0000-0002-0444-6937</orcidid><orcidid>https://orcid.org/0000-0002-7623-5573</orcidid></search><sort><creationdate>20200611</creationdate><title>Flagellar nanorobot with kinetic behavior investigation and 3D motion</title><author>Tang, Jiannan ; Rogowski, Louis William ; Zhang, Xiao ; Kim, Min Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-694930495431e2c534542dec0632031e59680e02937f4c4845f23f44878d01c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biomechanical Phenomena</topic><topic>Biomedical materials</topic><topic>Biotin</topic><topic>Chemical compounds</topic><topic>Defocusing</topic><topic>Design optimization</topic><topic>Design specifications</topic><topic>Flagella</topic><topic>Fluorescence</topic><topic>Kinematics</topic><topic>Kinetics</topic><topic>Maneuvers</topic><topic>Nanoparticles</topic><topic>Pharmacology</topic><topic>Reagents</topic><topic>Robotics</topic><topic>Rotation</topic><topic>Swimming</topic><topic>Three dimensional motion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tang, Jiannan</creatorcontrib><creatorcontrib>Rogowski, Louis William</creatorcontrib><creatorcontrib>Zhang, Xiao</creatorcontrib><creatorcontrib>Kim, Min Jun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Nanoscale</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, Jiannan</au><au>Rogowski, Louis William</au><au>Zhang, Xiao</au><au>Kim, Min Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Flagellar nanorobot with kinetic behavior investigation and 3D motion</atitle><jtitle>Nanoscale</jtitle><addtitle>Nanoscale</addtitle><date>2020-06-11</date><risdate>2020</risdate><volume>12</volume><issue>22</issue><spage>12154</spage><epage>12164</epage><pages>12154-12164</pages><issn>2040-3364</issn><eissn>2040-3372</eissn><abstract>Wirelessly controlled nanorobots have the potential to perform highly precise maneuvers within complex
in vitro
and
in vivo
environments. Flagellar nanorobots will be useful in a variety of biomedical applications, however, to date there has been little effort to investigate essential kinetic behavior changes related to the geometric properties of the nanorobot and effects imparted to it by nearby boundaries. Flagellar nanorobots are composed of an avidin-coated magnetic nanoparticle head (MH) and a single biotin-tipped repolymerized flagellum that are driven by a wirelessly generated rotating magnetic field. Nanorobots with different MHs and flagellar lengths were manually guided to perform complex swimming trajectories under both bright-field and fluorescence microscopy visualizations. The experimental results show that rotational frequency, handedness of rotation direction, MH size, flagellar length, and distance to the bottom boundary significantly affect the kinematics of the nanorobot. The results reported herein summarize fundamental research that will be used for the design specifications necessary for optimizing the application of helical nanorobotic devices for use in delivery of therapeutic and imaging agents. Additionally, robotic nanoswimmers were successfully navigated and tracked in 3D using quantitative defocusing, which will significantly improve the efficiency, function, and application of the flagellar nanorobot.
Wirelessly controlled nanorobots have the potential to perform highly precise maneuvers within complex
in vitro
and
in vivo
environments.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>32490471</pmid><doi>10.1039/d0nr02496a</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-0819-1644</orcidid><orcidid>https://orcid.org/0000-0001-6640-6407</orcidid><orcidid>https://orcid.org/0000-0002-0444-6937</orcidid><orcidid>https://orcid.org/0000-0002-7623-5573</orcidid></addata></record> |
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| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Biomechanical Phenomena Biomedical materials Biotin Chemical compounds Defocusing Design optimization Design specifications Flagella Fluorescence Kinematics Kinetics Maneuvers Nanoparticles Pharmacology Reagents Robotics Rotation Swimming Three dimensional motion |
| title | Flagellar nanorobot with kinetic behavior investigation and 3D motion |
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