Clinical implications of thoracic duct dilatation in patients with chronic liver disease
This study aimed to investigate the association between the degree of thoracic duct dilatation and the progression of chronic liver disease.In this cross-sectional and retrospective study, 179 patients (mean age, 60.9 years; 114 men) with chronic liver disease who underwent chest CT were enrolled. D...
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| Veröffentlicht in: | Medicine (Baltimore) 2020-05, Vol.99 (22), p.e19889-e19889 |
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| creator | Park, Seung Woon Kim, Tae Hyung Ham, Soo-Youn Um, Soon Ho Goh, Hyun Gil Lee, SunHye Lee, Han Ah Yim, Sun Young Seo, Yeon Seok Yim, Hyung Joon An, Hyunggin Oh, Yu-Whan |
| description | This study aimed to investigate the association between the degree of thoracic duct dilatation and the progression of chronic liver disease.In this cross-sectional and retrospective study, 179 patients (mean age, 60.9 years; 114 men) with chronic liver disease who underwent chest CT were enrolled. Dilatation of the left distal thoracic ducts (DTD) was measured and divided into the following 3 grades according to the maximum transverse diameter: grade 0, invisible thoracic duct; grade 1, visible duct with |
| doi_str_mv | 10.1097/MD.0000000000019889 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2408844420</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2408844420</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3508-bd6e2bc9da14c7b7dbbc04a858e53d0305a77c54643e5197b172e765a900e7aa3</originalsourceid><addsrcrecordid>eNpdkE1PGzEQhq2qqAm0vwCp8rGXBX-u7WOV8CUl4gISt5XXO9GaOrup7SXi32MILRJzmVczz7wjvQidUnJGiVHn6-UZ-ShqtDZf0JxKXlfS1OIrmhPCZKWMEjN0nNJjgbhi4huacSY05TWfo4dF8IN3NmC_3YUish-HhMcNzv0YrfMOd5PLuPPB5rcl9gPeFQVDTnjvc49dH8figYN_gljIBDbBd3S0sSHBj_d-gu4vL-4W19Xq9upm8XtVOS6JrtquBtY601kqnGpV17aOCKulBsk7wom0SjkpasFBUqNaqhioWlpDCChr-Qn6dfDdxfHvBCk3W58chGAHGKfUMEG0FkIwUlB-QF0cU4qwaXbRb218bihpXiNt1svmc6Tl6uf7g6ndQvf_5l-GBRAHYD-GDDH9CdMeYtODDbl_85PKsIoRVhQzpHodaf4Ce0mBYw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2408844420</pqid></control><display><type>article</type><title>Clinical implications of thoracic duct dilatation in patients with chronic liver disease</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Wolters Kluwer Open Health</source><source>IngentaConnect Free/Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Park, Seung Woon ; Kim, Tae Hyung ; Ham, Soo-Youn ; Um, Soon Ho ; Goh, Hyun Gil ; Lee, SunHye ; Lee, Han Ah ; Yim, Sun Young ; Seo, Yeon Seok ; Yim, Hyung Joon ; An, Hyunggin ; Oh, Yu-Whan</creator><creatorcontrib>Park, Seung Woon ; Kim, Tae Hyung ; Ham, Soo-Youn ; Um, Soon Ho ; Goh, Hyun Gil ; Lee, SunHye ; Lee, Han Ah ; Yim, Sun Young ; Seo, Yeon Seok ; Yim, Hyung Joon ; An, Hyunggin ; Oh, Yu-Whan</creatorcontrib><description>This study aimed to investigate the association between the degree of thoracic duct dilatation and the progression of chronic liver disease.In this cross-sectional and retrospective study, 179 patients (mean age, 60.9 years; 114 men) with chronic liver disease who underwent chest CT were enrolled. Dilatation of the left distal thoracic ducts (DTD) was measured and divided into the following 3 grades according to the maximum transverse diameter: grade 0, invisible thoracic duct; grade 1, visible duct with <5-mm diameter; grade 2, diameter of ≥5 mm. Statistical analyses were conducted using the binary logistic regression model.The proportion of grade 2 DTD was notably higher as the chronic liver disease progressed to cirrhosis. Visible DTD on chest CT was significantly related to the presence of cirrhosis (odds ratio [OR], 3.809; P = .027) and significant varix (OR, 3.211; P = .025). Grade 2 DTD was observed more frequently in patients with ascites (OR, 2.788; P = .039). However, 40% of patients with cirrhosis and ascites still exhibited no visible DTD while demonstrating significant amount of ascites, and their ascites were more predominant of recent onset and transient than that observed in other patients (85.7% vs 48.4%, P = .010 and 66.7% vs 29.0%, P = .009, respectively).The degree of thoracic duct dilatation is significantly associated with progression to cirrhosis and advancement of portal hypertension. Further, insufficient lymph drainage to DTD might contribute to the development of ascites.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000019889</identifier><identifier>PMID: 32481363</identifier><language>eng</language><publisher>United States: the Author(s). Published by Wolters Kluwer Health, Inc</publisher><subject>Aged ; Ascites - etiology ; Ascites - pathology ; Chronic Disease ; Dilatation, Pathologic ; Disease Progression ; Female ; Humans ; Liver Cirrhosis - complications ; Liver Cirrhosis - pathology ; Male ; Middle Aged ; Retrospective Studies ; Thoracic Duct - pathology</subject><ispartof>Medicine (Baltimore), 2020-05, Vol.99 (22), p.e19889-e19889</ispartof><rights>the Author(s). Published by Wolters Kluwer Health, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3508-bd6e2bc9da14c7b7dbbc04a858e53d0305a77c54643e5197b172e765a900e7aa3</citedby><cites>FETCH-LOGICAL-c3508-bd6e2bc9da14c7b7dbbc04a858e53d0305a77c54643e5197b172e765a900e7aa3</cites><orcidid>0000-0002-7747-4293</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32481363$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Seung Woon</creatorcontrib><creatorcontrib>Kim, Tae Hyung</creatorcontrib><creatorcontrib>Ham, Soo-Youn</creatorcontrib><creatorcontrib>Um, Soon Ho</creatorcontrib><creatorcontrib>Goh, Hyun Gil</creatorcontrib><creatorcontrib>Lee, SunHye</creatorcontrib><creatorcontrib>Lee, Han Ah</creatorcontrib><creatorcontrib>Yim, Sun Young</creatorcontrib><creatorcontrib>Seo, Yeon Seok</creatorcontrib><creatorcontrib>Yim, Hyung Joon</creatorcontrib><creatorcontrib>An, Hyunggin</creatorcontrib><creatorcontrib>Oh, Yu-Whan</creatorcontrib><title>Clinical implications of thoracic duct dilatation in patients with chronic liver disease</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>This study aimed to investigate the association between the degree of thoracic duct dilatation and the progression of chronic liver disease.In this cross-sectional and retrospective study, 179 patients (mean age, 60.9 years; 114 men) with chronic liver disease who underwent chest CT were enrolled. Dilatation of the left distal thoracic ducts (DTD) was measured and divided into the following 3 grades according to the maximum transverse diameter: grade 0, invisible thoracic duct; grade 1, visible duct with <5-mm diameter; grade 2, diameter of ≥5 mm. Statistical analyses were conducted using the binary logistic regression model.The proportion of grade 2 DTD was notably higher as the chronic liver disease progressed to cirrhosis. Visible DTD on chest CT was significantly related to the presence of cirrhosis (odds ratio [OR], 3.809; P = .027) and significant varix (OR, 3.211; P = .025). Grade 2 DTD was observed more frequently in patients with ascites (OR, 2.788; P = .039). However, 40% of patients with cirrhosis and ascites still exhibited no visible DTD while demonstrating significant amount of ascites, and their ascites were more predominant of recent onset and transient than that observed in other patients (85.7% vs 48.4%, P = .010 and 66.7% vs 29.0%, P = .009, respectively).The degree of thoracic duct dilatation is significantly associated with progression to cirrhosis and advancement of portal hypertension. Further, insufficient lymph drainage to DTD might contribute to the development of ascites.</description><subject>Aged</subject><subject>Ascites - etiology</subject><subject>Ascites - pathology</subject><subject>Chronic Disease</subject><subject>Dilatation, Pathologic</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Liver Cirrhosis - complications</subject><subject>Liver Cirrhosis - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Thoracic Duct - pathology</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE1PGzEQhq2qqAm0vwCp8rGXBX-u7WOV8CUl4gISt5XXO9GaOrup7SXi32MILRJzmVczz7wjvQidUnJGiVHn6-UZ-ShqtDZf0JxKXlfS1OIrmhPCZKWMEjN0nNJjgbhi4huacSY05TWfo4dF8IN3NmC_3YUish-HhMcNzv0YrfMOd5PLuPPB5rcl9gPeFQVDTnjvc49dH8figYN_gljIBDbBd3S0sSHBj_d-gu4vL-4W19Xq9upm8XtVOS6JrtquBtY601kqnGpV17aOCKulBsk7wom0SjkpasFBUqNaqhioWlpDCChr-Qn6dfDdxfHvBCk3W58chGAHGKfUMEG0FkIwUlB-QF0cU4qwaXbRb218bihpXiNt1svmc6Tl6uf7g6ndQvf_5l-GBRAHYD-GDDH9CdMeYtODDbl_85PKsIoRVhQzpHodaf4Ce0mBYw</recordid><startdate>20200529</startdate><enddate>20200529</enddate><creator>Park, Seung Woon</creator><creator>Kim, Tae Hyung</creator><creator>Ham, Soo-Youn</creator><creator>Um, Soon Ho</creator><creator>Goh, Hyun Gil</creator><creator>Lee, SunHye</creator><creator>Lee, Han Ah</creator><creator>Yim, Sun Young</creator><creator>Seo, Yeon Seok</creator><creator>Yim, Hyung Joon</creator><creator>An, Hyunggin</creator><creator>Oh, Yu-Whan</creator><general>the Author(s). Published by Wolters Kluwer Health, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7747-4293</orcidid></search><sort><creationdate>20200529</creationdate><title>Clinical implications of thoracic duct dilatation in patients with chronic liver disease</title><author>Park, Seung Woon ; Kim, Tae Hyung ; Ham, Soo-Youn ; Um, Soon Ho ; Goh, Hyun Gil ; Lee, SunHye ; Lee, Han Ah ; Yim, Sun Young ; Seo, Yeon Seok ; Yim, Hyung Joon ; An, Hyunggin ; Oh, Yu-Whan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3508-bd6e2bc9da14c7b7dbbc04a858e53d0305a77c54643e5197b172e765a900e7aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Ascites - etiology</topic><topic>Ascites - pathology</topic><topic>Chronic Disease</topic><topic>Dilatation, Pathologic</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Liver Cirrhosis - complications</topic><topic>Liver Cirrhosis - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Thoracic Duct - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Seung Woon</creatorcontrib><creatorcontrib>Kim, Tae Hyung</creatorcontrib><creatorcontrib>Ham, Soo-Youn</creatorcontrib><creatorcontrib>Um, Soon Ho</creatorcontrib><creatorcontrib>Goh, Hyun Gil</creatorcontrib><creatorcontrib>Lee, SunHye</creatorcontrib><creatorcontrib>Lee, Han Ah</creatorcontrib><creatorcontrib>Yim, Sun Young</creatorcontrib><creatorcontrib>Seo, Yeon Seok</creatorcontrib><creatorcontrib>Yim, Hyung Joon</creatorcontrib><creatorcontrib>An, Hyunggin</creatorcontrib><creatorcontrib>Oh, Yu-Whan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Seung Woon</au><au>Kim, Tae Hyung</au><au>Ham, Soo-Youn</au><au>Um, Soon Ho</au><au>Goh, Hyun Gil</au><au>Lee, SunHye</au><au>Lee, Han Ah</au><au>Yim, Sun Young</au><au>Seo, Yeon Seok</au><au>Yim, Hyung Joon</au><au>An, Hyunggin</au><au>Oh, Yu-Whan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical implications of thoracic duct dilatation in patients with chronic liver disease</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2020-05-29</date><risdate>2020</risdate><volume>99</volume><issue>22</issue><spage>e19889</spage><epage>e19889</epage><pages>e19889-e19889</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>This study aimed to investigate the association between the degree of thoracic duct dilatation and the progression of chronic liver disease.In this cross-sectional and retrospective study, 179 patients (mean age, 60.9 years; 114 men) with chronic liver disease who underwent chest CT were enrolled. Dilatation of the left distal thoracic ducts (DTD) was measured and divided into the following 3 grades according to the maximum transverse diameter: grade 0, invisible thoracic duct; grade 1, visible duct with <5-mm diameter; grade 2, diameter of ≥5 mm. Statistical analyses were conducted using the binary logistic regression model.The proportion of grade 2 DTD was notably higher as the chronic liver disease progressed to cirrhosis. Visible DTD on chest CT was significantly related to the presence of cirrhosis (odds ratio [OR], 3.809; P = .027) and significant varix (OR, 3.211; P = .025). Grade 2 DTD was observed more frequently in patients with ascites (OR, 2.788; P = .039). However, 40% of patients with cirrhosis and ascites still exhibited no visible DTD while demonstrating significant amount of ascites, and their ascites were more predominant of recent onset and transient than that observed in other patients (85.7% vs 48.4%, P = .010 and 66.7% vs 29.0%, P = .009, respectively).The degree of thoracic duct dilatation is significantly associated with progression to cirrhosis and advancement of portal hypertension. Further, insufficient lymph drainage to DTD might contribute to the development of ascites.</abstract><cop>United States</cop><pub>the Author(s). Published by Wolters Kluwer Health, Inc</pub><pmid>32481363</pmid><doi>10.1097/MD.0000000000019889</doi><orcidid>https://orcid.org/0000-0002-7747-4293</orcidid></addata></record> |
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| subjects | Aged Ascites - etiology Ascites - pathology Chronic Disease Dilatation, Pathologic Disease Progression Female Humans Liver Cirrhosis - complications Liver Cirrhosis - pathology Male Middle Aged Retrospective Studies Thoracic Duct - pathology |
| title | Clinical implications of thoracic duct dilatation in patients with chronic liver disease |
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