Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells

Non-specific inhibition of Rho-associated kinases (ROCKs) alleviated renal fibrosis in the unilateral ureteral obstruction (UUO) model, while genetic deletion of ROCK1 did not affect renal pathology in mice. Thus, whether ROCK2 plays a role in renal tubulointerstitial fibrosis needs to be clarified....

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Clinical science (1979) 2020-06, Vol.134 (12), p.1357-1376
Hauptverfasser:	You, Ran, Zhou, Wei, Li, Yanwei, Zhang, Yue, Huang, Songming, Jia, Zhanjun, Zhang, Aihua
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!